Transcript Office of Research Infrastructure Programs

Funding Opportunities for
Biomedical Research Support
May 6, 2015
Franziska B. Grieder, DVM, PhD
Director, Office of Research Infrastructure Programs (ORIP)
National Institutes of Health
Bethesda, Maryland
Securing Research Funding
• Why?
• When?
• With whom?
• From where?
• NIH
• Other Federal organizations
• Private and local groups
• How?
Securing Research Funding
• Why?
• When?
• With whom?
• From where?
• NIH
• Other Federal organizations
• Private and local groups
• How? …oh yes, if we all could answer this one!
Securing Research Funding
• Why?
• When?
• With whom?
• From where?
• NIH
• Other Federal organizations
• Private and local groups
• How? …oh yes, if we all could answer this one!
Wait for the second talk for some tips and advice.
NIH – An Overview and Introduction
“Science in pursuit of fundamental knowledge about
the nature and behavior of living systems and the
application of that knowledge to enhance health,
lengthen life, and reduce illness and disability.”
What is the NIH?
OD
NCI
NEI
NHLBI
NHGRI
NIA
NIAAA
NIAID
NIAMS
NIBIB
NICHD
NIDCD
NIDCR
NIDDK
NIDA
NIEHS
NIGMS
NIMH
NINDS
NINR
NLM
CIT
CSR
FIC
NCCIH
NIMHD
NCATS
CC
27 Institutes and Centers
NIH – Understanding its dual nature
NIH INTRAMURAL RESEARCH
NIH EXTRAMURAL RESEARCH
NIH is an institution
Alaska
5
Data: Assoc of University Technology Managers (AUTM) Survey 2004
Supports >6,000 scientists
(~10% of NIH budget)
• Primary location Bethesda, MD
• A few labs throughout US
Supports >3,000 institutions worldwide;
>300,000 scientists & research personnel
(~83% of NIH budget)
• Awards issued to >100 countries
• Clinical, Basic, & Translational Research
http://grants.nih.gov
8
NIH – Information you should know
http://report.nih.gov/index.aspx
Securing Research Funding
• What do you need to know?
•
•
•
•
•
Different NIH Institutes and Centers
Different NIH Offices and Programs
Different Funding Mechanisms
Different Deadlines
New and evolving Guidelines (e.g., biosketches)
• Where can you get advice?
http://grants.nih.gov
11
Office of Research Infrastructure
Programs (ORIP)
• ORIP is not an NIH
Institute/Center
• Several programs formerly
housed in NCRR were
reassigned to the new office
within the OD
• Infrastructure can be physical,
intellectual, and human
• ORIP’s mission is to provide
resources to drive research
discoveries
• Research infrastructure
programs
• Research-related resource
programs
• NIH’s science education efforts
Division of Program Coordination, Planning,
and Strategic Initiatives (DPCPSI)
Office of Portfolio Analysis
George Santangelo, Ph.D.
Immediate Office of
the DPCPSI Director
James M. Anderson, M.D., Ph.D.
Office of
AIDS
Research
Jack Whitescarver,
Ph.D.
Office of
Research on
Women’s
Health
Janine Clayton,
M.D.
Office of
Behavioral
and Social
Sciences
Research
Bill Riley, Ph.D.
(Acting)
DPCPSI's mission includes identifying
emerging scientific opportunities,
rising public health challenges, and
scientific knowledge gaps that merit
further research
Office of
Disease
Prevention
David Murray,
Ph.D.
Office of Dietary
Supplements
Paul M. Coates, Ph.D.
Office of Program Evaluation and
Performance
Rosanna Ng, M.A.
Office of Administrative Management
and Communications
Ruby Akomeah
Office of
Strategic
Coordination
Betsy Wilder, Ph.D.
Office of
Research
Infrastructure
Programs
Franziska Grieder,
D.V.M., Ph.D.
