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Abstract
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Affiliations and addresses
Affiliations and addresses
Methodology
1. A549, PC-3 and TSU-PR1 cells were grown in
cell culture in RPM1 medium. Logarithmic phase
cells were exposed to PDX or PDX with PBCD
for 3 hrs and IC50 values in each case
determined after further growth in PBCD for 96
hrs.
2. The murine Lewis Lung, human LX-1 lung, A549
NSC lung, PC-3 and TSU-PR1 prostate and
MX-1 breast tumors were transplanted sc in
BD2F1 (Lewis Lung) or NCR-nu (human tumors)
mice.
3. Mice with well established tumors were treated ip
with an MTD of PDX (60 mg/kg) or PDX (60
mg/kg) and PBCD (125 mg/kg) q3-4d x 4.
4. Treated and control mice were evaluated for
tolerance and efficacy (tumor size) during and up
to 10 days after treatment.
90
80
70
60
50
East
West
North
40
30
20
10
0
1st Qtr
2nd Qtr
3rd Qtr
4th Qtr
References
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in this space. Any of the boxes can be
altered as to size and shape.
Chu P, Van S, Yen B, Berger T. Minocycline
Hyperpigmentation Localized to the Lips: An
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