Transcript Passing on genetic information from parents to children

Passing on genetic information
from parents to children
An explanation of autosomal
dominant inheritance
© 2013 NHS National Genetics and Genomics Education Centre
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk
• Here are some PowerPoint teaching slides which
demonstrate the transmission of an autosomal
dominant condition from parent to child; please feel
free to use these within your teaching
• Some parts of the animations run automatically;
others require a mouse click
• Most slides have notes with further information
© 2013 NHS National Genetics and Genomics Education Centre
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk
The 46 human
chromosomes seen
down the
microscope
Hundreds of genes are located on each chromosome
(The dark bands on the chromosomes are due to a special staining technique and are not genes as these are too
small to see)
© 2013 NHS National Genetics and Genomics Education Centre
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk
The 46 human chromosomes arranged in their 23 pairs (these are
the chromosomes of a normal male)
© 2013 NHS National Genetics and Genomics Education Centre
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk
Position of
particular gene
Chromosome
© 2013 NHS National Genetics and Genomics Education Centre
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk
Altered gene
Usual gene
Chromosome
© 2013 NHS National Genetics and Genomics Education Centre
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk
Autosomal dominant inheritance where one parent has the condition
Parents
Has
condition
Sperm or eggs
Autosomal dominant inheritance where one parent has the condition
Parents
Sperm or eggs
At conception
Autosomal dominant inheritance where one parent has the condition
Parents
Sperm or eggs
At conception
Has the condition
Has the condition
Does not have
the condition
Does not have
the condition
This is a family where raised cholesterol
is being inherited as an autosomal
dominant condition (familial
hypercholesterolaemia)
John Hall
Edith Hall
Died age 45 of
heart attack
Derek Hall
Faith
Wendy Hall
Joe
Robert Woods
Sophie
Benjamin
High cholesterol
High cholesterol
© 2013 NHS National Genetics and Genomics Education Centre
Carol Woods
James Hall
Died in 2005 of
heart attack
Takes medication for
high cholesterol
Matthew
Bryony
Hannah
Janet Hall
Jessica
Richard
High cholesterol
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk
This animation is part of a series describing
modes of inheritance
To access these and other resources for teaching and
learning genetics, please visit:
www.geneticseducation.nhs.uk
© 2013 NHS National Genetics and Genomics Education Centre
Genetics and genomics for healthcare
www.geneticseducation.nhs.uk