Transcript Breast Cancer web page

Uterine Cancer
• Endometrial (or uterine) cancer will account for 50,000 new cases and 8200 deaths
in the United States in 2013.
• Two genetic disorders are associated with abnormal genes – Lynch syndrome and
Cowden syndrome. Lynch syndrome accounts for 2% of all uterine cancers.
• In Lynch syndrome the risk of uterine cancer by age 70 is 50% (range 25% to 60%)
compared to 2.7% for the general population.
• Average age of onset is 48
• Like colon cancer patients with Lynch, women with Lynch and endometrial cancer
have a better prognosis.
• The second disorder is Cowden Syndrome.
• This is a mutation in the pTEN protein, which is one
of the proteins responsible for regulating cell
growth.
• Clinically, Cowden is not one finding but a
constellation of factors that increase the chance of
finding this altered gene.
• The following is the consensus criteria for the
diagnosis:
• To check for Cowden syndrome, you will be
assessed to see if you meet criteria for a research
study offered by the Cleveland Clinic.
• If you meet criteria, the Cleveland Clinic has a
grant to look for pTEN mutations.
• The test is also available through reference labs.
• Beyond these two syndromes there are other
conditions that can increase your chances for
uterine cancer.
• Call for an appointment so we can discuss your
family history and whether you might be a
carrier of one of these genes.