Transcript Trypanosoma evansi

Trypanosoma evansi
伊氏锥虫
CLASS 3
speaker:刘思玲
materials by吴云燕 张敏静 孙娜
ppt by刘务玲
• Introduction
• Morphology
• Life cycle
• Epidemology
• Symptoms
• Lesions
• Diagnosis
• Control
• Reference
Introduction
• What is Trypanosomosis/surra
disease?
(伊氏锥虫病/苏拉病)
A disease is
caused by
Trypanosoma
evansi（伊氏锥虫）
transmitted by
blood-sucking
insect(吸血昆虫)
Introduction
• Hosts:
cattle, goat , sheep, camel（骆驼），equines（马属动
物），dog, deer, elephant, tiger, rabbit, guinea pig(豚
鼠), rat, mice
• Site of infection:
blood, lymph(淋巴液)，ncurolymph（脑脊液）
distributed to tissues and organs through the blood
• Distribution:
Trypanosomosis is more common in tropical(热带) and
subtropical zone（亚热带）.
Morphology
• monomorphic in form（单
行型锥虫）
• willow-like(柳叶状)
• The nucleolus(细胞核) is
oval and lies in the
center of parasite.
• An free flagellum(一根游
离鞭毛)
• length：18~34μm
• width:1~2μm
Morphology
Life cycle
• blood-sucking insect as
mechanical transmission
vectors
• no cyclic development in
vectors
• reproduction: longitudinal
binary fission in blood, lymph
and blood-forming organs .
Epidemiology
Susceptible animals（易感动物）:
(1)mostly domestic animals and
wild animals ;
(2)Trypanosoma evansi in different
geographic area has different
hosts.
Epidemiology
Source of infection（传染来源）:
（1）animals infected
（2）animals with ever drug
treatment failed to kill the
pathogeny(病原)
4 Epidemiology
Route of infection(感染途径)：
• Tabanus(虻属) ： the most important vectors
• vampire bat(吸血蝠)
• carnivore(肉食兽) :infected by food
contained with Trypanosoma evansi.
• Incomplete disinfection surgical
instruments(消毒不完全的手术器械),
including injection equipment that used in
infected animals can disseminate infection
to the healthy ones.
Epidemiology
• Epidemiology season:
related to the activity season of
vector insects.
Symptoms
• The symptoms are different
based on different animals.
• Equines（马属动物）have stronger
susceptibility.
• Camels The disease is called camel flies
epidemic disease or the green dry
disease(骆驼伊氏锥虫病俗称，驼蝇疫，青干病)
• Cattles and buffloes The disease is a
typical course of chronic infection(慢性感
染).
Lesions
• Characteristic: subcutaneous
dropsy(皮下水肿)
• sometimes hydrothorax and ascites(胸
腔积液和腹水)
• Spleen(脾脏) and lymph node（淋巴结）
become enlarged.
• ecchymosis(出血斑) in gastric mucosal
of ruminated animals(反刍动物)
Diagnosis
• Collection of samples:
(1)blood from infected domestic animal
(2)skin exudation
(3)lymph node
• Examination
(1)Giemsa(吉姆萨染色)
(2)Microscopy（镜检）
(3)other: latex agglutination test(乳胶凝集试验)
Treatment
（1）Suramin(苏拉明)：intravenous injection
（静注）
（2）Quinapyramine(喹嘧胺):subcutaneous
injection（皮下注射）
（3）Diminazene aceturae(三氮脒)：
Subcutaneous injection or deep muscles
injection
（4）Isometamidium chloride(氯化氮胺菲啶盐酸
盐):deep muscles injection
（5）锥净 （Chinese medicine）
Prevention
(1)control vectors in case of their
contact with the hosts
(2)limit the activities of
recessive infection animals(隐性
感染动物)
(3)use drugs
Reference
• 《动物原虫病学》
• 《兽医寄生虫学》
蒋金书 编著
汪明 编著
Thank you!