Transcript No Slide Title

From sceptic to practitioner:
Rediscovery of Physiology First
The Alkaline Way to restore enhance
or protect health
Russell Jaffe, MD, Ph.D., CCN, NACB,
FASCP, FACN, FACAAI, FAMLI, FOCIS, FRSM
Fellow, Health Studies Collegium
Director, ELISA/ACT Biotechnologies, LLC.
Director, PERQUE, LLC.
Personal journey from
Submolecular reductionism
st
to Physiology 1 Principles &
Alkaline Way Practices:
st
1 stop: Occult Blood tests for
colon cancer detection
Occult Blood as Colon Cancer Screening test:
Jaffe RM, Kasten B, Young DS, MacLowry JD.
False-negative stool occult blood tests caused by
ingestion of ascorbic acid (vitamin C). Ann Intern Med.
1975 Dec;83(6):824-826.
D.K. w/ unexplained anemia, ascorbic acid ingestion & 472 negative stool
occult blood tests. Off ascorbic acid, her stools became strongly reactive
("4+") by 3 tests for occult blood; association observed repeatedly. A new test
developed to measure stool occult blood in the presence of ascorbic acid
remained reactive throughout observation… Current tests for occult blood
depend on the pseudoperoxidase activity of heme & are inhibited by low
levels of ascorbic acid. Reducing substances chemically similar to ascorbic
acid also inhibits occult blood tests; oxidized ascorbic acid and sulfhydryl
reducing agents do not inhibit them at physiologic levels.
C D Griffith, D J Turner, and J H Saunders. False-negative results of Hemoccult test in colorectal cancer.
Br Med J (Clin Res Ed). 1981 August 15; 283(6289): 472
False negative occult blood tests do not no
blood loss… maybe test is wrong. More precise
tests are more sensitive (fewer false positives), specific (fewer
false negatives) & predictive(more true positives).
New more sensitive test reduced
cost / colon cancer detected
from $240,000 to $14,000 (1975 $)
Jaffe R, Zierdt W. An Occult Blood Test Procedure not Subject to Inhibition by Reducing
Substances. J. Lab. Clin. Med. 1975; 93: 879-886.
Personal journey to
st
1
Physiology
The Alkaline Way
nd
2 stop:
Collagen cross links &
d-penicillamine
Elastin stretches
&
relaxes like
rubber band
Collagen fibrils in
extracellular space
orient cells; provide
bio-architecture matrix;
piezoelectric coiled coil
Science, 2 August 1968: Vol. 161 # 3840, pp. 475 – 476
Desmosine Biosynthesis: Nature of Inhibition by D-Penicillamine
1
1
1
S. R. Pinnell , G. R. Martin , and E. J. Miller
National Institute of Dental Research, Bethesda, Maryland 20014
“Administration of D-penicillamine & lathyrogens
such as ß-amino-propionitrile markedly alters connective tissue by preventing normal cross-linkage of
elastin & collagen…. ß-aminopropionitrile blocks cross-linkage of elastin & collagen by preventing
initial step in cross-linkage: Lysine in peptide linkage converts to amino adipic-semialdehyde.
We show that penicillamine acts after initial step, causing accumulation of elastin rich in amino adipicsemialdehyde”.
My thesis worked out d-penicillamine’s mechanism of action in blocking elastin & collagen
cross-links
Jaffe R. Mechanism of Cross-Linkage Inhibition by Penicillamine, in Texas Reports on Biology and Medicine,
Spring, l971; MSD Awardee.
Franzblau C, Faris B, Salcedo L, Jaffe R, & Crombie G.
Chemistry and Biosynthesis of Cross-links in Elastin.
In Chemistry and Molecular Biology of the Extracellular Matrix
(Balazas, Ed.) Academic Press, 1970, p 617-641.
Helpful in
establishing
pulsed d-pen
protocol
for safer
toxic metal
detection &
removal from
body 15 years
later
Franzblau C, Faris B, Salcedo L, Jaffe R, & Crombie G.
Chemistry and Biosynthesis of Cross-links in Elastin.
In Chemistry and Molecular Biology of the Extracellular Matrix
(Balazas, Ed.) Academic Press, 1970, p 617-641.
Helpful in
establishing
pulsed d-pen
protocol
for safer
toxic metal
detection &
removal from
body 15 years
later
Personal journey to
st
1
Physiology
rd
The Alkaline Way, 3 stop:
Platelet activation by
collagen
J Clinical Investigation, 1974; 53: 875-883
√ Worked out…
• How collagen aggregates platelets: 4º action
• How to block platelet aggregation
w/ monomeric collagen; quaternary property
• Quantified number of binding sites
on platelet for collagen
• Developed dose-response platelet aggregation
• Collaborated with Fry & Mahley of NHLBI
on animal models of human heart disease:
√ distress √ oxidized cholesterol or EFA
√ immune reactions; √ vulnerable plaque;
cholesterol & triglycerides innocent bystanders
Personal journey to
st
1 principles
Physiology
thth
Alkaline Way, 4 7 stops:
Mindfulness, TCM,
Ayurveda, homeopathy:
remove obstacles to health
Bhante Dharmawara: 20+ years mindfulness,
vipassana & buddhology sangha; color healing
TCM: 7 years with Xing Wu;
translate Nan Xing; OMSWMP
Ramamurti Mishra, MD, PhD
12 years in Patanjali’s sutras;
Textbook Yoga Psychology;
Self Awareness, Self Knoweldge
Abdul Aziz Said: 20+ years
mindfulness, Sufi circle
Jon Young, Tom Brown:
Regenerative design,
nature & wilderness awareness
Physiology
st
1 …
Alkaline Way: PFAW
 Health Synthesis:
Use Physiology & Pharmacognosy
before Pharmacology;
Remove obstacles to recovery & use best
benefit / risk for what remains
Jaffe R, Towsend Letter, January 2009, p80-89 &
Diabetes & Food Allergy Chapters in Food and Nutrients in Disease Management
Ingrid Kohlstadt (Ed ), CRC Press/Taylor & Francis Group, 2009, 717 pp, $149.95
www.elisaact.com/pdfs/EAB_LabComp_Reliability.pdf
Physiology
st
1 …
Alkaline Way: PFAW
 Studies to restore health / show sustained
remissions in… diabetes (p<0.01), fibromyalgia
(p<0.05), Adrenal stress (p<0.001), 50,000 cases
in database; AI result interpretation
Jaffe R, Towsend Letter, January 2009, p80-89 &
Diabetes & Food Allergy Chapters in Food and Nutrients in Disease Management
Ingrid Kohlstadt (Ed ), CRC Press/Taylor & Francis Group, 2009, 717 pp, $149.95
www.elisaact.com/pdfs/EAB_LabComp_Reliability.pdf
PsychoNeuroImmunoHormone GV

