Transcript File

Sylvia Assiamah
Temi Doyin
Shanakay Haughton
Kimberly Jenkins
Viven Walker-Marable
Pritika Prasad
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Name:
Medihoney
Classification: Antibacterial
Pharmacodynamics:
Antibacterial Action
Odor Reduction
Debriding
Anti-Inflammatory Effect
(Robson, Dodd, and Thamas, 2009)
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Broad spectrum antibacterial activity r/t high
sugar content and low water content
Heat stable antibacterial component, known as
methylglyoxal (MGO)
Formed from dihydroxyacetone, typically
found in the nectar of manuka flowers
(Robson, Dodd, and Thamas, 2009)
Reduction in odor is due
to inhibition of anaerobic
bacteria that are able to
ferment amino acids to
malodorous organic
amines
(Robson, Dodd, and Thamas, 2009)
Osmotic action of honey
encourages lymph fluid to
rehydrate devitalized tissue,
helping to remove slough and
necrotic tissue by moving fluid
away from the wound bed.
(Robson, Dodd, and Thamas, 2009)
Low pH, which help to
decrease protease
activity in the wound
thus decrease
Inflammation
(Robson, Dodd, and Thamas, 2009)
Used for light to moderately exuding wounds
such as: diabetic foot ulcers, leg ulcers (venous
stasis ulcers, arterial ulcers and leg ulcers of
mixed etiology), pressure ulcers/sores (partialand full-thickness), first- and second-degree
partial-thickness burns, donor sites, and traumatic
or surgical wounds
("Medihoney,”)
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Medihoney paste, the
most commonly used
medihoney product can
be used for hard-todress wounds and other
wounds normally
requiring gel or paste
Maintains the
effectiveness of wound
treatment even in the
presence of wound
fluid, blood and tissue.
("Medihoney,”)
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Advantageous to wound healing
High osmolality concentration
Provides cleaning and debridement action for
wound base
Quickly progresses to healing time
Quickens wound healing time even for
wounds with stalled healing
("Medihoney,”)
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(Active Leptospermum
Honey content – 63%)
Absorbs 2.5x the
amount of fluid of
leading hydrocolloids
Cooling and soothing
upon application
Two versions: Adhesive
and non-adhesive
For dry to moderately
exuding superficial to
partial thickness
wounds
("Medihoney,”)
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80% Active
Leptospermum Honey
and 20% Natural
gelling agents
Optimal for partial to
full thickness wounds
More viscous
formulation with
increased stability at
the wound site
("Medihoney,”)
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Paste
100% Active
Leptospermum
Honey
For dry to lightly
exuding wounds, or
for hard to dress areas
("Medihoney,”)
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Dressing
Adhesive and NonAdhesive
("Medihoney,”)
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Calcium Alginate
Dressing
For moderate to
heavy exuding
wounds
("Medihoney,”)
Despite its natural and nontoxic components, there are
some contraindication to using
Medihoney. This include
allergies to:
1.
Honey or alginic acid
2.
Plant pollen
3.
Bee sting venom
("Medihoney top”)
1. Known hypersensitivity to, or intolerance of,
honey;
2. Current or recent (within 4 weeks) treatment
with an antibiotic administered by any route; and
3. Nasal carriage of mupirocin-resistant S. aureus.
4. Diabetes
5. Wounds with suspected malignancy
("Medihoney top”)
A 79-year-old male paraplegic (Th4) patient with
sacral ulcer grade 3.
(a) First photo documentation.
(b) Second photo, 2 weeks after Medihoney
treatment.
(c) Third photo, 4 weeks use of medihoney as a
non-surgical therapy for chronic pressure
ulcers in patients with spinal cord injury
(Adapted from “Use of medihoney as a non-surgical therapy for chronic pressure ulcers
in patients with spinal cord injury by Biglari et al., 2012)
A 35-year-old male paraplegic (Th1)patient with
ischial and scrotal ulcer grade 3–4 .
(a) First photo documentation.
(b) Second photo, after primary surgical
debridement and 2-week Medihoney
treatment.
(c) Third photo, 4 weeks after Medihoney
treatment. Use of medihoney as a non-surgical
therapy for chronic pressure ulcers in patients
with spinal cord injury
(Adapted from “Use of medihoney as a non-surgical therapy for chronic pressure ulcers
in patients with spinal cord injury by Biglari et al., 2012)
A 51-year-old male paraplegic (L1) patient with ankle
ulcer grade 3 with Methicillin-resistant
Staphylococcusaureus.
(a) First photo documentation.
(b) Second photo, 2 weeks after Medihoney treatment.
(c) Third photo, 4 weeks after Medihoney treatment,
with eradication of Methicillin-resistant
Staphylococcus aureus.
