Transcript DMDG PK Course 2010x

NEW PHARMACOKINETICS WORKSHOP
AN INTEGRATED APPROACH TO PRECLINICAL PHARMACOKINETICS
FANHAMS HALL, WARE
Synopsis
The course takes the format of a series of lectures detailing theory and
practice where the content is reinforced by the conduct of tutorials in small
break out groups to create a forum for discussion and further learning.
Delegates will be expected to play an active role in data calculation,
interpretation and discussion.
The objectives for the DMDG course on Pharmacokinetics in Drug Discovery
are to develop an understanding and appreciation of the importance and
contribution of drug metabolism and pharmacokinetics to drug design by
first intent. The course highlights the importance of physicochemical
properties in drug design and covers the fundamental aspects of
pharmacokinetics and pharmacodynamics, safety study design and
toxicokinetics, the importance of ADME and the relevance of metabolite
pharmacokinetics.
Approaches to the prediction of human pharmacokinetics and dose are
introduced and concepts associated with the assessment of
pharmacokinetics in First Time in Human and Proof of Concept clinical trials
are discussed.
The overarching theme is one of data integration and the utility of
pharmacokinetic evaluation to assess and contextualise risk vs benefit at
key stages of drug discovery and development. To illustrate the utility of
DMPK science in the pharmaceutical industry in relation to compound
progression the delegates also have the opportunity to conduct a series of
workshops and integrate data from numerous sources to overcome real life
problems and decisions in preclinical drug discovery and development.
The Programme
Day 1
Introduction
Basic Pharmacokinetics
Basic Pharmacokinetics tutorial
Day 2
Physicochemistry
Pharmacokinetics in Drug Discovery
Pharmacodynamics
Pharmacodynamics Tutorial
Toxicokinetics
Toxicokinetics Tutorial
Workshop. Lead selection.
Day 3
ADME in Drug Development
Metabolite Pharmacokinetics
Workshop. Candidate selection.
Predicting Pharmacokinetics in Man
Pharmacokinetics of Biologics
Workshop. To the Clinic.
Current course tutors
come from the companies below
Day 4
Workshop Conclusions
Clinical Pharmacokinetics
Photos courtesy of Shane Hewitt