Transcript Academic and Research Plan presentation

Trust Board
April 2008
Research strategy for
RNOH-IOMS
David Marsh
Professor of Clinical Orthopaedics
Institute of Orthopaedics and Musculoskeletal Science,
University College London
Royal National Orthopaedic Hospital
Stanmore, UK
A joint IOMS-RNOH academic
strategy is an essential part of the
Outline Business Case
• One of three stipulations in the letter from the
SHA inviting submission:
“set out a clear commitment to support the work
of the university and its partners in achieving
AHSC status and strengthening the Orthopaedic
Institute”
Academic Health Science Centre
• Joint Academic Plan:
CLINICAL
EXCELLENCE,
INTEGRATION
RESEARCH
EDUCATION
– integration of UG and
PG education
– R&D management
into IOMS
– Research strategy
How are we going to fund this?
Research Strategy
• Focused on musculoskeletal system but full spectrum
Basic
science
Translational
Experimental
Clinical
trials
Health
services
research
• Five themes, building on track record and patient needs
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Innovative implant design
Cell therapy and tissue engineering
Disability and improvement of quality of life
Building the musculoskeletal evidence base
Sarcoma medicine
Tapping in to UCL
Basic
science
Translational
Experimental
 Innovative implant design
 Cell therapy and tissue
engineering
 Disability and improvement
of quality of life
 Building the musculoskeletal
evidence base
 Sarcoma medicine
Clinical
trials
Health
services
research
Musculoskeletal
Consortium
• Five centres in IOMS
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Bioengineering
Tissue engineering
Clinical academic
Rehabilitation
Pathology
Cancer Institute
Engineering
Centre for Ageing
Funding
UKCC
EPSRC
BBSRC
MRC
Basic
science
Translational
Experimental
ARC, charities
NIHR
Clinical
trials
Health
services
research
National Institute for Health Research
- the new research environment
• Concentration of funded clinical research in fewer,
larger centres
– Large research teams
– Epidemiology, health economics vital
– Many Trusts giving up and outsourcing research management
• Competition with all other specialities - fierce
– Priorities in cancer, neuro, endocrine, mental, children
– Role of rheumatology
• Research governance demands tighter
Transform or fade out
NIHR funding streams
• Comprehensive biomedical research centres
Specialist BMRCs
Biomedical Research Units
– Musculoskeletal in Oxford, Sheffield, Leeds
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Local Comprehensive Research Networks
HTA, RfPB, NEAT, RISC
Applied Research Programme Grants
Technology Support Board
MRC Translational Research Call
• £241m extra, most on translational research
– Bottlenecks
• Pan-UCL bid going in
– MRC Centre for Cell and Gene Therapy
• Stanmore hopefully to contribute
cell therapy in the musculoskeletal system
Cell-based therapy
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Clinical trials in ACI
Preclinical work on bone, collagen
Regenerative Medical Systems - UK
Translational teams
– Bone
– Tendon
– Cartilage
Stanmore Clinical Research Facility
• At present a joint venture between RNOHT
and UCLB – may change
• Goal is to facilitate rapid study design,
costing, governance and conduct
• Both investigator-led and commercial
– All must be fully funded
• Building a clinical research network is crucial
– eg fragility fractures and drugs that enhance
fracture healing
Research pipeline
in cell-based therapy
Basic
science
Translational
Experimental
Health
services
research
Clinical
trials
What phenotype of cultured cells
produces the best clinical response?
Is it cost-effective to culture-expand
cells rather than use bone marrow?
Can we design new way ways of
efficiently expanding stem cells?
IOMS
RMS-UK
SCRF
Integrated Academic Training
Programme
• Four Academic Clinical Fellows
• Two Clinical Lecturers
UCL Dean and
Research ViceProvost
UCL and Partners
Health Sciences
Research Deanery
Education
Committee
Trust Board
Academic
Research
Board
Research
Committee
PPI group
Research
Governance
Committee
Research Support Staff
• Academic Clinical Centre of IOMS
• MRC Clinical Trial Unit support
• Chair of Musculoskeletal Epidemiology
– Alex MacGregor – starting Sep 08
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R&D Director and Manager (Joseph Datukasi)
Nerina – Head of Academic Business Development
SCRF staff
IT systems for research support – Simon Grange
Research Governance
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MHRA inspection
Duties of Principal Investigators
Duties of RNOH as a sponsor
Our IT solutions
MHRA Inspection
MHRA Inspection
Support we can offer
• Training
– Executive GCP training
– Research Pack
– Best methodological practice in musculoskeletal research
• Governance
– Integration locally with Risk assessment
– Integration with Local Comprehensive Research Network
• Research
– Finding Research Partnerships
– Developing hypotheses and designing studies
– Finding funding sources
Research Governance
Clinical Trials Support
• Being tested by our iBSc & MSc students
Electronic Patient Record
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My tenure
Team building
Clinical Sen Lec
MSK epidemiologist
R&D Director
R&D Manager
Biostatistician
Health economist
IT/governance support
Medical physics
Joint academic strategy
capacity building
SCRF
Regenerative Medical
Systems - UK
Multidisciplinary MSc
Integrated Academic
Training Programme
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Expenditure
NHS R&D
UCL
Grant target
overheads, contributions to salary, SCRF profit
MRC stem cells in nonunion 300k
Pfizer fracture accelerating drug 500k
TSB grant 500k
NIHR Applied Research Programme £2m
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