Transcript 2015 Retreat Presentations

Structural and Computational
Biophysics Training Program
Program Retreat for T32-GM095440
April 24, 2015
Wake Forest Biotech Place
Room 155
Program Administration
Co-Directors
Poole Lyles
Executive Committee
Poole Lyles Salsbury King
External Advisory
Committee
LeCompte Estes
Training
Faculty
Student
Trainees
Program Curriculum
Molecular and Cellular
Biosciences
Biochemistry
Molecular
Medicine
Chemistry
Physics
Molecular
Genetics
Discipline-Specific Coursework
MCB 711
Biological Systems
and Structures
PHY 607
Biophysics
Advanced Courses in Structural
and Computational Biophysics
Center for Structural Biology
Seminar Series
Training in Responsible Conduct of Research
Structural and Computational
Biophysics Discussion Group
Training for a Diversity of Careers
• Career workshops
• SCB-sponsored workshops
• Shared workshops with Graduate School and other T32
training programs
• Courses
• Principles and Practice of Teaching Biochemistry (BICM 717,
718)
• Drug Discovery, Design, and Development - Molecules to
Medicines (CHM 740, also listed as BICM 740)
Training for a Diversity of Careers (cont.)
• Internships
• Biotechnology (Targacept, Keranetics)
• Pharma (GSK)
• Tech Transfer (Wake Forest Innovations)
• Intellectual Property (Kilpatrick Townsend & Stockton, LLP)
• Combined Degrees
• Ph.D.-M.B.A.
• M.D.-Ph.D.
Recruitment of Trainees
• Web-based recruiting and application
• Career Day at Wake Forest
• Campus visits
• Masters degree program
• Mathematics, Computer Science, Physics, Chemistry,
Biomedical Science
• Certificate Program in Structural and Computational
Biophysics
Recruitment of Members of Minority Groups
Under-represented in Science
• Attendance at national meetings (NIGMS TWD,
ABRCMS)
• Partnership with North Carolina A&T State University
• Participation in MARC Program (T34-GM083980, Mary Smith,
PI)
• Participation in BUILD grant application
• Attendance at annual MORE-STEM fair
• Research collaborations
• Participation in PREP Program (R25-GM064249, Debra Diz,
PI)
Program Evaluation
• Student evaluations at annual committee meetings
according to their Individual Development Plans
• Course evaluations by student surveys and by
coordination with course directors
• Individual training program evaluations by anonymous
exit interviews with the Dean of the Graduate School.
• External program reviews
Student Discussion Groups
Session 1
Student
Macnamara
Lawson
Nilsson
Mukherjee
Godwin
Mauney
Wang
Yang
Xiao
Dushime
Davis
Zahid
Black
Belanger
Lucas
Davidson
Su
Melvin
Session
Group
1
1
1
1
1
2
2
2
2
2
3
3
3
3
4
4
4
4
Student
Lawson
Mauney
Dushime
Belanger
Melvin
Macnamara
Godwin
Xiao
Black
Su
Mukherjee
Yang
Zahid
Davidson
Nilsson
Wang
Davis
Lucas
Group
1
1
1
1
1
2
2
2
2
2
3
3
3
3
4
4
4
4
Recommendations of External Advisory Committee
• Inter-campus communication: course listing, transportation,
internet access
• Training faculty size and composition
• Program cohesiveness and intellectual focus
• Curriculum and outcome evaluation
• Certificate Program and internships not widely understood
• Communication and interaction among students and faculty
• Value added
T32 GM095440: Structural and
Computational Biophysics Training Program
Goal: To bridge the gap between biomedical sciences
and more basic quantitative sciences
Interdisciplinary Research at WFU
COBCAP
consortium of biological chemistry and physics
(2002 retreat, 34 faculty across campuses)
applying chemical and physical theory and techniques to
biological problems
•
shared resources
•
combined seminars
•
cross-departmental teaching
•
cross-departmental research opportunities
• Translational Science Center
• Center for Molecular
Communication and Signaling
Dany Kim-Shapiro
(Biophysics)
Interdisciplinary Research at WFU
COBCAP
consortium of biological chemistry and physics
(2002 retreat, 34 faculty across campuses)
Recruitment of Reynolds Professor
in Computational Biophysics:
Jacquelyn Fetrow (Physics & CompSci)
Dany Kim-Shapiro
(Biophysics)
Interdisciplinary Research at WFU
Bowman Gray Technical Center
2003
2004
2006
2008
2011
2012
•Center for Structural Biology
move to BGTC, near WFU
Interdisciplinary Research at WFU
