Transcript RAMOT ATHENS

From Lecture Hall to
Production Floor
Academia
Industry
Ramot at Tel Aviv University Ltd.
Presented by Larry Loev
Academia – Common Myths
• Research is not applicable to the real
world
• University personnel don’t understand
industry time frames
• Industrial standards can’t be maintained
• The urge to publish damages
confidentiality
Why Academia?
• Top researchers
• Peer reviewed technology
• Lab facilities
• “Cross-fertilization”
• Technologies with wide applications
• IP vigorously protected
Challenge: Contrasting Cultures
University
Corporate
Social responsibilities
Shareholders responsibilities
Pure scientific driven research
Specific objectives, product focused
Create new knowledge
Develop new products
Applied research
Basic research
Publications & collaborations
Ownership & secrecy
Sharing of material
Control of material
The Facilitator
The University Tech Transfer Office
Case Study: Ramot at TAU
• Ramot Objectives
To foster, initiate and lead the transfer of
new technologies from the laboratory to
the marketplace
To strengthen the relationship between
University research community and the
business community
Ramot - Board of Directors
• Industry, Venture Capital, Law
– Mr. Dov Lautman, Chairman of
Delta Galil Industries
– Dr. David Haselkorn, former
president of Clal
Biotechnologies
– Mr. Moshe (Mori) Arkin, Vice
Chairman of Perrigo
– Mr. Hemi Peres, GP, Pitango
Venture Capital
– Mr. Shmaryahu Shapiro, CEO,
Technorov holdings
– Ms. Tally Eitan, Adv., Eitan Law
Group
• University leadership & scientists
– Professor Hagit Messer-Yaron,
Ramot Chairperson,
VP Research & Development
– Professor Zvi Galil, President
– Mr. Mordehai Kohn, Director
General
– Professor Dany Leviatan, Rector
– Professor Yair Aharonovitz,
– Professor Yoel Kloog, Dean,
Faculty of Life Sciences
Tech Transfer Process
Discovery &
Innovation
Patenting &
Follow Up
Business
Evaluation Marketing
Development on Contract
Strategy
Revenues
Academic Basic and
Applied Research
Ramot Organization
Business Development
Engineering, Computer Science, Exact Sciences
Life sciences
Medical devices
IP management
Legal
Bridging the Development Gap
• A Development Gap lies between discovery and
commercialization
• Required: applied research, first prototype stage
– Looks like a product, performs certain specs
• Solution: feasibility research
– Sponsored by target licensee
– Sponsored by special funds (Ramot Fund,
Partnership, etc.)
Deal Models
Research and
Development Agreements
Funded by companies,
Israeli government
Licensing Deals
Licensing of IP, know how
to an existing company
 Research Funds
 Fees and Milestones
payments
 Running Royalties
 Equity participation
New venture formation /
Spin-offs
Licensing of IP to the
start-up company
“Lines in the Sand”
• IP - the heart and soul of a University’s
property
• Product Diligence – Responsibility to
the public
Tel Aviv University
About Tel Aviv University
•
•
•
•
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Established 1956
9 faculties, 24 schools, 105
departments
over 100 research institutes
30,000 students, 1,800 of
them are doctorate students
2,200 faculty members
Research Highlights
Life sciences (120 researchers(
Medicine (130 researchers(
Exact sciences (240
researchers(
Engineering (110 researchers)
600 researchers are affiliated
with the main medical centers in
greater Tel Aviv area
Thank You
Larry Loev
Manager Business Development,
Engineering and Physical Sciences
[email protected]
www.ramot.org
Extra Slides
Development Gap
Industry Requirements
A prototype, Looks like a product, performs certain specs
Pre-clinical results , efficacy in animal models, Toxicology


funding
Potential licensee point of view
(answer the right questions…)
 Funding of Research by target licensee
under an R&L/R&O agreement
 Funding of Research by special funds:
Stringent screening process based on both
commercial and scientific criteria.
Plan, Budget & Milestones
Stringent monitoring of the process.
Bridging the Gap (I)

Philanthropic funds

Tel Aviv University Fund for Applied Research*

The Colton Family Next Generation Technologies Institute
 “TAU Fund for Applied Research” supports 7-10
projects per year, $3M in 2003-6
 Projects are selected following a stringent
process by Ramot and a professional committee,
to meet commercial as well as scientific criteria
 “The Colton Fund” - Matching funds by Johnson
& Johnson
* Funded by the Yeshaya Horowitz Association , Jerusalem
Bridging the Gap (II)
 A corporate partner allocates an annual amount
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to support of research in pre-defined areas of interest.
The fund solicits highly promising projects with IP position,
development plan and clearly defined commercialization
path
A joint steering committee of the corporate partner,
TAU and Ramot evaluated and selects projects
Ramot provides strategic and scientific guidance
with a clear market focus
The corporate partner has certain rights in the IP
generated in the research
Two such multi-million dollar funds are currently
operational: nano-technology and smart-cards
Bridging the Gap (III)
TAU-Tech
TAU Future Technology Partnership (TAU-Tech)
Return on
investment
investment
$8.5M
Ramot:
Tel Aviv
University
technologies
Technology
management
Business development
Technology transfer
Industry
Licensing:
royalties and fees
Start-ups:
Equity participation
TAU-Tech Projects
Biotechnology
 Drug candidates for Alzheimer’s Disease
 Drug candidates for type II diabetes
 Novel cancer targeted drug delivery system
Medical Devices
 Direct lung fluid monitoring system for
congestive heart failure patients in Clinical Trials
 Optical Micro-Biosensors for Biomedical Diagnosis
Energy & Electronics
 Fuel cells for mobile electronics and industrial applications
 Micro-battery on a chip
Commercialization
paths
IP Protection & Commercialization Strategy: License
Mouthwash
R&L (Israel)
Product
R&L (UK)
Product
20% UK
market share
Schizophrenia
Alzheimer’s
R&L
(BioLineRx)
TAU Fund
Proof of concept
Drug Candidate
TAU Tech
Phase II – Q4 ‘07
•Lead compound
•Pre-clinical package
R&L
Pipeline – Bio/Pharma
Pipeline (II)
Diagnostic, medical devices and agro pipeline
Engineering / exact sciences pipeline
Current Available
Bio-Medical Technologies
Pharmaceuticals/Biotechnology
• Cardiovascular & Angiogenesis
• Alzheimer’s Disease
• Amyloid Diseases
• Cancer
• CNS
• Diabetes
• Drug Delivery
• Onychomycosis
• Stem Cell Therapy
• Virology
Diagnostics
• Liver Diseases
Medical Devices
• Lung fluid monitoring
• Drug delivery
• Continuous non-invasive blood
pressure monitoring
• Magnetic resonance imaging of
macromolecules and connective
tissue
• Advanced Echocardiography
TAU and Ramot Links
TAU Research Catalog: www.tau.ac.il
Research
Research Catalog
Ramot Available Technologies: www.ramot.org
Available Technologies