Transcript Lecture 18. Patches production. Perspectives of transdermal

As. prof. Beley N.N.
Ternopil State Medical University about Horbachevsky
Patches production.
Perspectives of transdermal dosage
forms development
Patche is dosage form for external
application that is capable of softening at
body temperature to adhere to the skin.
At room temperature emplastic mass is dense, but at the
human body it becomes soft and sticky.
When the temperature increases further patches begin to melt,
turning into a thick liquid.
For convenience, the patches are plastered over the fabric or
paper.
The patches are classified for the
purpose of:
1. Epidermatical patches
2. Endermetical patches
3. Diadermatical patches
Epidermatical patches
can be used:
1) to protect any part of the body from harmful
influences;
2) to close the disfiguring skin blemishes;
3) to bring together the edges of the wound;
4) for fixing on the skin surface dressings.
They must be sufficiently sticky, firmly to stick to the skin
and not irritate it.
Endermetical patches are patches in emplastic mass of which various
drugs for a therapeutic effect on diseased skin
can be administered.
Diadermatical patches

are patches with drugs, penetrating through the skin and
affecting water deeply lying tissue.
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Composition transdermal patches
Drug delivery
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The patches are classified:
1. For the composition: - ordinary
- rubber
2. For way of preparation: - patches in the mass
- patches plastered
3. For natures of the substances that are prevalent in emplastic
base, ordinary patches can be divided into four subgroups:
- Lead (Diachylon),
- Lead-pitch,
- Lead-wax,
- Pitch-wax patches.
Simple diachylon - solid
homogeneous mass of grayish
or yellowish color while heated
becomes sticky and tacky.
Composition:
Pb oxide (litharge)
Sunflower
Purified pork fat
Water purified enough.
-10.0 g;
- 10,0 g;
- 10,0 g;
Stages of the simple diachylon
obtaining:
1. Melting of the oil and fat
2. Shredding of the litharge
3. Sifting of the litharge
4. Mixing of the litharge with fresh boiling water
5. Mixing of suspensions of Pb oxide with alloy of oil and
fat
6. Production of the patches mass
7. Washing of the patches mass from glycerol
8. Drying patches
Elastic plastered patches
Composition:
Natural rubber
Rosin
Zinc oxide
Lanolin anhydrous
Liquid paraffin
Neozon D
- 25,7 pm
- 20,35 pm
- 32,00 pm
- 9,90 pm
- 11,30 pm
- 0,75 pm
Technology of elastic plastered
patches :
1. Preparation of rubber glue (dissolution of rosin and rubber in gasoline)

2. Obtaining feed substances that prevent aging (homogenization mixture of
lanolin with Anti-aging substance )
3. Preparation of zinc base (homogenization mixture lanolin, beeswax and zinc
oxide)
4. Mixing rubber adhesives, pastes and zinc substances that prevent aging of basis
(6 hours)
5. Putting of the patches mass on the base made of fabric on a moved belt
machines for plastering of mass (shredding)
Putting of the patches mass on the base
made of fabric
Putting of the patches mass on the base
made of fabric
Putting of the patches mass on the base
made of fabric
Steps of patches formation
Patches manufacturing
Patches manufacturing
Pepper Patch (Emplastrum capsici) is are produced in the
form of rectangular pieces of paper diverse size.
-11 % of the thick extract of capsicum (formulated
specifically for the patch)
- 0.3 % thick, herb extracts
- 0,3 % tinctures Aralia
.
Skin glue

liquid, leaving adhesive elastic strong film at the skin
after evaporation of the solvent. Skin adhesives are
otherwise called liquid adhesives, and relatively widely
used as epidermatical and endermatical patches
Transdermal drug delivery due
Electrophoresis
Thank for your attentive