(Adapted from “Use of medihoney as a non-surgical therapy for chronic pressure ulcers in
patients with spinal cord injury by Biglari et al., 2012)
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Imperative to monitor the progress of wounds
Wound not responsive after 14 days of
treatment
Wound is malodorous
Signs of further breakdown
No precautionary are required for diabetics
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Used for centuries across the world in the
treatment and management of wounds
Used to accelerate the healing of infected slow
healing wounds
Accelerated process is linked to its organic
composition and its antibacterial properties
In 2007 after numerous trails, in all age groups,
the US Food and Drug Administration (FDA)
approved its use in market for treatment in
honey-based wounds
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Laboratory studies support honey having
antibacterial properties and have been effective
against broad spectrum pathogens preventing
treatment resistance as seen in antibiotics use.
As a result of this action the wound pH change to
acidic which in turn stimulate the activation of
phagocytes leading to a decrease bacterial growth
Medihoney products that go directly in the wound
accelerate healing by: promoting a moist wound
environment, thus making it easy for necrotic
tissue to slough off and debridement to occur.
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Honey had a mean 67%
reduction of slough
New epithelial tissue
was visible 15 days
earlier in honey than
other dressing products
Dressing has proven to
be safe, low cost and
effective in the
treatment for nonresponsive wounds in
all age groups
Action of honey
1. Bringing about clearance of infection in
wounds
2. Accelerating healing through activation of
autolytic debridement
3. Anti-inflammatory activity
4. Antioxidant activity
5. Stimulation of growth of cells for tissue repair,
6. An osmotic action.
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Prepared by application of the honey to a nonadherent sterile contact layer that was placed
on top of a sterile dressing pad
Honey applied at a thickness of approximately
3 mm and conformed to the shape of the ulcers
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There is no cultural
consideration
Participants of any
age with an acute or
chronic wound
No limitation on
ethnicity
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'peppery' or stinging
sensation when
Medihoney is applied
to wound
Symptoms secondary
to honey exposure
Diarrhea
Vomiting
Bloating
Cramping
Abdominal Pain
Biglari, B., Vd Linden, P.H., Simon, A., Aytac, S., Gerner, H. J., &
Moghaddam, A. (2012). Use of medihoney as a non-surgical
therapy for chronic pressure ulcers in patients with spinal
cord injury. Spinal Cord, 50(2), 165-9.
Cooper, G. (2011). Medihoney dressing made easy. Wounds, 6(2):
1-6
George, N.M. & Cutting K.(2007). Antibacterial Honey
(Medihoney): In-vitro Activity Against Clinical Isolates
of MRSA, VRE, and other Multiresistant Gram-negative
Organisms Including Pseudomonas. Wounds, 19(9), 231236.
Grothier, L., & Cooper, R. (2011). Medihoney Dressing made
easy products for practice. Wounds UK, 6(2), 1-6. Retrieved
from http://www.wounds-uk.com/made
easy/medihoney-dressing-made-easy---products-forpractice
Medihoney top. (n.d.). Retrieved from
http://www.webmd.com/drugs/drug-163032. Medihoney
Top.aspx?drugid=163032&
Medihoney. (n.d.). Retrieved from
http://www.dermasciences.com/products/advanced-woundcare/medihoney/inside-the-u-s/\
Mustafa, F., Nguyen, T., & Lim, L. (2007). Honeybee venom
secretory phosholipase A2 induces leukotriene production but
not histamine release from human basophils. Clinical and
Experimental Immunology, 151: 94-100.
Pieper, B. (2009, January). Honey-based dressings and wound care: An
option for care in the United States. J WOCN, 60-66.
Robson, V., Dodd, S., & Thomas, S. (2009).
Standardized antibacterial honey
(Medihoney™) with standard therapy in
wound care: randomized clinical trial.Journal
of advanced nursing, 65(3), 565-575.
Simon, A., Traynor, K., Santos, K., Blaser, G.,
Bode, U., & Molan, P. (2009). Medical honey
for wound care – still the ‘latest resort’?.
Advance Access Publication, 6(2): 165-173.
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What is the most commonly used medi honey
product? Medihoney Paste
True/False Medihoney reduce inflammation
in wounds. True
True /False Medihoney have antibiotic
properties that promote wound healing. True
Honey has antibacterial action against range of
bacteria except the growth of which
organisms? S. Marcescens and C. Albicans
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Medihoney is used for which type of wounds
select all that apply? All of the above
1. Diabetic Ulcer
2. Venous Statis Leg Ulcers
3. Arterial Leg Ulcers
4. Pressure Ulcers (all 4 stages)