Endocrine
Neuro-
Immune
Hormone
chemical
repair
Homeostasis… Alkaline Way: PFAW
 Healthy neuro-immuno-hormone function =
ample capacity to neutralize
‘foreign antigens’ keeps tolerant immune responses
 No Delayed allergy / hypersensitivities
Tolerance, better digestion, & hydration
Jaffe R, Mani J, DeVane J, Mani H. Tolerance loss in diabetics: Association with
foreign antigen exposure. Diabetic Medicine: A Journal of the British Diabetic
Association 2006 Aug;23(8): 924-925.
Use in clinical practice: PFAW
what we eat, drink,
think & do…
determines who we are
Jaffe, R. Functional Lab Tests to Evaluate Immune Competencies in Chronic
Illness and Chronic Infection: Part 1. Townsend Letter for Doctors and Patients
2006; Jan: 87-89 and Part 2 (Feb/Mar) 107-109.
Eat: Ingest, assimilate, eliminate
Foods we can beneficially digest, take up,
utilize & excrete without food allergies,
sensitivities or intolerances; nutrient dense,
uncontaminated, vine ripened in modified mesosino-indo-thai-mediterranean healthy diet
The Joy of Eating The Alkaline Way,
th
18
edition, Health Studies Collegium, Ashburn, VA 20147.
Available from EAB (1.800.553.5472) or PERQUE (1.800.525.7372)
Eat: Calories balanced by activity
Foods we beneficially digest to reverse or
prevent food allergies (RAST™, IgE), sensitivities
[LRA by ELISA/ACT™]
deficiency);
or intolerances (lactase
Organic or biodynamic CSA or
farm market or edible landscape
The Joy of Eating The Alkaline Way,
th
18
edition, Health Studies Collegium, Ashburn, VA 20147.
Available from EAB (1.800.553.5472) or PERQUE (1.800.525.7372)
Eat: Sufficient nutrients to fuel
Antioxidants prevent oxidative stress
& inflammatory, repair deficit ills:
√ Ascorbate calibration (C Flush)
√ Metabolic acidosis
st
(1
AM Ur pH)
√ d-pen (Essential & Toxic Minerals)
√ Food effects on body chemistry
The Joy of Eating The Alkaline Way,
th
18
edition, Health Studies Collegium,
Ashburn, VA 20147. Available from EAB (1.800.553.5472) or
PERQUE (1.800.525.7372)
Eat: Alkaline Way Worldwide Health
 Practical guide: Identify personalized diet
 Restore tolerance & self-regulation





