Transcript 幻灯片
Important advantages of MPS In comparision to heparin多磺酸粘多糖显著优于肝素 + higher percutaneous absorption更高的透皮吸收率 + better anti-inflammatory efficacy更强的抗炎作用 + proved tissue regeneration有效促进组织再生 MPS is superior in percutaneous absorption, anti-inflammatory action and tissue regeneration compared to heparin 多磺酸粘多糖在透皮吸收、抗炎和促进组织再生方面优于肝素 Fast and continuous absorption of MPS at the site of disorder. The penetration rates of MPS highly exceed those of heparin. 多磺酸粘多糖能在患处快速而持续地吸 收。多磺酸粘多糖的透皮吸收率显著高 于肝素。 Ratio of the MPS and heparin concentrations (in microgram per gram tissue) in the different dermal layers after cutaneous administration of cream preparations, calculated to the same concentrations of active substance (0,35% weight). (according to Stüttgen et al.) MPS has a regenerative effect on a disturbed connective tissue metabolism. The synthesis of hyaluronate in tissue cultures of synovial membrane cells after administra-tion of MPS is considerably grea.ter than after that of heparin. 多磺酸粘多糖能改善受损结缔组织代谢从而促 进组织再生。多磺酸粘多糖吸收以后，在滑膜 细胞组织培养液中透明质酸酶的合成显著优于 肝素。 MPS inhibits superficial inflammatory processes. The anti-inflammatory action of MPS is clearly stronger than that of heparin. 多磺酸粘多糖有效抑制浅表炎症。多磺酸粘多糖的 抗炎作用显著强于肝素。 抑制％ *含其它复合物 透明质酸酶合成的增长率％ 肝素 多磺酸粘多糖 Increase in hyaluronate synthesis in synovial cell cultures by MPS in comparison to heparin. (according to Verbruggen/Veys) 多磺酸粘多糖与肝素比较：在滑膜细胞培养液中，透明质酸酶合成 的增长率。（根据Verbruggen/Veys等人的研究得出） Inhibition of unltraviolet erythema by MPS and commercial ointments containing heparin at various concentrations, referred to the intensity of the erythema of untreated controls. (according to Raake)多磺酸粘多糖和含有不同浓度肝素的软膏对 透明质酸酶的抑制，以红斑的强度为参照（根据Raake等人的研 究得出) Literature: Stüttgen, G., Panse, P., Bauer, E.: Arzneim.-Forsch./Drug Res. 40 (I), 4, 484, (1990); Raake, W.: Arzneim.-Forsch./Drug Res. 34, 4 (1984); Verbruggen, G., Veys, E.: Acta Rhumatol. Belg. 1, 75 (1977) Hirudoid® Cream/Gel: Composition: 100g of cream/gel contain: Mucopolysaccharide polysulfuric acid ester 300mg, corr. to 25000 U., determined by means of the activated partial thromboplastin time (APTT). Other ingredients: Cream: Glycerol, potassium stearate, wool wax alcohol ointment, emulsifying cetostearyl alcohol, myristyl alcohol, isopropyl alcohol, parabenes (E 218, E216), thymol, purified water. Gel: Isopropyl alcohol, polyacrylic acid, propylene glycol, fragrance, sodium hydroxide, purified water. Indications: Cream: Superficial phlebitis and venous thrombosis, inflammation of varices, treatment of varicosclerosation, haematoma, swellings, loosening of hard scars, improvement of scar formation after injuries, burns, operations, etc. Gel: Extensive treatment of varices, phlebitis and venous stasis, contusions and bruises, swellings, haematoma and reactive effusions.Contraindications: Hypersensitivity to one of the ingredients. Side effects: In single cases hypersensitivity reactions of the skin. Mode of administration and dosage: Hirudoid® Cream: should be applied once or twice daily, if necessary more often. Hirudoid® Gel should be applied several times daily and distributed gently. Hirudoid® gel contains alcohol and should therefore not be brought into contact with open wounds, the eyes or mucous membranes. The gel should not be applied under a dressing. Hirudoid® Cream/Gel: Depending on the size of the area to be treated, a length of about 3-5cm of cream/gel is usually sufficient. Hirudoid® Cream: Contact to injured skin, the eyes or mucous membranes is to be avoided. Hirudoid® Cream/Gel should be used until complaints have subsided. Hirudoid® Cream/Gel has also proven to be value in combination with physiotherapy such as massage, phono- and iontophoresis (the cream has to be applied under the cathode).