Transcript Intro to AAPS - American Association of Pharmaceutical Scientists

Intro to AAPS
for students,
student chapters,
prospect members
Tuesday, October 6. 2015
Introduction
Presenters:

Shraddha Thakkar, BIOTEC

Rachel Saylor, DDDI

Katie Maass, SPOD

Manjeet Pimparade, FDD

Vibhuti Agrakari, SPOD

Yamini Gorantla, MSE

Paddy Eangoor, APQ

Sophia Fong, PPB

Tanzir Mortuza, BIOTEC

Nicole Zane, PPDM

Amelia Deitchman, CPTR

Anqi Wan, RS

Johannes Kast, CPTR
AAPS Mission and Vision
Mission
AAPS advances the capacity of pharmaceutical scientists to
develop products and therapies that improve global health.
Vision
AAPS will advance the pharmaceutical sciences to drive
prevention and cures.
Core Values

Learning

Innovation

Service

Inclusiveness

Integrity
AAPS Students and Postdoc
Membership
Student/PostDoc Membership comprise
25% of all AAPS Membership
2225
6303
Regular Members
Student/Postdoc Members

1,825
Student
Members

401
Postdoc
Members
Over 100 AAPS Student
Chapters across the world
Webinar Overview
AAPS provides robust networking
community and countless opportunities:

AAPS Sections

Focus Groups

Education and Resources

Student/Postdoc Outreach Committee

Career Center
Introduction
to AAPS
Sections &
Focus Groups
AAPS Sections

Groups with interests in broad areas of
pharmaceutical sciences.
 Responsibility
for governance
 Broad
in scientific scope,
 Share
research
 Serve
on AAPS committees
 Participate
in meetings and workshops
Section Offerings for
students

AAPS Mentoring

Travelships

Awards

Moderating Opportunities
AAPS Sections

APQ —Analysis and Pharmaceutical
Quality section

BIOTEC — Biotechnology section

CPTR — Clinical Pharmacology and
Translational Research section
AAPS Sections

DDDI — Drug Discovery and
Development Interface section

FDD — Formulation Design and
Development section

MSE — Manufacturing Science and
Engineering section
AAPS Sections

PPB — Physical Pharmacy and
Biopharmaceutics section

PPDM — Pharmacokinetics,
Pharmacodynamics, and Drug
Metabolism section

RS — Regulatory Sciences section
AAPS Student Membership
STUDENTS ON AAPS SECTIONS
PPDM
13%
RS
3%
APQ
5%
BIOTEC
10%
CPTR
10%
PPB
11%
MSE
5%
DDDI
11%
FDD
32%
AAPS Focus Group
Within each section are multiple focus groups
(FG)
 There are over 40 focus groups
 FG can be shared by multiple sections
 Collaboration opportunities
 Networking opportunities

DDDI 
Primary FG: Discovery Model & Simulation
 Other affiliated sections: PPDM, PPB
APQ
PRESENTER: PADMANABHAN (PADDY) EANGOOR,
MERCER UNIVERSITY
APQ—Analysis and
Pharmaceutical Quality section
Goals: Provide a forum for the exchange of information
pertaining to analytical techniques, bioanalytical techniques,
regulatory and compendial issues, and assurance of quality
Leadership:

Chair: Peter D. Bryan, Ph.D.

Chair-elect: Dilip R. Choudhury, Ph.D.

Vice-chair: Eliza Fung, Ph.D.

Secretary/Treasurer: Mark E. Arnold, Ph.D.

Past chair: Kenneth Jay Norris, M.S.
Members: 2159
Student members: 208
Student representative: Paddy Eangoor (Mercer University)
Paddy’s recent blog post: Turning Point of a Graduate Student
APQ—Analysis and Pharmaceutical
Quality section
Primary focus groups
Secondary focus groups

Bioanalytical


Contract Research
Organization (CRO)
Chemical and Biological Active
Pharmaceutical Ingredient
Manufacturing Technology

Biosimilars

Chemistry, Manufacturing, and
Controls (CMC)

CMC Statistics

Generic Pharmaceuticals

Ligand Binding Assay
Bioanalytical

Microdialysis

Nutraceuticals and Natural
Products

Process Analytical Technology

In Vitro Release and Dissolution
Testing

Non-clinical Dose Formulation
and Analysis

Pharmaceutical Impurities

Stability
APQ—Analysis and
Pharmaceutical Quality section
Opportunities:
Mentoring program
 Student travelships to attend annual meeting
 Awards at the Annual meeting


