Transcript AMS_PowerPoint_Pathophysiology_e

1. Cancer Associated Genes
2. Epigenetic Mechanisms
3. Molecular and Cellular Pathways
4. Tumour Cell Transformation
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Porth, C.M. 2011. Essentials of Pathophysiology, 3rd Edn.
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Porth, C.M. 2011. Essentials of Pathophysiology, 3rd Edn.
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Heredity
Hormones
Obesity
Immunologic Mechanisms
Chemical carcinogens
Radiation
Viral and microbial agents
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1. Anorexia and Cachexia
2. Fatigue and Sleep Disorders
3. Paraneoplastic Syndromes
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Describe the phases of cell cycle.
Differentiate between cell proliferation and cell differentiation.
Cancer is a disorder of altered cell __________ and _________.
Malignant tumours are less well _____________ and have the
ability to break __________, enter the _______________ or
_______________ systems and form secondary malignant
tumours at other sites.
Compare and contrast benign tumours and malignant
tumours.
What is paraneoplastic syndrome?
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Genetic disorders are inherited as autosomal dominant
disorders, in which each child has a 50 percent chance
of inheriting the disorder, or as autosomal recessive
disorders, in which each child has a 25 percent chance
of being affected, a 50 percent chance of being a
carrier, and a 25 percent chance of being unaffected.
2. Sex-linked disorders almost always associated with the
X chromosomes and are predominately recessive.
3. Chromosomal disorders reflect events that occur at the
time of meiosis and result from defective movement of
an entire chromosome of from breakage of a
chromosome with loss or translocation of genetic
material.
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1. Single defective or mutant gene.
2. Lead to formation of an abnormal
protein or decreased production of a
gene product.
3. The disorder can result in a defective
enzyme, defects in receptor
proteins and their function or
mutations resulting in unusual
reactions to drugs.
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