Reset immune responses
Body forgives and remembers
Homeostasis restored
Once reactive NOT always so
Program best when followed
Ecological Intelligence by Dan Goleman, Broadway Books, 2009
Eat: Alkaline Way Worldwide Health
 Practical guide: Identify personalized diet
 Restore tolerance & self-regulation





Reset immune responses
Body forgives and remembers
Homeostasis restored
Once reactive NOT always so
Program best when followed
Eat: source of nutrients & wholeness
People dig their graves with their
forks. 2,000 year old man, Mel Brooks
Of starvation I saw few die, of over
eating a 100,000. Ben Franklin
The Joy of Eating The Alkaline Way,
th
18
edition, Health Studies Collegum, Ashburn, VA 20147.
Available from EAB (1.800.553.5472) or PERQUE (1.800.525.7372)
Drink: source of water & minerals
Drink hard water: > 1 g (1,000 mg)
dissolved solids (minerals) / liter
Avoid soft plastic bottles
Test your water or play roulette
watertest, 33 Third Street, Suite 102, Bordentown, NJ 08505
Please e-mail your questions to [email protected]
or you can call 609.291.9072 or 800.715.0454
Drink: Test of hydration status
Pinch skin on back of palm, release
& watch how quickly skin goes flat.
>1 sec (quick) for tented
skin to go flat at any age,
drink 8-12 oz water &
repeat in 30’; observe.
RussMD.Blog.com/hydration or www.PERQUE.com or www.ELISAACT.com
Think: Mental exercises & mindfulness
Use body’s control system: NIH = GV
 Therapeutic biofeedback (Pat Norris)
 Vipassana or Active Meditation
(Bhante Dharmawara, Bob Leichtman)
 Mindfulness practices
(Howard Zinn, Dan Goleman)
 Evoke human healing responses:
Key to all other therapy’s success


Companionable with all integrative therapies
Do: Exercises, rest & recreation
Move youthfully (Bonnie Pruden)
 Sensation as teacher (Milton Trager)
 Continuous breath
(Rudy Balentine, Swami Ajaya)
 Breath as refuge; light mood modulation
(Patanjali, Ramamurti Mishra)
 Core strength, rotation, weight bearing
Do the movements you enjoy; keep moving


Companionable with all integrative therapies
Do: Exercises, rest & recreation
Move youthfully (Bonnie Pruden)
 Sensation as teacher (Milton Trager)
 Continuous breath
(Rudy Balentine, Swami Ajaya)
 Breath as refuge; light mood modulation
(Patanjali, Ramamurti Mishra)
 Core strength, rotation, weight bearing
Do the movements you enjoy; keep moving


Companionable with all integrative therapies
Do: Exercises, rest & recreation
Move youthfully (Bonnie Pruden)
 Sensation as teacher (Milton Trager)
 Continuous breath
(Rudy Balentine, Swami Ajaya)
 Breath as refuge; light mood modulation
(Patanjali, Ramamurti Mishra)
 Core strength, rotation, weight bearing
Do the movements you enjoy; keep moving


Companionable with all integrative therapies
Physiology First Alkaline Way: PFAW
 Health = Enhancement Factors - Erosion Factors

Helpful; good (Nutrition, activity, attitude)

Nutrition: Wholeness + adequacy of repair & detox factors
Activity: Living in harmony with your nature and needs
Mental Attitude: Cultivated internal equanimitas


Physiology First Alkaline Way: PFAW
 Health = Enhancement Factors - Erosion Factors

Helpful; good (Nutrition, activity, attitude)