AAPS APQ Best Poster Award

AAPS Graduate Student Research Awards in Analysis
and Pharmaceutical Quality

AAPS Outstanding Manuscript Award in Analysis and
Pharmaceutical Quality

APQ Research Achievement Award
APQ—Analysis and
Pharmaceutical Quality section
More opportunities

Webinars and interviews with thought leaders of APQ
section

APQ newsletter: Volunteers can contribute

AAPS APQ Education initiation award

Planning for a robust APQ Student Section Committee


Seeking volunteers to serve on the committee
Volunteer opportunities in affiliated focus groups
For more information about APQ section, please visit:
https://www.aaps.org/APQ/
BIOTEC
PRESENTER: TANZIR MORTUZA, UNIVERSITY OF
GEORGIA
BIOTEC—Biotechnology
Section
Vision: Unite multiple scientific disciplines in a
forum where experimental results and
experiences are shared and evolving
concerns on the research, development, and
manufacture of biotechnology based
pharmaceuticals are discussed
BIOTEC—Biotechnology
Section
BIOTEC Leadership –

Chair - Gopi Shankar, Ph.D., MBA

Chair-elect - Meena Subramanyam, Ph.D.

Vice Chair - Scott Fountain, Ph.D.

Secretary/Treasurer - Boris Gorovits, Ph.D.

Past Chair - Tapan K. Das, Ph.D.
BIOTEC—Biotechnology
Section
Current Student Committee (BSSC)

Chair – Tanzir Mortuza (University of Georgia)

Secretary – Katherine Hickey (West Virginia
University)

NBC Liaison – Fizal Nabbie (University of Science
Philadelphia)

Student Rep – Hardik Mody (Ohio State
University)
BIOTEC—Biotechnology
section
Opportunities for students


Mentor and Mentee opportunity

25 matches

Matches were based on interests and geographical locations
Student Rep opportunity

For primary and secondary focus group

Placed student rep for Ligand Binding Assay Bioanalytical FG
(LBABFG)
Student Professional Development Webinar – April 15th, 2015
The Do’s and Don’ts that Define Success for Academic Job
Applications


Speakers – Dr. Christopher McCurdy (University of Mississippi) & Dr.
Brian Cummings (University of Georgia)
BIOTEC—Biotechnology
section
More Opportunities
 Awards and Travelships – Travelships up to
$750 (graduate/undergraduate students,
postdocs eligible)
 AAPS Graduate Student Research - Award in
Biotechnology sponsored by Janssen
 Newsletter/ Blog contribution
 BIOTEC Section Townhall Meeting and
Reception at 2015 Annual Meeting
BIOTEC—Biotechnology
section
Future Goals:

1 more Webinar before end of the year

2 Student Development Webinars for year 20152016

Increase student participation in BIOTEC

25 Co-moderator placement at Annual Meeting

Initiate mentor-mentee interactions
BIOTEC—Biotechnology
section
Primary Focus Groups

Biosimilars

Ligand Binding Assay Bioanalytical

Protein Aggregation and Biological
Consequences

Therapeutic Product Immunogenicity
For more information about APQ section, please visit:
http://www.aaps.org/BIOTEC/
CPTR
PRESENTER: AMELIA DEITCHMAN & JOHANNES KAST,
UNIVERSITY OF FLORIDA
CPTR—Clinical Pharmacology and
Translational Research section
Vision
“The AAPS CPTR section is dedicated to clinical and translational
research and development of human pharmaceutical products,
particularly related to issues of clinical pharmacology or applied
pharmacotherapy (including adverse drug reactions and special
populations), clinical pharmacokinetics and pharmacodynamics,
clinical trial design and simulation, pharmacogenomics, and
contract research of human pharmaceuticals. The scope of the CPTR
section extends beyond the development of human
pharmaceuticals into the postmarketing phase and ultimately the
clinical performance of medicines administered to patients.”
CPTR—Clinical Pharmacology and
Translational Research section
Leadership

Chair: Alexander Vinks, PharmD, PhD, FCP (Cincinnati's
Children’s Hosipital)

Chair-elect: Arnab Mukherjee, PhD (Pfizer)

Vice Chair: Adel H. Karara, PhD, FCP (U Maryland Eastern
Shore)

Secretary/Treasurer: John D. Davis, PhD (Regeneron)

Past Chair: Joan M. Korth-Bradley, PharmD, PhD (Pfizer)
Student Representatives:

