Transcript Introduction to Geno..

Welcome
Introduction to Genomics
BL 3300/FW 3300
Essential Details
• Credits: 3
• Time: Monday, Wednesday and Friday
3 pm-4 pm
• Place: Forestry G002
• Class Paper:
– How will Genomics change my life?
• Note: Class paper presentations will be held
between December 4th and 8th, 2006.
Why was this course proposed?
Genomics is a new and very exciting area that
has witnessed many new conceptual and
technical advances. This information is vital to
our day to day living. Such a course would also
make our students competitive in current job
market
Bioinformatics majors needed this type of class
and now all molecular biology major will need it
too.
Course Description
• The main purpose of this course is to introduce concepts
of human genomics that can also be applied to microbial,
plant and animal genomes.
• The topics covered are
• Genes and genome organization
• Genome mapping
• DNA fingerprinting
• Gene tagging
• Bioinformatics
• Legal and Ethical aspects of genomics
• Genome evolution
Required Text Book
• Genomics
– Philip N. Benfey and Alexander D. Protopapas
(Pearson Prentice Hall)
(For 2006 updates go to
http://wps.prenhall.com/esm_benfey_genomics_1)
• 2005
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Recent book
Up to date
Real genomics book
Ready made slides and space for notes
Updates available
Additional Reading
• Optional Reading material (No need to buy it)
• Genomes by T.A. Brown, 1999, John Wiley & Sons, NY
• Genes VIII by Benjamin Lewin, 2003, Oxford University Press
• Molecular Biology by Robert F. Weaver, 1999, McGraw-Hill
Press
• Genome by Matt Ridley, Harper Collins, 2000
Grades
Grading Point System
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100-95
94-90
89-85
84-80
79-75
74-70
69-60
< 59
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AB
B
BC
C
CD
D
F
Course point distribution
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Class participation
Class paper
Mid-term
Final
10% (attendance, home work, quizzes, questions)
10% (essay and powerpoint presentation)
30%
50%
Who is your instructor?
• Shekhar Joshi (Chandrashekhar P. Joshi)
• Associate Professor of PMG, SFRES
• Over 20 years of research experience
– Molecular Genetics, Biotechnology, Bioinformatics
• 42 papers, 14 book chapters,65 presentations
• Teaching molecular genetics at MTU since
1998
Where and when can you find me?
• Room # 167, Forestry Building
• Office Hours: I am available between 9 am to 6
pm on all weekdays except
– Tuesdays 2-3 pm and Thursday 2-3 pm when I teach
FW5850 class and
– MWF between 3-4 when I teach this BL3300/FW3300
class.
• Phone: 906-487-3480
• Email: [email protected]
• Web site: http://forest.mtu.edu/faculty/joshi/
• For those who walk up from the main campus: Do call
me or email me before walking up the hill!
Class paper
• First, come up with a theme for your class paper
• You choose articles from the following magazines (or make
your own choice) and find out some interesting articles related
to Genomics that are published during last five years.
– Time, Life, Discover, Science, Nature, Scientific American,
Genetic Engineering News, National Geographic, US
News….
• Last Friday of every month, some of you will present to the
class which articles you have chosen and why? You will copy
up to ten such articles, review them and prepare a 20-minute
power point presentation that will be presented to the class
during the December 4th and 8th, 2006. Your peers and I will
evaluate your presentations.
• You will also write an essay (~10 pages long) based on all
such recent news items that you have collected and submit it
to me along with your Power point presentation by December
4th.
What is genomics?
Study of genomes
What is the genome?
Entire genetic compliment of an
organism
How many types of genomes
exist?
Prokaryotic genomes
Eukaryotic Genomes
Nuclear Genomes
Mitochondrial genomes
Choloroplast genomes
Why we should study genomes?
• Life’s little book of instructions
• DNA blue print of life!
• Human body has 1013 cells and each cell
has 6 billion base pairs (A, C, G, T)
• A hidden language determines which
proteins should be made and when
• This language is common to all organisms
What can genome sequence tell
us?
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Everything about organism's life
Its developmental program
Disease resistance or susceptibility
History
Where you are going?
How are human genomes
organized?
• 3% coding and rest of it junk (repetitive
DNA).
• Nuclear and mitochondrial
• You are 99.99% similar to your neighbor
Why human genome?
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We want to know about ourselves
How do we develop?
How do we struggle, survive and die?
Where are we going and where we came
from?
• How similar are we to apes, trees, and
yeast?
How will we change because of
Genomics?
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You will control the destiny of this planet
Big changes in our life
Biotechnology: more products
GMOs: More food-More problems?
Our society will not be the same
Individualized medicine
Gene therapy
Immortality? Disease free life?
Are we playing GOD?
Central dogma in Molecular Biology