Division of
Comparative
Medicine
Division of
Construction and
Instruments
Office of Science
Education
ORIP FY2014 Budget & Portfolio
ORIP FY2014 Grant Budget & Portfolio
2 Mechanisms
67 grants
SBIR/STTR
3%
4 Mechanisms
19 grants
SEPA
6%
2 Mechanisms
124 grants
13 Mechanisms
229 grants
DCI
27%
DCM
64%
Active grants (total): 644 (incl RR)
*Long-term construction
oversight: 457 (including ARRA)
Total of over 20 mechanisms
http://dpcpsi.nih.gov/orip
Division of Comparative Medicine (DCM)
• Develop, characterize, preserve, and improve
mammalian and non-mammalian models of human
disease
• Develop new initiatives on specific animal-based topics
• Develop the workforce that supports and contributes to
animal-based research and resources
R21: Exploratory/Developmental Grant
• Intended to encourage exploratory/developmental
research by providing support for the early and
conceptual stages of project development
• Request a project period of up to two years
• Budget for direct costs may not exceed $275,000, with
no more than $200,000 requested in any single year
• Cannot be renewed
• No preliminary required – may be included if available
• Research Strategy may not exceed 6 page
R21 – ORIP Considerations
• ORIP does not accept unsolicited R21 applications
• But other NIH Institutes and Centers do
• PA-13-145 Development of Animal Models and Related Biological
Materials for Research (R21)
• Develop, characterize or improve animal models for human
disease
• Improve diagnosis and control of diseases that might interfere
with animal use for biomedical research purposes
• Models to be considered must be applicable to the research
interests of > 2 categorical NIH Institutes/Centers
• Excluded are studies that modify specific genes or levels of gene
expression in animals with the purpose of understanding the
effect of the gene on phenotypes which are not directly related to
human diseases
R21 Topics of Interest
• Disease models
• Genetically-modified
animals and preservation of
important disease models
• Fundamental biology of
animal model systems
• Disease biomarkers
• Genetically encoded
reporters
• Biological molecule
interactive and functional
networks
• Animal models for human
rare disease conditions
• Complementary
approaches to use of
animal models
• Animal diseases affecting
colony health
Small Business Programs
• Small Business Innovation Research
(SBIR) Program
• Funds early stage small businesses
that are seeking to commercialize
innovative biomedical technologies
• Helps small businesses participate in
federal research and development
• PI’s primary employment must be
with the small business
• Small Business Technology Transfer
(STTR) Program
• Similar to SBIR program, but
requires that a small business
formally collaborate with a research
institution
• Primary employment is not
stipulated
SBIR/STTR
Small Business (SBIR and STTR)
Program Announcements
• PAR-15-186: Novel Tools and Devices for Animal Research Facilities and to Support the Care of Animal
Models (R43/R44)
• PAR-15-185: Development of Novel Tools and Devices to Support the Care of Animal Models and
Animal Care Research Facilities (R41/R42)
• PA-15-086: Development of Novel and Emerging Technologies to Support Zebrafish Models for
Biomedical Research (SBIR [R43/R44])
• PA-15-087: Development of Novel and Emerging Technologies to Support Zebrafish Models for
Biomedical Research (STTR [R41/R42])
• PA-15-052: Lab to Marketplace: Tools for Biomedical and Behavioral Research (SBIR [R43/R44])
• PAR-14-088: Direct Phase II SBIR Grants to Support Biomedical Technology Development (R43/R44)
• PA-14-072: PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant
Applications (STTR)(R41/R42)
• PA-14-071: PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business
Innovation Research Grant Applications (SBIR)(R43/R44)
SBIR/STTR Topics of Interest
• Novel tools and equipment to improve care and facilitate
monitoring of healthy animals
• Vaccines and new therapeutic agents for prevention and
control of selected laboratory animal diseases (i.e. herpes
virus B in NHPs)
• Green technologies to benefit welfare of research animals
• Reagents for lower organisms (i.e. zebrafish)
• Technologies to rapidly phenotype large numbers of animals
• Technologies for cryopreservation and long-term
maintenance of laboratory animal embryos and gametes
• Animal cell culture techniques and computational methods
to reduce number of animals used in studies
http://dpcpsi.nih.gov/orip
DCM-Supported Grants and Activities
• Research Program Grants