Amelia Deitchman, PharmD (University of Florida)

Johannes Kast, RPh (University of Florida)
CPTR—Clinical Pharmacology and
Translational Research section
Opportunities for Students

Mentoring Program (mentors from across the
pharmaceutical industry, regulatory, and academic
settings)

Student Travelships & Awards

AAPS Graduate Student Research Awards in PPDM & CPTR
(Sponsored by Eli Lilly)
CPTR—Clinical Pharmacology and
Translational Research section
Focus Groups
Primary
Secondary

Biomarkers in
Translational Medicine

Animal Pharmaceutics &
Technology

Pharmaceuticals in
Global Health

Drug Transport

Pharmaco-imaging

Microdialysis

Pharmacogenomics
(PGx)

Protein Aggregation and
Biological Consequences

Pharmacometrics


Systems Pharmacology
Therapeutic Product
Immunogenicity
For more information visit: http://www.aaps.org/CPTR/
DDDI
PRESENTER: BRITTANY DUERK SPITZNAGEL, LIPSCOMB
UNIVERSITY
DDDI—Drug Discovery and
Development Interface section
Goal: DDDI focuses on issues at the critical interface between drug
discovery and drug development and provides a collaborative
forum for interactions among scientists from academia, industry and
government institutions.
Leadership:

Chair: Susan L. Mercer, Ph.D.

Chair-elect: Robin M. Zavod, Ph.D.

Vice Chair: Caroline McGregor, PhD

Secretary/Treasurer: David A. Colby, Pharm.D., Ph.D.
Student Rep: Rachel Saylor (University of Kansas)
DDDI—Drug Discovery and
Development Interface section
Focus Groups
Primary

Discovery Modeling
and Simulation

Drug Candidate
Selection

Nutraceuticals &
Natural Products
Secondary

Drug Metabolism

Drug Transport

Nanotechnology

Oral Absorption

Pharmaco-imaging

Pharmacogenomics
(PGx)

Targeted Drug Delivery
and Prodrug
DDDI—Drug Discovery and
Development Interface section
Opportunities for students
 DDDI
Mentoring Program
 Awards/Travelships
 DDDI
newsletter and eBlast
 Planning
for a DDDI Student Section Committee
 Volunteer
opportunities in affiliated focus groups
For more information visit: http://www.aaps.org/DDDI/
FDD
PRESENTER: MANJEET PIMPARADE, UNIVERSITY OF
MISSISSIPPI
FDD—Formulation Design and
Development section
Vision: The Formulation Design and Development section will be
the premier worldwide forum for scientists dedicated to the design
and development of all dosage forms for drugs, biologics, and
combinations thereof as well as drug/biologic device
combinations.
Leadership

Chair: Panayiotis P. Constantinides

Chair-elect: Joseph P. Reo

Vice-chair: Jeffrey Hemenway

Secretary/Treasurer: Linda A. Felton

Past-Chair: Michael A.Repka
Student Representative: Manjeet B.Pimparade (Ole Miss)
FDD—Formulation Design and
Development section
Opportunities for students

The FDD section benefits its members both personally and
professionally through various activities.

Awards/Fellows/Travelship

Communication

Education

Focus Groups

Volunteer Opportunities
FDD—Formulation Design and
Development section
Focus Groups
Primary
Secondary

Animal Pharmaceutics and
Technology

Dermatopharmaceutics

Excipients

Inhalation and Nasal Technology

Lipid-Based Drug Delivery Systems

Preformulation

Modified Release

Process Development

Ocular Drug Delivery & Disposition

Process Modeling and Simulation

Patient-Centric Drug Development,
Product Design, and Manufacturing


QbD and Product Performance

Sterile Products



In Vitro Release and Dissolution
Testing
Nanotechnology
Nutraceuticals and Natural
Products
Contract Research Organization
(CRO)
For more information visit: http://www.aaps.org/FDD/
MSE
PRESENTER: YAMINI GORANTLA, MERCER UNIVERSITY
MSE—Manufacturing Science and
Engineering section
Vision: The Manufacturing Science and Engineering section will be
recognized globally as the premier organization of individuals
dedicated to the advancement of science and engineering as
applied to the design and manufacture of investigational and
commercial pharmaceutical and pharmaceutically related
products.
Leadership:

Chair : Vidya Swaminathan

Chair-elect : Ruta Y. Waghmare

Vice Chair : Sharmista Chatterjee

Secretary/Treasurer: Claire Scanlan

Past Chair: Tom Sam
Student Representative: Yamini Gorantla (Mercer University)
MSE—Manufacturing Science and
Engineering section
Goals

Provide a forum for open interchange and dissemination of scientific
knowledge and technical advances related to manufacture of
pharmaceutical and pharmaceutically related products.

