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Chain arrangements and Interactions 14 C : 5 O : 1 N, acrylate terminated alternating macromer H-bonding potential in oxygen groups Hydrophobic interactions from isobutyl group Steric hindrance / entanglement 1.2:1 ratio of diacrylate:amine Structure / Morphology Linear macromer Susceptible to polar, H-bonding, organic solvents Chemically or UV crosslinked to form hydrogel Free radical polymerization reaction This specific polymer is densely crosslinked Forms a flexible solid Physical Properties of A6 • Modulus of 25 Mpa, which is similar to the moduli for elastomers and nonbiodegradable polyurethanes. • Total degradation time was greater than three months • Generally hydrophobic gel and exhibits low swelling in aqueous conditions. Figure 1: Degradation time for four separate poly(β-amino ester). The percent mass loss was measured over the course of 100 days. Additives PEGylation Increase hydrophilicity ‘Stealth’ drug carrier Iron oxide nanoparticles Remote degradation Drugs! Hydrophobic drugs = slow, degradation and diffusion-based release Hydrophilic drugs = rapid, diffusive release Porogen Source comparison Internet – Great for journal articles. Difficult to find monomer properties and reaction information SciFinder Scholar – monomer properties, journal articles. Do not have to sift through “bad” references. Polymer Handbook (4th Ed): index of monomer properties, including CAS registry #. Slower to use then SciFinder or internet, but more convenient once you have the actual book Bio True Contact Solution Ingredient Toxicity Purpose Hyaluronan Mild Forms highly hydrated matrices. Also a natural component of the vitreous humor of the eye. Sulfobetaine Mild Used as a surfactant. Poloxamine Mild Surfactant Boric Acid Mild Relieves irritation, very dilute. Sodium Borate Mild pH buffer Edetate Disodium Mild Chelating agent Sodium Chloride Mild Hydrating agent Poly(amino propyl Biguanide) Mild Disinfectant Poly(quaternium) Mild Antimicrobial and positive charge neutralize negative charges Works Cited Hawkins, A.M., et al. “Synthesis and analysis of degradation, mechanical and toxicity properties of poly(Beta-amino ester) degradable hydrogels.” Act Bio 7-5, 2011 (1956- 1964) Anderson, D.G., et al. “A combinatorial library of photocrosslinkable and degradable materials.” Adv Mat 18, 2006 (2614-2618) Brandrup, J.; Immergut, Edmund H.; Grulke, Eric A.; Abe, Akihiro; Bloch, Daniel R. (1999; 2005). Polymer Handbook (4th Edition).. John Wiley & Sons. Necas, J, L Bartosikova, P Brauner, and J Kolar. "Hyaluronic acid (hyaluronan): a review." Veterinarni Medicina. 53. (2008): 397-411. Print. <http://www.vri.cz/docs/vetmed/53-8397.pdf>. "Material Safety Data Sheet." Amresco. N.p., 10-May-2011. Web. 21 Sep 2011. <http://www.amrescoinc.com/media.acux?path=/media/products/msds/MSDS-J548.pdf>. "POLOXAMINE 1307." EWG's Skin Deep. Environmental Working Group, 2011. Web. 21 Sep 2011. <http://www.ewg.org/skindeep/ingredient.php?ingred06=722350>. "Edetate Disodium (Systemic)." Drugs.com. N.p., 02-09-2000. Web. 21 Sep 2011. <http://www.drugs.com/mmx/edetate- disodium.html>.