Transcript Pancreas - School of Medicine, The University of Texas

Robert Scranton ©2008
Ventral buds of the
Dorsal & ________
 Develops from _______
duodenum
Process and a
 The Ventral portion becomes the Uncinate
_____________
Head
portion of the ______.
amylase & lipase
 The enzymes ________
______ appear around age 2.
compound acinar gland.
 Classified as a serous,
_______________________
AKA interlobular
Partially lined by
centroacinar cells
 Both centroacinar and intercalted duct cells secrete a
bicarbonate to ______________________.
neutralize stomach acid
substance containing ___________
 Both are stimulated by the hormone _________
secretin from the
enteroendocrine
tract mucosa
________________ cells of the GI
________________.
 Why make bicarb in the first place?
The stomach acid needs to be neutralized to optimize the
activity of pancreatic digestive enzymes
 Remember that the lining they form is incomplete.
 Describe their appearance.
Short cuboidal w/ clear cytoplasm
Centroacinar and Acinar Cells
 Synthesize and secrete (exocytosis) many digestive proenzymes.
 Must be in an alkaline
_______ environment to function.
 Two stimuli:
CCK
Vagal (parasympathetic) innervation
 Appearance and Arrangement
Pyramidally shaped, basophilic (more so on the ________
basal side
b/c of the RER
_____)
granules on the
 Major proenzymes (4), all packaged in Zymogen
________________
Golgi apparatus
apical side by the ______________
Protease- proteins
Lipase- lipids
Amylase- carbs
Ribonuclease & deoxyribonuclease- nucleic acids
Outline the Acini
Intercalated
Duct
Intralobular
Duct
Remember the
big picture.
Interlobular
Duct
Pancreatic
Duct
Intercalated
Duct
Intralobular
Duct
Interlobular
Duct
Pancreatic
Duct
Intercalated
Duct
Intralobular
Duct
Interlobular
Duct
Pancreatic
Duct
Intercalated
Duct
Intralobular
Duct
Interlobular
Duct
Pancreatic
Duct
 Acute pancreatitis (inflammation)- result of
 Biliary tract disease
 Alcoholism
 Pancreas digests itself from within, loss of function not apparent
60-80% loss.
until _______
Lipase measurable in blood.
Amylase & _______
 _________
Pancreatitis
 Islet of Langerhans usually spared until Chronic
__________________
fatal
rare but is typically _____.
 Pancreatic carcinoma is _____
Epitheloid cells AKA islets of ___________.
Langerhans
 Made of islands of ______________
tail of the pancreas and composed
 Most islets are found in the ____
of 4 cell types secreting 4 different things.
BAD I
G
S
 Zollinger-Ellison syndrome
 Where pancreas secretes gastrin stimulating gastric hypersecretion
and peptic ulceration
 Etiology- islet tumor/ gastrinoma
 IDDM and NIDDM- make sure you read over these diseases,
though this will more than likely be focused on in courses other
than microanatomy.
α Always stimulates
 Increases hepatic synthesis and storage of glycogen
 Increases transport of glucose into muscle
 Promotes triglyceride storage in fat
 Secretion stimulated by glucose
This year’s Presidental Lecture featured Dr. Kahn who
focused on insulin. Watch it here if you have a chance
after exams, I promise it is worth your time.
 Stimulates use of glycogen
 Gluconeogenesis in liver
 Inhibited by glucose (feedback mechanism)
 Inhibits insulin, glucagon
and digestive function
 unknown