Nutrition: Wholeness + adequacy of repair & detox factors
Activity: Living in harmony with your nature and needs
Mental Attitude: Cultivated internal equanimitas


- Unhelpful; bad (Deficits, toxins, distress)



Deficits: Dietary taxes of high tech living
Toxins: Toxic minerals, solvents, biocides, pseudoestrogens
Distress: Mental erosion from learned anxiety/conflict
Jaffe R, Morris E. Medicine in Transition, HSC report, 1990.
Physiology First Alkaline Way: PFAW
 Health = Enhancement Factors - Erosion Factors



Helpful
(Nutrition, activity, attitude)
Nutrition: Nutrient density, variety, and sufficient essentials
Activity: Move, stretch, bear weight joyfully
Attitude: Active meditation, internal dialogue
Physiology First Alkaline Way: PFAW
 Health = Enhancement Factors - Erosion Factors
Helpful

(Nutrition, activity, attitude)
Nutrition: Nutrient density, variety, and sufficient essentials
Activity: Move, stretch, bear weight joyfully
Attitude: Active meditation, internal dialogue

- Unhelpful (Deficits, toxins, distress)


Deficits: Nutritional borrowing leaves overdrafts

Toxins: Pb, Hg, Ar, Ni, Cd, Al, chlorinated...,
biocides: pesticides & antibiotics = pseudoestrogens

Distress: What is and what is ours to change
Biodetoxification in clinical practice, HSC protocol, 1989-2010.

Physiology First Alkaline Way: PFAW
 Loss of Tolerance from toxin, diet deficits, stress
Overload of acquired foreign reactive ‘Antigens’
[infectious & non-infectious handled identically!]
 Gel and Coombs (1967) described immune types:




Type 1:
Type 2:
Type 3:
Type 4:
,
Descotes J,
Immediate, acute allergy; IgE; RAST
Humoral delayed allergy; IgM, IgG, IgA
Immune complex reactions; IgM anti-IgG Ag
Cell-mediated responses; T cells
Choquet-Kastylevsky G. Gell and Coombs's
classification: is it still valid? Toxicology, 2001; 158(1-2): 43-49.
st
1 …
Physiology
Alkaline Way: PFAW
 Healthy immune function:
Protective homeostatic factors:
 Five lines of 1º innate defense
No delayed allergy / hypersensitivities = tolerance;
Re-balance = homeostasis
Jaffe, R. First Line Comprehensive Care. Part II: Anthropogenic Xenobiotics in
Functional Medicine. Managing Persisting Bioaccumulating Pollutants: Toxic
Minerals, Biocides, Hormone Mimics, Solvents, and Chemical Disruptors. Seminars
in Integrative Medicine 2005 (Sep) 3(3): 79-92.
st
1 …
Physiology
Alkaline Way: PFAW
 Healthy immune function includes
Protective homeostatic digestive factors:
1. Mucin
trappers
2. Secretory IgA (sIgA)
binders
3. Probiotic microflora
metabolizers
4. Mucosal permeability barrier excluders
5. Dendritic first responders
engulfers
st
1 …
Physiology
Alkaline Way: PFAW
 Healthy immune function includes
Protective homeostatic digestive factors:
1. Mucin
trappers
2. Secretory IgA (sIgA)
binders
3. Probiotic microflora
metabolizers
4. Mucosal permeability barrier excluders
5. Dendritic first responders
engulfers
st
1 …
Physiology
Alkaline Way: PFAW
 Healthy immune function includes
Protective homeostatic digestive factors:
1. Mucin
trappers
2. Secretory IgA (sIgA)
binders
3. Probiotic microflora
metabolizers
4. Mucosal permeability barrier excluders
5. Dendritic first responders
engulfers
st
1 …
Physiology
Alkaline Way: PFAW
 Healthy immune function protects and
you can impact physiology for the better:
1. Mucin
trappers
2. Secretory IgA (sIgA)
binders
3. Probiotic microflora
metabolizers
4. Mucosal permeability barrier excluders
5. Dendritic first responders cells engulfers
st
1 …
Physiology
Alkaline Way: PFAW
 Thrive with ‘5 alive protocol’:
1. Alkaline balance
1st AM Ur pH
2. Antioxidants
Ascorbate calib.
3. Relaxation response GSR; skin temp
4. Mucosal permeability
5. Dendritic
st
1
responders
Glutamine PAK
Quercetin/OPC
info: RussMD.Blog or 1.800.553.5472
st
1 …
Physiology
Alkaline Way: PFAW
 Thrive with ‘5 alive protocol’ goals:
1. Alkaline balance 1st AM Ur 6.5-7.5
2. Antioxidants
Ascorbate 4-100g/d
3. Relaxation response Core/P TºF 1-1.1
4. Mucosal integrity
5. Dendritic
st
1
Trans Time 12-18º
responders Phagocytic Index
info: RussMD.Blog or 1.800.553.5472
Ascorbate needs vary widely
Physiology
st
1 …
Practice Guide
 In Practice:
Identify immune, toxin, neurohormone burden
 Substitute for reactive foods, medications:
[T cells, Immune Complexes & reactive Antibodies]
 Stimulate repair by evoking healing
 Restore tolerance, digestive & detox competences
 Achieve sustained remissions
 Personalized, better outcomes by design

