Transcript No Slide Title

ESM technology: enhancing drug performance
• Neutral molecules
pass freely through cell
• Pharmacokinetics
limited by clearance
from plasma
Intracellular
target
“Parent”
molecule
ESM technology: enhancing drug performance
• Linking motif to parent
creates novel IP
• Neutral parent/motif is
cell permeable
Intracellular
target
ESM technology: enhancing drug performance
• Linking motif to parent
creates novel IP
• Neutral parent/motif is
cell permeable
±
Intracellular
target
• Motif cleaved by
intracellular enzyme
leaving charged species
• Family of three
enzymes
• Charged species also
novel/patentable
• Expression of
one is restricted
to macrophages
• Charged species
accumulates in cell
Back