Transcript bledsoe_V1_ch09

Paramedic Care
Principles & Practice
Volume 1
Introduction to
Advanced Prehospital Care
Second Edition
Chapter 9
General Principles of
Pharmacology
Figure 9-1
New drug development timeline. (United States Food and Drug Administration website,
http://www.fda.gov/fdac/special/newdrug/testing.html)
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-2 A Broselow tape is useful for calculating drug dosages for pediatric patients. (Courtesy Broselow
Corporation)
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-3
Functional organization of the autonomic nervous system within the overall nervous system.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-4
Effects of TCAs on reuptake of serotonin and norepinephrine.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-5
Components of the autonomic nervous system.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-6
Organization of the parasympathetic division of the autonomic nervous system.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-7
Distribution of the parasympathetic postganglionic fibers.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-8
Physiology of a cholinergic synapse. Acetylcholine is released from the presynaptic nerve and stimulates
receptors on the postsynaptic nerve. Subsequently, acetylcholinesterase breaks down the acetylcholine and the
presynaptic nerve fiber takes up the products.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-9
Distribution of sympathetic postganglionic fibers.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-10
Organization of the sympathetic division of the autonomic nervous system.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-11 Physiology of an adrenergic synapse. Norepinephrine is released from the presynaptic nerve and
stimulates receptors on the postsynaptic nerve. Subsequently, the norepinephrine is either taken up by the presynaptic
nerve or deactivated by enzymes in the synapse.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-12
Blood flow through the heart.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-13
Cardiac conductive system.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-14
Ion movements in the depolarization and repolarization of slow and fast potentials.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.
Figure 9-15
Reentrant pathways.
Bryan E. Bledsoe, Robert S. Porter, and Richard A. Cherry
Paramedic Care, Principles & Practice: Introduction to Advanced Prehospital Care
Copyright ©2006 by Prentice-Hall, Inc.
Upper Saddle River, New Jersey 07458
All rights reserved.