Transcript Lorenzo’s Oil - Ramsey Public School District

Lorenzo’s Oil
Obectives: To demonstrate understanding of…..
1. How Lorenzo inherited the disease through genetic
inheritance.
2. How a disease is the result of a malfunctioning
system, organ, and cell.
3. The importance of proteins to the normal breakdown
of fatty acids.
4. The implications of abnormal metabolic functioning
in ALD patients.
5. Fatty acid manipulation as a therapeutic treatment in
ALD patients using Lorenzo’s oil.
6. Ethical implications demonstrated by the Lorenzo
Odone story.
Lorenzo’s Oil
Obectives: To demonstrate understanding of…..
1. How Lorenzo inherited the disease
through genetic inheritance.
-
What is a sex-linked gene?
Why do sex linked disorders affect males more often?
Which parent passed the defective gene to Lorenzo?
Why don’t Lorenzo’s parents suffer ALD?
What was the defective gene responsible for? (What was
it suppose to code for?)
- Illustrate how Lorenzo inherited ALD using a punnett
square.
- See 9.21 & 9.22 in text for additional help.
Lorenzo’s Oil
2. How is ALD the result of a malfunctioning
system, organ, and cellular level?
Organ System Level:
What organ system is failing? Why is it failing?
Organ Level:
What organ is failing? Why is it failing?
Cellular Level:
What is happening at a cellular level that causes cell
destruction? Why is this happening?
Lorenzo’s Oil
3. The importance of proteins to the
normal breakdown of fatty acids.
- What type of proteins are involved in ALD?
- How are enzymes involved in ALD?
- How does competitive inhibition in enzyme
activity help reduce the biosynthesis of
VLCFA?
Lorenzo’s Oil
4. The implications of abnormal metabolic
functioning in ALD patients.
Metabolic Pathway: A series of chemical rxns that either
builds a complex molecule or breaks down a complex molecule
into smaller units.
• Describe ALD in terms of a malfunctioning metabolic
pathway.
• Explain why diet alone cannot help ALD patients in terms of
biosynthesis?
Lorenzo’s Oil
5. Fatty acid manipulation as a therapeutic
treatment in ALD patients using Lorenzo’s oil.
Lorenzo’s oil is a mixture of oleic acid (from olive oil) and
erucic acid (extracted from rapeseeds).
• How are these oils used as a treatment? Discuss answer in
terms of competitive inhibition in enzyme activity and
biosynthesis.
• Why don’t these oils harm ALD patients?
• How do these oils differ structurally from the fatty acids
that build up in ALD patients?
Lorenzo’s Oil
6. Ethical implications demonstrated by the
Lorenzo Odone story.
The process of finding medical treatments for people
(clinical trials) often puts sound scientific processes
(repeating trials; having control groups; taking time for
peer review) against human morales (helping those
who suffer). How is this highlighted in Lorenzo’s story?
Be able to give specific examples.
Long Chain Fatty Acids & ALD
VISIT this site
• http://clasfaculty.ucdenver.edu/bstith/loren.htm
The Myelin Project
Play slide show
• http://www.myelin.org/resources/toolsforteache
rs.html
• http://www.myelin.org/ - Link to Lorenzo’s Oil