Transcript AnoBase: Gene tool

AnoXcell in AnoBase
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2001 – 2010 Decade to Roll Back Malaria (WHO)
300 million acute cases - 1 million deaths / year
Africa: 500k children / 20% die / 7% PND
Vaccines (40% delay) /Insecticide treated net (ITNs)
Figure 1 Overview of Ensembl Gene Build
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RepeatMasker
GeneScan
tRNAscan
BLAST searches
AnoBase Gene tool
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Known status
Known symbol
Predicted genes
AnoXcel
Met @ position 1 - 20
AnoXcel sections
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MW and pI calculated
from individual values
for each aa
Frequency of each aa
in proteome.
BLAST vs NR
BLAST vs GO
BLAST vs SMART
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BLAST
BLAST
BLAST
BLAST
BLAST
BLAST
BLAST
vs
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vs
vs
vs
PFAM
COG
KOG
Drosophila
C. elegans
Human
Anopheles
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Clustering via blastp
Blastp vs the database
itself
Join criteria as described
per category
Gaps are calculated
before 2 proteins to be
joined in the same
cluster.
Things to be done
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Full incorporation of ENSEMBL’s genes
submitted by the community
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AnoEST
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Integration of the tool into Vectorbase