Provide timely programming, strong networking and membership
interactions, recognition of scientific achievement, and vigorous interorganizational collaboration.

Foster graduate education, career growth, and professional
development of the membership while promoting continued growth
and implementation of science and technology as applied to
manufacturing.

Collaborate with other AAPS sections, focus groups, and other
scientific organizations associated with the development, registration,
control, production, and troubleshooting of pharmaceutical products.

Recognize excellence and achievement of its members, encourage
programming and publication of manufacturing-related scientific
works by its members in AAPS-sponsored journals, and fosters graduate
education and career growth and development of MSE members.
MSE—Manufacturing Science and
Engineering section
Focus Groups
Primary

Chemical and biological
active pharmaceutical
ingredient
manufacturing
technology

Process Analytical
Technology

Process Development

Process modeling and
simulation
Secondary

Chemistry, Manufacturing
and Controls(CMC)

CMC Statistics

Modified Release

Patient-Centric Drug
Development , Product
Design, and
Manufacturing

Pharmaceutical Impurities

QbD and Product
Performance

Sterile Products
MSE—Manufacturing Science and
Engineering section
Opportunities for students:

5 Travel ships

2 Graduate student research achievement awards

Volunteer opportunities on various committees with in the section

Mentoring program

Ambassador Program

MSE newsletter

Networking

Discussions in AAPS Blog and Linkedin
(https://www.linkedin.com/groups/AAPS-Manufacturing-ScienceEngineering-MSE-3910244/about)
For more information visit: http://www.aaps.org/MSE/
PPB
PRESENTER: SOPHIA FONG, UNIVERSITY OF SOUTHERN
DENMARK
PPB Section—
Physical Pharmacy and Biopharmaceutics
Vision: recognized as the premiere global organization
for scientists
involved in physicochemical and
biopharmaceutic characterization and delivery of small
molecules and biologics.
Leadership:

Chair: Weiguo Dai (J&J)

Chair-Elect: Roy Haskell (BMS)

Vice Chair: Allen Templeton (Merck)

Secretary/Treasurer: Eric Munson (University of
Kentucky)

Past-Chair: Tycho Heimbach (Novartis)
Student representative: Sophia Y.K. Fong (University of
Southern Denmark)
PPB Section—
Physical Pharmacy and Biopharmaceutics
a Multidisciplinary Science
Material science
(polymorphs, forms,
salts), physical
stability and
chemical stability
Drug
Substance/Formulation
Solubility, pKa, etc.
amorphous/crystalline
Nanotech
Solubility
↑ Bile Salt
↑ In vivo solubility
↓ Precipitation Rate
Dissolution
Profile
Biorelevant
Solubility
Precipitatio
n
Time
GI physiology:
↑ Stomach pH
↑ Stomach emptying
Time
↓ Intestinal pH
↑ GI blood flow
Permeability:
Inhibition of Efflux or
Uptake Transporters
PBPK models
Fabs , F
Disposition PK
(CL, Vd)
Effective
Permeability
In vitro-In vivo
Scaling
Caco-2 or
MDCK Papp
GI transporter
Jmax, Km
PPB Section—
Physical Pharmacy and Biopharmaceutics
Focus Groups

Nanotechnology

Oral Absorption

Preformulation

Targeted Drug Delivery and Prodrugs
PPB Section—
Physical Pharmacy and Biopharmaceutics
Distribution of membership of PPB Section
Regular members
4.4%
Student members
Origins of PPB international student membership
4.37%
Number of PPB student members
95.6%
95.63%
43.3%
80
32.8%
60
40
11.7%
20
6.1%
6.1%
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PPB Section—
Physical Pharmacy and Biopharmaceutics
Opportunities for students:

Awards/Travelships

PPB mentorship program

Mentors from pharmaceutical industry, academia and regulatory bodies

PPB newsletter and eBlast

Student executive committee



Welcome student volunteers to join!
PPB Education Initiative

Funding for student chapters to invite renowned PPB scientists for 1-2 days event

