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Transcellular transport of digoxin (a), ochratoxin A (b), olmesartan (c), and ES (d) and
permeation of mannitol and LY (e) across Caco-2 cells and TEER (f) during culturing days. □,
Papp, A to B of digoxin, ochratoxin A, olmesartan, and ES; , Papp, B to A of digoxin, ochratoxin
A, olmesartan, and ES; •, Papp, A to B of mannitol; ▴, Papp, A to B of LY; ♦, Papp ratio with 95%
confidence interval; ▪, TEER. Each Papp and TEER represent the mean + S.D. of three
experiments.
Emi Kamiyama et al. Drug Metab Dispos 2009;37:1956-1962
The American Society for Pharmacology and Experimental Therapeutics