Transcript catie study - the Peninsula MRCPsych Course

CATIE STUDY
Clinical Antipsychotic Trials of Intervention
Effectiveness
Effectiveness of Antipsychotic Drugs in patients with
Chronic Schizophrenia – Lieberman J et al (2005) NEJM
CATIE
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1493 Participants
57 US sites
5 arms
Olanzapine (7.5 to 30mg daily)
Perphenazine (8 to 32 mg daily)
Quetiapine (200 to 800mg daily)
Risperidone (1.5 to 6.0 mg daily)
Ziprasidone (later) 40 to 160mg a day
CATIE
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3 Phases
Initial randomisation (Phase 1)
Then re-randomised if no response
Paper here reports Phase 1
18 months
2001-4
CATIE
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18-65
DSM schizophrenia (chronic)
SCID –IV
Exclusions schizoaffective, learning disability,
only one schizophrenic episode, treatment
resistance, sensitivity known to any of drug
arms, “cognitive disorder”, clozapine,
pregnant or breast feeding, serious or
unstable medical disorder
CATIE
• Tablets of identical appearance for blinding
• Dosage flexible 1-4 tablets
• Concomitatnt medication permitted exceot
antipsychotics
• Monthly visits
• Half patients on other drugs assigned to once
daily and half to twice daily for drugs with od
regime as quetiapine and ziprasidone bd and
could unblind
CATIE
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ITT
Kaplan Meier
Cox proportional-hazards
MANOVA/MANCOVA