 Address / redress causes (not consequences)
PERQUE Integrative Health, 1.800.525.7372
Physiology
st
1 …
Alkaline Way: PFAW
 Health & being well ‘Bhante effect’
 Immune defense & repair as ally or adversary
 Neuro-Immuno-Hormonal control system:
 Gain control of control systems!
 Health: balance, sufficiency & awareness
 Health equation = ‘builders’ - ‘depleters’
Jaffe R, Nash R, Ash R, Schwartz N, Corish R, Born T, Lazarus H. Healthcare transparency:
Opportunity or mirage. J Management Development 2006; 25 (10):981-995.
Bhante effect
The first 40 years,
I practiced the abuse of life,
since then,
the use of life….
which do you choose?
Sam Dech Preah Ven Bhante
V B Dharmawara Mahathera Mahatma
Decoded healing system
brought forward by Buddha
but lost >1,000 years ago.
Green light meditation
Green dichromatic light
Forest and plant green
Sihanook family advisor
Jarhalal Lal Nehru’s doc
Dhalai Lama’s mentor
Ven Bhante V B Dharmawara Mahathera Mahatma
Sam Dech Preah
Bhante at 109
7 years after full
recovery
from stroke
1887 or 1889 - 1999
Ukiah, CA 1996
st
1 …
Physiology
Alkaline Way: PFAW
 Immune defense & repair system
as ally rather than adversary

Mindbody amplifies perception

Can recondition responses

Practice relaxation response
or active meditation
Active Meditation The Western Tradition by Robert Leichtman, MD,
Ariel Press, 1976
Health is matter of balance: PFAW
Live in harmony with our nature…

Know our nature by practice

Honest communion from nature

Outcome studies test hypothesis:
Fibromyalgia CFIDS: p <0.01
Diabetes: p < 0.001 [HgbA1c, G/I]
Adrenal: p < 0.005 [Cort/DHEA]
www.BetterLabTestsNow.com: PFAW
 Free hormone measurement [Pl or Sa]
 Cortisol / DHEA rhythm
 Adrenaline / Serotonin balance
 FT3, FT4, & TSH
 Functional protocols (Self Tests)
 Ascorbate calibration
 1st AM Urine pH
 Transit time, dehydration test…
Physiology
st
1 …
Alkaline Way: PFAW
If we are not for ourselves,
Who will be for us?
If we are only for ourselves,
What are we?
If not now,
When?
Hillel, 1st century
From sceptic to practitioner:
Rediscovery of Physiology First
The Alkaline Way to restore enhance
or protect health
Russell Jaffe, MD, Ph.D., CCN, NACB
FASCP, FACN, FACAAI, FAMLI, FOCIS, FRCM
Fellow, Health Studies Collegium
Director, ELISA/ACT Biotechnologies, LLC.
Director, PERQUE, LLC.
Clinical protocols at www.PERQUE.com/protocols:
1. D-penicillamine provocation 4 essential & toxic minerals
st
2. 1 AM Urine pH assessment for metabolic acidosis
3. Digestive Transit Time measurement
4. Skin pinch hydration assessment
5. LRA by ELISA/ACT in practice
6. Ascorbate calibration protocol to counter oxidative stress
7. Food effects on body chemistry table
8. PERQUE Whey Guard for healthy weight management
9. Assessing zinc need by taste