Transcript Membrane Biophysics and Synaptic Physiology

Membrane Biophysics and
Synaptic Physiology
Explanation of cellular and circuit
communication using the basic principles
of biophysics.
Explanation of basic biological phenomenon
using physical principles.
Membrane Biophysics and Synaptic
Physiology
•Channel
function
•Channel
function – mitochondrial channels as a model
•Transporters
•The
classical biophysical transporter mechanisms
•Unusual mechanisms of transport
•Gap
Junctions
•Voltage
•Synaptic
gating, chemical gating, and permeation of gap junctions
transmission
•Calcium
dependence of release, two models and mechanisms?
•Multivesicular release, when and where?
•Synaptic
plasticity
•Postsynaptic
mechanisms, presynaptic mechanisms
•Detailed mechanisms
•Dendritic
and synaptic integration
•Direction
selectivity as a model
Membrane Biophysics and
Synaptic Physiology
What you need to do:
PARTICIPATE – sign up for paper presentations
and read all assigned papers and come ready to
discuss/question papers.
In small groups (1-3 people depending on class
size) write a brief proposal to use biophysical or
physiological methods to address an important
(or interesting) question in neuroscience (see
handout for details).