Transcript SL_OpenTox_Intro

Seascape/Indira Ghosh, JNU
Introduction
Seascape Intro
Indo-US company with a mission to foster international
collaborative research, education and software knowledge
development/dissemination in the areas of Drug Discovery and
Nanotechnology. Operates from New Delhi and California and
has been in operation for over ten years
Seascape Role
Scientific Community Development & Integration in India and USA
Scientific & Technical Support for Software & Collaborative R&D
Projects
 New project searching, identification and matching with scientific
skills in India and USA
 Scientific Support, co-ordination and project management
 Software support, co-ordination and management
Education and Training
Seascape - Key People
Sunil Chawla, Founder:
• B.Tech from IIT Kharagpur, India
• M.Engg. from McGill-Montreal (Cancer Research Thesis
• MBA from UC Berkeley
• Experience: Apple, GE and Oracle in USA
Dr. Steve Bowlus, Comp Chemist
• Postdoctoral studies in toxicology and nutrition, University of Illinois
• MS, Ph.D, Organic Chemistry, University of Illinois, Urbana
Dr. Indira Ghosh, JNU, Sci Advisor
• Dean, School of info Technology, JNU, New Delhi
Dr. Indira Ghosh, JNU Introduction
Dr. Indira Ghosh, currently Dean of School of Information Technology, JNU,
New Delhi is the Chief Investigator and Scientific Advisor working with
Seascape on the OpenTox collaborative project
Dr. Indira Ghosh - Background
• More than a decade of experience working in leading pharmaceutical industry
(Astra Zeneca, R&D Bangalore, India)
• Ph.D from prestigious Indian Institute of Science, Bangalore in the field of
molecular biophysics. Ph.D work on the enzyme specificity with respect to the
stereochemical aspects of ligands
• Ph.D thesis could be taken as initial scientific study towards the development of
field known as ‘docking’
• Post-doctoral appointment at University of Huston, Texas with Prof. J. A.
McCammon (currently at University of California San Diego, USA)
• Worked on implementation of many complex algorithms in the filed of
Molecular Dynamics, has contributed in development of free energy calculation
using perturbation method
Recent/Relevant Research
• Research related to designing inhibitors for acting on H+ K+
ATPase, drug design (QSAR and toxicity prediction) for the
lead series related to disease like tuberculosis and malaria, for
more than a decade during her association with AstraZeneca.
• Currently, she is supervising major project related to force
field development of Metalloprotease, excited state treatment
of proton pumping phenomena of the ATPase funded by
Ministry of Communication and Information Technology and
Department of Biotechnology, Government of India.
Recent/Relevant Publications
• An Information–Theoretical Measure of Similarity and a Topological
Shape and Size Descriptor for Molecular Similarity Analysis (IEJMD,3,350360, 2004)
•Developing an Antituberculosis Compounds Database and Data Mining in
the Search of a Motif Responsible (minimum common bioactive
substructure-MCBS) for the Activity of a Diverse Class of Antituberculosis
Agents (J. Chem. Info. Model, 46, 17-23, 2006)
•Mapping Selectivity and Specificity of Active Site of Plasmepsins from
Plasmodium falciparum Using Molecular Interaction Field Approach
(Protein & Peptide Letters, 14, 569-574, 2007)