Transcript Lesson 1-Introduction Lecture unit1Lesson1x

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 What are some different categories of biological
molecules?Proteins, lipids, DNA, carbohydrates
 Drugs come from a variety of sources, some plant-based,
others synthetic, and still others from animal-based
sources. Can you name two drugs from each category?
Answers will vary here
 Can you define drug abuse? What about addiction?Using
a drug inappropriately, not being able to function w/o
drug?
 Public opinion about drugs changes constantly. Can you
describe a drug and for that drug, describe how the
thinking about its importance or the danger has changed
from the past until today? Maijuana?
 What are some public service announcements you’ve
heard aimed at preventing drug abuse? Answers vary
This is a recent Washington state drug
related budget:
A
Education
Which slice do you
think represents
Education?
B
C
D
Policy &
enforcement
Treatment
This is a
brain on
drugs
Societal “Bandaids”
Neuroskeptic.blogspot.com
Ms. Walter
[email protected]
Unless they are
needed for the
lesson
1.
2.
3.
4.
5.
6.
Don’t do drugs!
If it feels good, do it!
Just say no.
Everything in moderation.
Street drugs are bad, medical drugs are OK.
The more evidence you have about drugs and the
way they work in your brain, the better decisions
you can make
What are the qualifications of the person who
is answering these teens’ questions?
What experiences do these teens describe that
indicate drug use affects them?
What does this video suggest about ways
scientists can measure how a drug impacts the
brain?
Why do some drugs make us feel pleasure and
why do we have a pleasure center in the brain
in the first place?
Dr. Nora Volkow
Didade.com
A drug =
Any substance taken in to the body which alters the
function or physiology of the body in a way that is
NOT nutritional.
1. Yes
2. No
3. Not sure
4. Depends on why
you use it
“Snake Oil Salesman”
in the past, right?
Imagine your company is making a new
drug to treat ADHD.
How do you test its effectiveness? What
would you do? Brainstorm w/group.
47 studies
>5000 patients
4 drugs
What is this
graph telling
you?
Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria
A, Moore TJ, et al. PLoS Medicine Vol. 5, No. 2,
pmid.0050045
Yes?
No?
 Addiction: physical
change and development
of tolerance and
withdrawal syndrome.
 Drug Dependence: may
be physical or
psychological:
withdrawal and tolerance
are not necessarily seen:
applicable to any drug
situation.
 Commons.wikimedia.org/
wiki/files:psychoactive_dr
ugs.jpeg
 Behavioral pattern of
compulsive use: extreme
on a continuum of drug
involvement (p.9, Liska):
high tendency to relapse.
From my generation:
• The Rolling Stones
• Pink Floyd
• KISS
• John Belushi
More recently:
• Philip Seymour Hoffman
• Whitney Houston
• Amy Winehouse
Normal interaction of ligands with cell membranes
Graphic designer Conn McQuinn
Normal ligand plus drug-what kind of interaction do you see?
Graphic designer Conn McQuinn
How is this different? What new interaction do you see?
Graphic designer Conn McQuinn
1. Protagonist
2. Agonist
3. Partial Agonist
4. Antagonist
5. I’m not sure
1. Protagonist
2. Agonist
3. Partial Agonist
4. Antagonist
5. I’m not sure
Capsnet.usc.edu
artritis.about.com
Neurobiology
Pharmacology
Genetics
Stimulants
Getsmartaboutdrugs.com
Depressants
Psychedelics
[email protected]
feiradocanhamo.hi5.com