2003
2004
2006
2008
2011
2012
•Center for Structural Biology
•GAANN grant application (Fetrow)
•Structural and Computational Biophysics Journal Club
Interdisciplinary Research at WFU
2003
2004
2006
2008
2011
2012
•Center for Structural Biology
•GAANN grant application (Fetrow)
•Structural and Computational Biophysics Journal Club
•DMS-NSF/NIGMS Mathematical Biology Initiative (Funded), 2005-2009
(redox biology/proteomics with mathematical modeling)
•Certificate Program: Interdisciplinary Graduate Track in Structural and
Computational Biophysics at Wake Forest University
•Interdisciplinary Drug Discovery course (Hantgan)
•Molecular and Cellular Biology unified curriculum for incoming Ph.D. stud
•Predoctoral Training Program (T32) in Structural and Computational
Biophysics (Lyles & Poole PIs, Salsbury & Fetrow, executive board)
•CSB & Biochem, with Immunol/Microbiol, Phys/Pharm, Bioengineering,
move to Biotechnology Place
Training Grant Award, 2011-2016
July 1, 2011, Start of Predoctoral T32 Training Grant (2 slots, then 4
slots/year)
Continued SCB Discussion Group, monthly at Foothills Brewery
August 25, 2014, External review of T32-GM095440
Juliette Lecomte, Johns Hopkins
Mary Estes, Baylor
April 24, 2015, SCB Retreat
May 25, 2015, Deadline to submit competitive renewal
Sept-Oct 2015, expected site visit before Nov. study section meeting
Training Grant Award, 2011-2016
2011-2012:
Laura Dillon (Wang, Biochemistry, yr 5)
Andrea Belanger (Kim-Shapiro, Physics, yr 2)
2012-2013:
Andrea Belanger (Kim-Shapiro, Physics, yr 3)
Chris Mauney (Hollis, Biochemistry, yr 2)
Thomas Poole (King, Chemistry, yr 2)
Amanda Smelser (Macosko, yr 2) ** NSF fellowship
2013-2014:
Chris Mauney (Hollis, Biochemistry, yr 3)
Thomas Poole (King, Chemistry, yr 3) ** GSK internship
Janelle Leuthaeuser (Fetrow, yr 4)
Jade Mims (Furdui, yr 2)
2014-2015:
Janelle Leuthaeuser (Fetrow, yr 5)
Jade Mims (Furdui, yr 3)
Reed Lawson (Lowther, yr 2)
Ryan Godwin (Salsbury, yr 2)
Faculty in SCB Training Program
Departmental Affiliations
Cristina
Furdui
Internal Medicine
Uli
Bierbach
Bruce
King
Section on Molecular Medicine
Biochemistry
Tom
Hollis
Martin
Guthold
Chemistry
Todd
Lowther
Physics
Fred
Perrino
Dany
Kim-Shapiro
Jed
Macosko
Doug
Lyles
Leslie
Poole
Suzy Torti
Dave Horita
Yuh-Hwa Wang
Fred
Salsbury
Jacque
Fetrow
Faculty in SCB Training Program
SCB Related Facilities
Mass
Spectrometry
Spectroscopy
Triple Quad, Q-ToF,
LTQ-Oribtrap (Velos
& XE), MALDI-ToF
Cristina
Furdui
Uli
Bierbach
UV-Vis & Fluor,
Stopped-flow
fluorimeter, timeresolved fluorimeter,
CD, EPR
Bruce
King
Xray
diffractometers
CSB: 1 generator,
2 detectors
Martin
Guthold
Tom
Hollis
Todd
Lowther
NMR
Bruker 300,
500 & 600 MHz
Dany
Kim-Shapiro
Jed
Macosko
Fred
Perrino
Protein analysis
Analytical
Ultracentrifuge, SPR,
DLS, Typhoon
scanner
Scanning Tunneling
& Atomic Force
Microscopes, TEM,
SEM, LSCM
Doug
Lyles
Leslie
Poole
Nanotechnology:
NextGen
Sequencing
Computational
Resources
Fred
Salsbury
Jacque
Fetrow
CSB Linux cluster and
graphics facility,
DEAC cluster
Interdisciplinary Research at WFU
C
O
B
C
A
P
•Center for Structural Biology (2003), new site at BGTC
•GAANN grant application (Fall 2003)
•Structural and Computational Biophysics Journal Club (Spring 2004)
•DMS-NSF/NIGMS Mathematical Biology Initiative, (Fall 2004): 2005-2009
(redox biology and proteomics with mathematical modeling using
computational algebra and Bayesian tools)
•Curriculum changes to add advanced training in structural biology (2005), unified
basic curriculum for molecularly-oriented biomedical Ph.D. students (2006),
Interdisciplinary Drug Discovery course (2008)
•Certificate Program (2006): Interdisciplinary Graduate Track in Structural and
Computational Biophysics at Wake Forest University
•Predoctoral Training Program (T32) in Structural and Computational Biophysics
(Lyles & Poole PIs, Salsbury & Fetrow, executive board)
Interdisciplinary Science Centers
Medical Center:
Comprehensive Cancer Center
Translational Science Institute (MMTS & MGG)
Reynolda Campus:
Translational Science Center (to promote and maintain functional health in aging)
Center for Molecular Communication and Signaling