Transcript Metabolic Pathways - University of California, Santa Barbara

Metabolic Pathways
Chapter 26
Metabolic Pathways – Ch. 26
1. List three reasons why the hydrolysis of ATP into
ADP and phosphate is so thermodynamically
favorable:
Metabolic Pathways – Ch. 26
2. Why is the rate of nucleophilic attack on ATP (ex
hydrolysis) significantly faster in an enzyme?
Metabolic Pathways – Ch. 26
3. An enzyme that catalyzes phosphorylation is called a
_______________. Compare and contrast the 3 possible
mechanisms for phosphorylation of a fatty acid in
order to attach it to coenzyme A.
Metabolic Pathways – Ch. 26
4. List and describe the four stages of catabolism:
Metabolic Pathways – Ch. 26
Metabolic Pathways – Ch. 26
5. For every one molecule of glucose that undergoes
glycolysis__________ molecules of pyruvate, __________
ATP molecules and ____________ NADH.
Metabolic Pathways – Ch. 26
6. What causes lactic acid build up?
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7. Before pyruvate can enter the citric acid cycle it must
be converted to _________________ by 3 enzymes and
the 5 coenzymes ___________,
______________,_____________,_____________ and
_______________ in the pyruvate dehydrogenase system
Metabolic Pathways – Ch. 26
8. In the first step of catabolism; fats are hydrolyzed
into ____________ and ______________. Catabolism of 1
molecule of palmitic acid (fatty acid with 16 carbons)
produces ___________ acetyl CoA
molecules______________ FADH2 molecules and
___________ NADH molecules.
Metabolic Pathways – Ch. 26
Metabolic Pathways – Ch. 26
9. The overall reaction for the citric acid cycle is
______________________________________ which produces
______________ molecules of
ATP________________molecules of NADH and
_________________molecules of FADH2 for every
molecule of acetyl CoA.
Metabolic Pathways – Ch. 26
10. Stage 4 of catabolism is _________________________ in which 1
molecule of NADH produces ___________ molecules of ATP and
1 molecule of FADH2 produces ____________ molecules of ATP.
Therefore for each molecule of acetyl CoA that enters the
citric acid cycle ____________ molecules of ATP are produced.
For every 1 molecule of glucose that is catabolized ___________
molecules of ATP are produced.
For every 1 molecule of palmitic acid that is catabolized_______
molecules of ATP are produced.
Metabolic Pathways – Ch. 26
11. What is the majority type of reactions in the
anabolic pathways?