Transcript Public Health Genomics and International Activities Prof

PAOG nascholing Jeugdgez
Maastricht, 25 Janua
Tomris Cesuroglu, MD
Institute for Public Health Genomics
Research into
Child Health
in Europe
RICHE
http://childhealthresearch.eu
http://childhealthresearch.eu
RICHE
An EU funded project (FP7, Mar 2010 to Feb 2013)
A project for child health researchers, practitioners,
policy makers, and those who make decisions
affecting children
Defining the current pattern of child health research
in Europe, seeing what's not being done, and
identifying paths to the future of the research
Future proofing child health research policy in Europe
Meeting the future needs of European policy makers,
funders, and children.
http://childhealthresearch.eu
Home Page
http://childhealthresearch.eu
An example
http://childhealthresearch.eu
What's to be done?
Join us!
Put up your
Put up your
Put up your
Put up your
Put up your
own work
colleagues
projects
report
funders
http://childhealthresearch.eu
Perspectives in Personalized Health Care
Tomris Cesuroglu, MD
Institute for Public Health Genomics
PAOG nascholing Jeugdgezondheidszorg
Maastricht, 25 January 2011
1% of burden
of disease
22% of burden
of disease
77% of burden of
disease
Disease
________________________________________
threshold
Life style
External
factors
Genetic
structure
Genetic diseases
External factors
*Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research
Complex
diseases
An Example to a
Single Nucleotide Polymorphism
(SNP)
Start
Codon
Stop
Codon
┐└
TAT
ATA
TCG
AGC
TAC
ATG
GGC
CCG
TAC
ATG
ATA
TAT
CGT
GCA
ACC
TGG
GTA
CAT
AAT
TTA
TCG
AGC
ATT
TAA
CGA
GCT
TGA
ACT
┐└
An Example to a
Single Nucleotide Polymorphism
(SNP)
Start
Codon
Stop
Codon
┐└
TAT
ATA
TCG
AGC
TAC
ATG
GGC
CCG
TAC
ATG
ATA
TAT
CGT
GCA
GCC
CGG
GTA
CAT
AAT
TTA
TCG
AGC
ATT
TAA
CGA
GCT
TGA
ACT
┐└
Gene and Environment/Life Style Interaction
Genetic Polymorphism
Dark skin
Fair skin
Which one is better?
*Slide series used with the courtesy of GENAR Institute for Public Health and Genomics Research
Genetic variation: Is it good or bad?
Fair skin
Norway
Nigeria
Dark skin
Happily
living in
Fjords
Happily
living
under
African sun
Genetic variation: Is it good or bad?
Fair skin
Norway
Nigeria
Dark skin
Genetic variation: Is it good or bad?
Fair skin
Norway
Nigeria
•Gets red
•Burns
•Melanoma
develops
Dark skin
Genetic variation: Is it good or bad?
Fair skin
•Not enough
sunshine
•Vitamin D
deficiency
•Develops
osteoporosis
Norway
Nigeria
Dark skin
•Gets red
•Burns
•Melanoma
develops
Genetic variation: Is it good or bad?
Fair skin
•Not enough
sunshine
•Vitamin D
deficiency
•Develops
osteoporosis
Norway
Nigeria
Dark skin
Positive
intervention:
Protecion
from the sun
Genetic variation: Is it good or bad?
Fair skin
Positive
intervention:
Vitamin D
supplements
Norway
Nigeria
Dark skin
Positive
intervention:
Protecion
from the sun
Eric
Assamoa
Transcription (mRNA production)
Transcription (mRNA production)
Translation in ribosom
(synthesis of amino acid chain)
Translation in ribosom
(synthesis of amino acid chain)
Protein
GSTP 1
Effective detoxification
GSTP 1
(A313G Homozygous)
Protein
Ineffective detoxification
Disease Threshold
Early Symptoms Threshold
Check-Up
Early
Diagnosis
Diagnosis
and
Treatment
Death
Conception
Life Style and Environmental Conditions
Genetic Predisposition
Pathology Development
Phase I
*Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research
Early
Disease
Symp. Phase III
Phase II
Thank you for your attention!
Tomris Cesuroglu, MD
[email protected]