Transcript Tissue Engineering of the Heart

By: Dan Tamayo
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Electrospun Nanofibers are polymer solutions
that are pumped through a syringe
They form an ultrafine fiber that are layered
on top of each other to form a mesh
This mesh can be used to culture and
cultivate cells as a scaffold in tissue
engineering
http://www.jove.com/video/2494/electrospinningfundamentals-optimizing-solution-and-apparatusparameters 2:23
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Used for tissue engineering scaffolding
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Can be used to deliver medication
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1902- Electrospinning was first discovered by
Marley and Cooley
1934- The apparatus was designed and
patented
1940- The design was perfected and a new
apparatus was patented, this is the apparatus
and technique we use today
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Today there are ways that nanofibers can be
electrospun while infused with medication.
While these nanofibers biodegrade, the
medication is evenly released throughout the
body.
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Research
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Difficult to do
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We will be able to make scaffolding out of
materials and chemicals that mimic human
proteins and tissues identically.
The optimal scaffold will be found to make
cells grow, mature and direct cell migration
to the best of their ability.
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Meng, Z & Zu, X (2011) Preparation and
characterization of electrospun PLGA/gelatin
nanofibers as a potential drug delivery
system. Colloids and Surfaces B: Biointerfaces. 84
(1) 97-102
Chinwe Nwachukwu, C (2010) Electrospinning
protein nanofibers to control cell
adhesion. University of South Florida Scholar
Commons. 55 (3)
Subbiah, h & Bhat, G (2005) Electrospinning of
nanofibers. Applied Polymer Science. 96 (2) 557569