Transcript Matt Jung- Right board

Discussion
Supports Seeman’s studies 1975 in 2005.
Receptors expressed better with mutations in the first
protomer with beta gamma biosensor.
Receptors expressed better with mutations in the second
protomer with the Alpha biosensor.
Proteins and receptors may not have been transfected
properly.
Seeman P. et.al. PNAS 2005;102:3513-3518
Figure 10: Data table from Seaman's most recent study. He treated
D2 receptors with Olanzapine and observed an increase in the
amount of receptors in the D2 High states.
Conclusion
Receptors continued to express despite
inhibitons
Supports the Dopamine hypothesis of
Schizophrenia
Supports Seeman’s studies in 1975 and
2005
Future Research
Deletion in one of the
transmembrane receptors
FACS Assay
http://www.smbs.buffalo.edu/confocal/array.jpg
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