Transcript Pharm II - 2-18

INTRO TO CNS
DRUGS
B Y A L A I N A DA R B Y
Which of the following is part of the diencephalon?
a. Hypothalamus
b.Medulla
c. Pons
d.Basal ganglia
Which of the following is not part of the limbic
system?
a. Amygdala
b.Mammillary bodies
c. Substantia nigra
d.Orbitofrontal cortex
Which of the following is properly paired?
a. Cingulate cortex – memory
b.Hippocampus – autonomic, endocrine
c. Nucleus accumbens – spatial memory
d.Cingulate cortex – autonomic, attention,
cognition
Which of the following portions of the brain is
responsible for sleep, wakefulness, arousal and eye
movements?
a. Thalamus
b.Hypothalamus
c. Midbrain
d.Basal ganglia
What is the main role of the basal ganglia?
a. Emotion
b.Learning
c. Motor control
d.Cognition
Which of the following types of channels are not
found in neurons?
a. Mechanosensitive channels
b.Voltage gated channels
c. Cyclic nucleotide gated channels
d.Ligand gated channels
Which of the following is a peptide
neurotransmitter?
a. Endocannabinoid
b.GABA
c. Norepinephrine
d.Neurotensin
Which of the following is true?
a. Metabotropic receptors rely on second
messengers
b.Ionotropic receptors have 7 transmembrane
domains
c. Metabotropic receptors are transmembrane
channels
d.Ionotropic receptors open or close in response to
ions
Which of the following does not directly influence
the synthesis or metabolism of dopamine?
a. COMT
b.Reserpine
c. MAO
d.L-DOPA
Which of the following would be considered a form
of neurotransmitter antagonism?
a. Black widow spider venom
b.Nicotine
c. Reserpine
d.Cocaine
Which of the following would result in
neurotransmitter agonism?
a. Drug blocks autoreceptors
b.Drug inactivates synthetic enzyme
c. Drug prevents storage of neurotransmitter in
vesicles
d.Drug blocks postsynaptic receptors
Which of the following is not a primary use of
stimulants?
a. Anorexic
b.Treatment for ADHD
c. Antiemetic
d.Treatment for narcolepsy
Which of the following is true of cocaine?
a. Crack is the powder form of the drug
b.It can act as a local anesthetic
c. It causes hypotension
d.It causes the release of neurotransmitter
Which of the following is more potent than
cocaine?
a. Benzoyleconine
b.Cocaethylene
c. Benzoic acid
d.Dexeconine
Which of the following is the reward portions of the
brain takes over in substance abuse?
a. Prefrontal cortex
b.Nucleus accumbens
c. VTA
d.Basal ganglia
John is 53 and has just been diagnosed with ADHD.
He became addicted to cocaine when he was
younger but has since been able to quit. Which of
the following drugs is best suited for him?
a. Amphetamine
b.Methylphenidate
c. Atomoxetine
d.Lisdexamfetamine
Which of the following is a true comparison of
mazindol and cocaine?
a. Mazindol is more selective for norepinephrine
b.Cocaine is more selective for norepinephrine
c. Cocaine causes neurotransmitter release while
mazindol causes transporter blockade
d.Mazindol causes neurotransmitter release while
cocaine causes transporter blockade
Steve is looking to start taking mazindol for his
obesity. Which of his current drugs would not cause
an interaction with mazindol?
a. Tranylcypromine
b.Guanethidine
c. Cimetidine
d.Amitriptyline
Samantha is pregnant. Which of the following
stimulants might induce premature labor, if she
were to use it?
a. Cocaine
b.Mazindol
c. Amphetamine
d.Methylphenidate
Which of the following adverse reactions is the
most distinguishing for amphetamine among other
stimulants?
a. Headache
b.Confusion
c. Neurotoxicity
d.Restlessness
Which of the following is thought to have the
lowest risk of abuse since it causes less of a surge of
dopamine?
a. Amphetamine
b.Methamphetamine
c. Lisdexamfetamine
d.Methylphenidate
Jake is on a high dose of amphetamine for his
ADHD and accidentally took his medication three
times this morning. Which of the following
treatments would he not need to treat the
described symptoms from this poisoning?
a. Aluminum chloride to increase elimination
b.Sedative for the resulting anxiety
c. Sodium nitroprusside to reduce hypotension
d.Acidification of his urine to neutralize the
amphetamine
How does methylphenidate differ from
amphetamine?
a. Side effects
b.Abuse potential
c. Mechanism of action
d.Usefulness for narcolepsy and ADHD
Casey needs to lose weight before her wedding in a
few weeks and has asked her doctor what she could
take to increase her weight loss. Which of the
following might he prescribe since she will only be
taking it for a short time?
a. Modafinil
b.Amphetamine
c. Phentermine
d.Mazindol
Which of the following would be effective to treat a
narcoleptic that has a history of drug abuse?
a. Amphetamine
b.Methylphenidate
c. Modafinil
d.Atomoxetine
What might be a reason to select a medication
other than modafinil to treat narcolepsy?
a. Cardiovascular problems
b.GI problems
c. Frequent headaches
d.Past addiction
How does nicotine cause addiction?
a. Blocking dopamine reuptake
b.Acting on the dopaminergic neurons
c. Activating dopamine receptors
d.Blocking presynaptic dopamine receptors
Which of the following drugs would be least likely
to interact with varenicline?
a. Insulin
b.TCA’s
c. Blood thinners
d.Asthma medications
Which of the following would be most beneficial to
someone who is depressed and wants to quit
smoking?
a. Nicotine patch
b.Nicotine gum
c. Varenicline
d.Buproprion
Which is not a mechanism of action for caffeine?
a. Blocking dopamine and norepinephrine reuptake
b.Adenosine receptor antagonism
c. Phosphodiesterase inhibition
d.Increasing dopamine and norepinephrine release
Which of the following is true of ephedrine?
a. It is used for narcolepsy, depression, and as a
bronchodilator
b.It undergoes extensive metabolism in the liver
c. It decreases dopamine and norepinephrine
reuptake
d.It may cause hypotension and insomnia
Which of the following antagonizes the receptor for
an inhibitory amino acid neurotransmitter?
a. Nicotine
b.Modafinil
c. Cocaine
d.Strychnine
How might one treat strychnine poisoning?
a. Aluminum chloride
b.Diazepam
c. Sodium nitroprusside
d.Benztropine