Transcript 999 Deaths - Indiana Pharmacists Alliance

Combating the Opioid Abuse Epidemic
with Evzio® (naloxone)
Baely Crockett, PharmD
Eskenazi Health Internal Medicine PGY2
This speaker has no actual or potential conflicts of interest to disclose in relation to this presentation.
43,982 Drug Overdose Deaths in 2013
NonPrescription
21,215
Prescription
22,767
Opioid
16,235
Other
6,532
Centers for Disease Control and Prevention. CDC’s top ten: 5 health threats in 2014.
Centers for Disease Control and Prevention. Injury prevention & control: prescription drug overdose.
Drug Overdose Deaths in Indiana
999 Deaths
206 Opioids
690
Other
unspecified
drugs
Indiana State Department of Health. Special emphasis report: drug overdose deaths. 2014.
98 BZD
30 Cocaine
110
Heroin
Opioid Mechanism of Action and Abuse
University Of Florida. Opioids: mechanism of action.
Treatment of Opioid Overdose
Naloxone and overdose prevention education program of Rhode Island.
Naloxone
• Routes of administration
• Intravenously
• Intramuscularly
• Subcutaneously
• Intranasally
• Nebulizer
Naloxone. LexiComp. 2015
Kaleo, Evzio. 2015.
What is Evzio®?
• Hand-held, single-use naloxone auto-injector
• Intramuscularly or subcutaneously
• Outer thigh
• Holds 0.4 mg of naloxone
• User-friendly with audio instruction on appropriate
administration
• Does not replace need for emergency medical
assistance
Kaleo, Evzio. 2015.
Audience Participation
Who can administer Evzio?
A. Patients prescribed high doses of opiates
B. Family members of patients who are
prescribed high doses of opiates
C. Health care professionals working at a pain
management clinic
D. All of the above
Kaleo, Evzio. 2015.
How to use Evzio®
1. Remove cap
2. If ready to use, pull off
red safety guard
3. To inject, place black
end against outer
thigh then press firmly
and hold in place for
five seconds
4. Counts down from five
to one
Kaleo, Evzio. 2015.
How to use Evzio®
(cont’d)
5. Injection complete
6. Seek emergency
medical attention
7. This device has been
used and should be
taken to your physician
for proper disposal and
a prescription refill
Kaleo, Evzio. 2015.
Increased Access to Naloxone
Pros
Frontline personnel
would be able to treat
patients faster to save
lives
Kaleo, Evzio. 2015.
Cons
Abusers may try higher
doses, knowing reversal is
at their fingertips
Combating the Opioid Abuse Epidemic
with Evzio® (naloxone)
Baely Crockett, PharmD
Eskenazi Health Internal Medicine PGY2
This speaker has no actual or potential conflicts of interest to disclose in relation to this presentation