Transcript Mathematical modelling of Bone remodelling at cellular level

Suffering from Osteoporosis?
-Mathematical modeling of bone
remodeling at cellular level
Yanan Wang
31/10/2007
Osteoporosis
 How does
osteoporosis relate
to my work (bone
remodeling)?
Bone remodeling cycle at cellular level
Bone remodeling (Coupling)
Significance of bone remodeling
 Serving to adjust bone architecture.
 Helping to repair microdamage.
 Maintaing plasma calcium homeostastis.
Logical structure of the model
Reasons for including PTH
 PTH is currently involved in clinical trials.
 PTH 1-34 was recently approved by the Food
and Drug Administration of America (FDA).
Intermittent vs Continuous
Biomechanical control of bone remodeling
Effect of electromagnetic field on remodeling
Conclusion
The end
Thank you 