International ($1,500), US ($1,000)
PPB Ambassador Program

encourage volunteers to visit local universities and utilize the presentation slide
deck to introduce AAPS and PPB Section
For more information visit: http://www.aaps.org/PPB/
PPDM
PRESENTER: NICOLE ZANE, UNIVERSITY OF NORTH
CAROLINA
PPDM- Pharmacokinetics
Pharmacodynamics Drug Metabolism
Vision: Dedicated to discovery, development, and manufacturing of
pharmaceutical products & therapies with focuses on the
biopharmaceutics, pharmacokinetics, pharmacodynamics,
metabolism, and transport of new and existing drugs.
Leadership:

Chair: Reina Bendayan

Chair-Elect: Pankaj Desai

Vice Chair: Maciej Zamek-Gliszcynski

Secretary/Treasurer: Shannon Dallas

Past- Chair: Douglas Sweet
Student Representatives:

Camille Alam (University of Toronto)

Hari Ananthula (University of Cincinnati)
PPDM- Pharmacokinetics
Pharmacodynamics Drug Metabolism
Specific research interests:

Transporters

Enzyme-mediated
metabolism

Preclinical pharmacokinetics

Microdialysis

Translating preclinical to
clinical

In vitro-in vivo extrapolation

Systems pharmacology
PPDM- Pharmacokinetics
Pharmacodynamics Drug Metabolism
Focus Groups
Primary

Drug Metabolism

Drug Transport

Microdialysis

Cellular and Molecular
Toxicology
Secondary

Animal Pharmaceutics and Techonology

Bioanalytical

Bioequivalence

Biomarkers in Translation medicine

Contract Research Organization (CRO)

Dermatopharmaceutics

Discovery Modeling and Simulation

Drug Candidate Selection

Non-clinical Dose Formulation and Analysis

Ocular Drug Delivery & Disposition

Oral Absorption

Pharmaco-imaging

Pharmacometrics

Systems Pharmacology

Targeted Drug Delivery and Prodrug
PPDM- Pharmacokinetics
Pharmacodynamics Drug Metabolism
Opportunities

Moderator Program


PPDM Education Initiative


Students moderate workshops at the annul meeting and national
biotechnology conference
Funds student chapters to invite prominent PPDM scientists to
travel to the chapter and teach about their research
Newsletter

Students encouraged to submit news and stories that are
distributed bi-annually to all members
For more information visit: http://www.aaps.org/PPDM/
RS
PRESENTER: ANQI WAN, UNIVERSITY OF ARKANSAS
FOR MEDICAL SCIENCES
RS—Regulatory Sciences section
Vision: To provide an international forum for advancing regulatory
sciences by proactively fostering the development and realization of
innovative, science-based regulatory solutions, which ensure the safety
and efficacy of drugs, biologics, devices, and combination products.
Leadership:

Chair: Nagesh Bandi, Ph.D (Pfizer)

Chair-Elect: Monica Le Whitmire, MS

Vice Chair: Lynn C.Gold, Ph.D.

Secretary/Treasurer: Edward A. Narke

Past-Chair: Thirunellai G Venkateshwaran, Ph.D.
Student representative: Anqi Wan (University of Arkansas for Medical
Sciences)
RS—Regulatory Sciences section
Defining features:




Unique environment exhibiting characteristics similar to
both academia and industry.
Protect public health by ensuring the safety and efficacy
of drugs.
Provide public with accurate, science-based information
on medications.
Empowers individuals with outstanding opportunities to
serve the public as members of a world-class, sciencebased Public Health Agency.
RS—Regulatory Sciences section
Focus Groups




Bioequivalence
Chemistry, Manufacturing and Controls (CMC)
CMC statistics
Generic Pharmaceuticals
RS—Regulatory Sciences section
Opportunities for students:

Awards/Travelships

Networking opportunities

Mentoring program


Mentors from pharmaceutical industry,
academia and regulatory bodies
RS newsletter
For more information visit: http://www.aaps.org/RS/
AAPS Student/Postdoc Outreach
Development Committee (SPOD)
Advocates and addresses issues of concern for students
and postdoctoral fellows in the pharmaceutical and
related sciences;
 Provides program funding
 Visiting Scientist Program
 Professional Development opportunities
 K – 12 STEAM outreach
SPOD Student Representatives:
 Vibhuti Agrahari (UMKC)
 Katie Maass (MIT)
For more information visit here.
AAPS Career Center and Services
Questions?
For more information about AAPS,
visit: www.aaps.org
Or email Mary Jo Bean at
[email protected]