Transcript center for clinical and translational science

University of Kentucky
Center for Clinical and Translational
Science (CCTS)
November 2015
Stephen W. Wyatt, DMD, MPH
Senior Associate Director
Center for Clinical and Translational Science
University of Kentucky
CCTS History
1985
General Clinical Research Center
Initial Award: 5 Competing Renewals, ending March 2008
2002
University of Kentucky Clinical Research Organization
2005
RFA for Clinical and Translational Science Awards (CTSA) released
2006
Center for Clinical and Translational Science (CCTS) formed, reporting to the Provost
2006 – 2010 CCTS Growth, Consolidation, Transitions:
2006: CTSA Planning Grant funded (9/2006 - 9/2008)
2009: Consolidation of GCRC/CRO → CR-DOC
2007-10: CTSA Submissions – Jan 07, Nov 07, Oct 08, Oct 09, Oct 10
2011
Funded CTSA
2015
New Submission CTSA U54
Goals as a CTSA Hub
 Champion innovation in the full spectrum of clinical & translational research
 Educate the workforce of the future
 Engage our communities in biomedical science to improve quality of life of the
populace of Central Appalachia
UK has 16 colleges, with 11 involved in the UK CCTS (including six biomedical colleges)
on one central campus. This creates a closely knit unifies academic community and
positions the UK CCTS to demonstrate the impact of collaborative translational
research and leadership in team science
Specific Aims of the CCTS
Aim 1
Lead institutional innovation in the delivery of efficient, effective
clinical and translational research
Aim 2
Develop a diverse workforce across multiple disciplines that
advances translational research and excels in team-based science
Aim 3
Meet the unique needs of Central Appalachian residents by
extensively engaging and collaborating with our regional, rural,
and community-based partners
Specific Aims of the CCTS
Aim 4
Catalyze innovative research, including novel drug development and
informatics methodologies, with particular focus on bringing innovation
to special populations and across the lifespan.
Aim 5
Create an efficient clinical trials network centered at UK and
extending to our partnering medical centers in order to serve as an
essential, leading component of the CTSA consortium for engaging
with participants from rural Central Appalachia
Major Accomplishments to Date
 Created integrated home for clinical & translational research to promote scientific
progress & discoveries at every phase of the translational continuum
 Recognized locally and regionally for catalyzing change
 Fundamentally transformed the research environment at UK and throughout
Central Appalachia
 Development of robust Appalachian Translational Research Network across
four states, with integrated research partnerships including other CTSA hubs
 Positions CCTS to lead local, regional and national research efforts to address
the significant health disparities in this population
CCTS Functions
• Administrative Core
• Organization, Governance, Collaboration and
Communication
• Diversity
• Evaluation and Continuous Improvement
• Quality and Efficiency Goals
• Informatics
• Community and Collaboration
• Community Engagement
• Collaboration and Multi-Disciplinary Team Science
• Translational Endeavors
• Translational Workforce Development (TWD)
• Pilot and Translational Clinical Studies (PTC)
• Research Methods
• Biostatistics, Epidemiology and Research Design
(BERD)
• Regulatory Knowledge and Support (RKS)
• Hub Research Capacity
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Integrated Special Populations (ISP)
Participant and Clinical Interactions (PCI)
Network Capacity
Liaison to Trial Innovation Center (LTIC)
Liaison to Recruitment Innovation Centers (LRIC)
ATRN
Drug Discover & Development
Institutional Career Development Core
NRSA Training Core
Appalachian Translational Research Network (ATRN)
Connecting Central
Appalachian institutions
and communities with
national CTSA network
resources to facilitate
their active engagement
in multi-center research
studies.
ATRN Aims
Aim 1
Promote collaborative clinical and translational research (CTR), team
science and workforce development among the ATRN partner
institutions with an overall goal to benefit the health of residents in
Central Appalachia
Aim 2
Enhance UK CCTS Network Capacity to recruit study participants and to
deliver clinical trials in Central Appalachia
Aim 3
Develop the translational workforce at Marshal University with a focus
on informatics, regulatory systems and regulatory administration,
resulting in a strong partnership for multi-center clinical trials
Regional Reach Map
UK: 16 colleges on one campus
Community Engagement Aims
Aim 1
Develop new innovative strategies to engage Kentucky and Central
Appalachian communities and partners in the full spectrum of CTR,
enhancing responsiveness to community needs, while addressing the
region’s health challenges
Aim 2
Catalyze the development and dissemination of best practices for
engaging communities in CTR and fostering team science, in
cooperation with our Appalachian Translational Research Network
(ATRN) partners, including other CTSA hubs
Community Engagement Aims
Aim 3
Implement strategies for developing and sustaining diverse, multidisciplinary research teams to more effectively address the health
disparities prevalent in Kentucky and Central Appalachia
Aim 4
Transform our institutional culture so that collaborative team science
is valued and recognized during the promotion and tenure process as
essential to the success of translational science and discovery
Community Champions Cabinet
Community Leadership Institute of Kentucky (CLIK)
 A rigorous research training program for Appalachian
Kentucky community leaders to bolster local capacities
and solutions
 Established in 2014 with guidance from CTSA hubs at
Washington University, UCLA, and the University of
Cincinnati
Community Leadership Institute of Kentucky (CLIK)
 Applications for CLIK are solicited from diverse constituencies
including public health departments, FQHCs, school systems,
social service agencies, hospitals, etc.
 Selected individuals ( apprx. 50% were accepted) attend a
60-hour CTR training program designed to enhance:
• use of evidence-based programs
• research skills
• awareness and use of logic models and data mining
• presentation development, public speaking, grant writing,
and program evaluation skills
Questions?