• Investigator-initiated Hypothesis-driven awards
• SBIR/STTR
• Center Grants
• Grants
• Animal and Biological Materials Resources
• Cooperative Agreements
• Animal and Biological Materials Resources
• Training programs
• Institutional and individual awards
• Conference/Meeting/Supplements
ORIP – DCM programs
• Disease model resources
• High-quality, disease-free animals, specialized animal research
facilities, and biological materials (e.g., antibody, snake venom)
• Rodents, Fish, Non-human Primates, others (e.g., Pigs, Flies, Worm,
Tissues and Cells)
• Resource Centers with the infrastructure that support
investigators’ needs
• Caging or tanks
• Technology
• Collaboration
DVM-Specific Training Opportunities For
Research Institutions
• National Research Service Awards (NRSAs)
• T35 – Professional student short-term summer research
training
• T32 (pre-DVM) – One year hypothesis-based, animaloriented research training for veterinary students
• T32 (post-DVM) – Three year post-DVM research training for
highly qualified veterinarians
• Number of Training Grants and Trainees for FY 2013
• T35 – 21 grants, 178 trainees (21 grants for FY 2014)
• T32 (pre-DVM) – 6 grants, 9 trainees (3 grants for FY 2014)
• T32 (post-DVM) – 19 grants, 75 trainees (18 grants for FY
2014)
DVM-Specific Training Opportunities For
Individuals
• National Research Service Awards (NRSAs)
• F30 – Individual predoctoral MD/PhD or other dual-doctoral
degree fellowship (Parent F30)
• F31 – Individual predoctoral fellowship (Parent F31)
• F31 – Predoctoral individual national research service award for
individual predoctoral fellowships to promote diversity in healthrelated research (Parent F31 – Diversity)
• Career Development Awards
• K01 – Mentored Research Scientist Development Award
• K99/R00 – NIH Pathway to Independence Award
• Number of Training Grants and Trainees in FY 2014
• F30/F31 – receiving applications for the first time in FY 2015
• K01 – 21 grants/trainees
• K99/R00 – no applications or grants in FY 2014, 1 application in FY 2015
http://dpcpsi.nih.gov/orip
ORIP – DCI programs
• ORIP can provide Shared Instrumentation Grant (SIG)
and High-End Instrumentation (HEI) Programs
•
•
•
•
•
SIG: PAR-15-088 (submission deadline was May 29, 2015)
Award size $50k - $600k
HEI: PAR-15-118 (submission deadline was May 29, 2015)
Award size $600k - $2M
Key points:
• Eligibility, Need, Enhancing NIH-funded research, Technical
expertise, Administration and institutional commitment
• One year funding appropriation. Annual receipt dates.
ORIP – DCI programs
Construction Awards
• Construction - limited to G20 – Animal Facility Improvement
Program PAR-14-251, Developing and Improving Institutional
Animal Resources (submission deadline was Aug 3, 201)
• Goals: Renovate, repair, or Improve individual animal resources
• Award size up to $500k
• Note: No current C06 construction program
http://dpcpsi.nih.gov/orip
Example – OSE/SEPA Programs
Office of Science Education/Science Education Partnership Award
• Educational Pre-K to grade 12 (P-12) resources to increase
the numbers of urban, rural and minority students
considering research and medical careers
• Partnerships between scientists or clinicians and educators,
community organizations or science museums.
•
•
Served/year - 82,500 Students,
5,700 Teachers, 2,100 Schools
(GAO audit data)
One Health: Integrating The Veterinarian Scientist
Into The Biomedical Research Enterprise
Workshop Details
Meeting Organizing Committee
• April 7-8, 2015
• Peter Ernst, DVM, PhD (University of
California, San Diego)
• James Fox, DVM (MIT)
• Michael Kent, PhD (Oregon State University)
• Deborah Kochevar, DVM, PhD (Tufts
University)
• Andrew Lackner, DVM, PhD (Tulane National
Primate Research Center)
• Ronald Sokol, MD (University of Colorado)
• Susan VandeWoude, DVM (Colorado State
University)
• NIH main campus, Bethesda, MD
• Objective: to bring together veterinarians,
clinicians and basic researchers to provide
information and advice on how basic and
applied biomedical research, utilizing the
concept of One Health, can advance the NIH
mission relative to human health and disease
• http://www.scgcorp.com/ORIPOneHealth2015
Session Topics
• Case studies from multidisciplinary teams
using both animal and human subjects
to study infectious diseases, cancer, and
neurological diseases, among others
• One Health panel perspectives from
various centers, federal agencies and
industry
• Panel discussions related to NIH training
programs that utilize the concept of One
Health, including ways to improve
training of multidisciplinary teams