Transcript Powerpoint File

Active Asthma Inhaler
Annemarie Alderson
Annie Saha, Stephanie Shaulis, Bob Toth
Project Mentor: Dr. Timothy Corcoran, PhD
February 15, 2005
Project Summary Revisited
• To design and develop a dry-powder, singledose, disposable inhaler
• To create a prototype that is self contained,
ruggedly constructed, weather and water
proof, lightweight, small, ergonomically
designed, and actively mobile
• To be used for asthmatic individuals that
desire a temporary alternative to traditional
devices during physical activity and/or in
extreme environment settings
Why a Dry-Powder Inhaler?
• 70% of patients using
MDI’s fail to use them
properly
• Only about 10%-20% of
dose actually reaches the
targeted airways with
MDI’s; most of medication
is caught in the back of
the throat
• Left: Mold of a human
throat made from a
cadaver (Courtesy Dr.
Corcoran)
Preliminary Prototype
Dimensions:
30mm x 20mm x 10mm
Achievements and Milestones to Date
• Drug Research, Availability and Purchasing
• Obtained USP-grade Albuterol Sulfate from Spectrum
Chemical, end of January
• Preliminary Particle Size Testing
• Results, January 31
• Materials Selection
• Contacted Andy Holmes at Swanson
• Prototype to be made of ABS Plastic
Preliminary Particle Size Testing
•Aerosol medications should have particle size between 2-5 um
•Sample readings from albuterol shown below
Work To Do
• Further Particle Size Testing of Albuterol
• Possibly Particle Size Sorting
• Particle Size Testing of Atropine Sulfate
obtained through Mentor
• Drug Dispersal Testing
• Determine Sealing Mechanism
• Aesthetic Considerations of Prototype
Possible Obstacles
• Sorting albuterol particle size to obtain
the smaller particles
• Airtight sealing mechanism to prevent
contamination/moisture
• Drug Dispersal in DPI’s
• Questions??