Clonorchis Sinensis - Winona State University
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Transcript Clonorchis Sinensis - Winona State University
CLONORCHIS SINENSIS
Becky Koehler
Emma Lee Shaler
WHAT IS IT?
Human liver fluke
Found in bile duct and gall bladder
Feeds on the bile
Acquired by eating fresh water fish (raw, undercooked) containing fluke larvae
HOSTS
Definitive: Variety of mammals, including
humans, swine and rodents (zoonosis).
1st Intermediate: Snails
2nd Intermediate: Freshwater fish
GEOGRAPHIC RANGE
Japan, China, Taiwan and Southeast Asia and
even some in the United States.
Common among Asian immigrants.
MORPHOLOGY
Hermaphrodite
Unsegmented
Leaf-
shaped
Bilaterally symmetrical excretory system
Bear 2 suckers
Ventral
Oral
Oblong
shaped
Flat (platyhelminthes)
10-25 mm in length
CLINICAL SIGNS
Dwells in the bile ducts, causing inflammatory
reaction, hyperplasia and sometimes
carcinoma of bile ducts.
Adult metacercariae is capable of consuming
all bile produced by the liver, therefore,
preventing the human host to digest (especially
fats).
Obstruction of bile duct by parasite or eggs
leads to biliary obstruction and cholangitis.
CLINICAL SIGNS (CONT.)
Acute Abdominal pain, nausea, diarrhea,
eosinophilia and loss of appetite
Long-standing infections can be fatal
Incubation period: viable; depends on the
number of worms present
DIAGNOSIS/TREATMENT
Microscopic demonstration of eggs in stool.
Duodenal aspirate-most diagnostic method
Adult fluke can be recovered during surgery.
Treated with Praziquantel (drug of choice) or
albendazole.
INTERESTING FACTS
Believed to be the third most prevalent worm
parasite in the world!
Currently infecting approximately 30,000,000
humans!!
The adult liver fluke can live in the bile ducts
from anywhere between 30-40 years!
LIFE CYCLE
ADULT FLUKE