Transcript No Slide Title

The Role of Cortisol
in Health & Longevity
Presented by William Kraemer, Ph.D.
Professor of Kinesiology
University of Connecticut
This material has been prepared by Pharmanex to be used in
conjunction with general educational events and activities only.
Alterations or modifications of this presentation without the express
approval of Pharmanex is prohibited.
What is Cortisol?
• Cortisol is the body’s primary stress hormone
• “Fight-or-Flight” response
• Regulates inflammation, carbohydrate metabolism, cardiovascular
function, etc…
• BUT
concerns
too much cortisol for too long leads to health
Normal Diurnal Cortisol Rhythm
Cortisol Levels Throughout the Day
18
16
14
12
10
8
6
4
2
0
4AM
6AM
8AM
10AM Noon
2PM
4PM
6PM
8PM
10PM
Mid
2AM
Cortisol Response to Stress
0.25
cortisol (ug/dl)
LowWHR
HighWHR
0.20
0.15
0.10
STRESS
0
50
100
Minutes (Session 1)
Epel et al. Psychosom Med 2000;62(5):623-32
150
200
ACTH
Cortisol
50
Norepinephrine
18
1400
1300
16
30
20
14
1000
12
NE (ng/l)
Cortisol (µg/100 ml)
ACTH (pg/ml)
40
1200
1100
10
8
500
6
400
4
10
2
stress
0
-10 10
30
50
70
Trier Social Stress Test
(public speaking & arithmetic)
900
800
700
600
300
200
stress
0
-10 10
100
30
50
70
Time (min)
stress
0
-10 10
30
50
70
M. Altemus, Cornell University.
Cortitrol™
STRESS CONTROL FORMULA
Supports healthy cortisol levels*
Presented by Shawn Talbott, Ph.D.
Director, Scientific Affairs
Pharmanex, LLC
This material has been prepared by Pharmanex to be used in
conjunction with general educational events and activities only.
Alterations or modifications of this presentation without the express
approval of Pharmanex is prohibited.
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
What is Cortisol?
• Cortisol is the body’s primary stress hormone
• “Fight-or-Flight” response
• Required by the body for survival
• Regulates carbohydrate metabolism, cardiovascular function, etc…
•BUT
too much cortisol for too long leads to problems
• Repeated exposure to stressful situations (personal, family, work)
• Modern stressors do not permit fight or flight
• Stress hormones may not dissipate
• Stress leads to health consequences
Robert Sapolsky, PhD
Stanford stress researcher
Cortitrol™ Helps Control Cortisol to Cope with Stress
Cortisol Levels Throughout the Day
18
16
14
12
10
8
6
4
2
0
Stress
4AM
6AM
8AM
10AM Noon
2PM
4PM
6PM
8PM
10PM
Mid
2AM
Cortisol Levels Are Elevated In...
• Stressful situations
• Sleep deprivation
• Dieting / Restrained eating
Adults who need to control cortisol levels are…
• Frequently confronted with stressful situations
• Getting less than 8 hours of sleep every night
• Generally feel run down, lack mental focus
• Limiting caloric intake to lose weight
Stress and the Workplace
Psychological demands at work that exceed one’s capacity
to cope produce a variety of physiological responses that,
over time, lead to health concerns.
Work demands and low level of job control lead to changes in
cortisol levels.
Ganster et al. Journal of Applied Psychology, 2001, 86, 954-964.
Cortisol in the Media
More Than 1,000 News Articles Over the Past Year!
• Time, Washington Post, Men’s Health, Prevention,
Glamour, Shape, Woman’s World, Reader’s Digest,
Reuters, ABC, MSNBC…
1st International Symposium on Cortisol, Stress and
Health
• May 2002 - Experts from United States, Canada, and
Europe gathered in Park City, Utah presented emerging
research related to cortisol
New Book: The Cortisol Connection
• Published September 2002
The Solution: Cortisol Management
You can control cortisol levels via:
Stress Management Techniques
• meditation, coping strategies, etc…
Exercise
• Pharmanex Body Design
Nutrition
• Pharmanex Body Design
Dietary Supplements*
• LifePak™ + Cortitrol™ STRESS CONTROL FORMULA
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Common Anti-Stress Solutions
Valerian
Kava Kava
Melatonin
Tyrosine
None of these supplements directly address cortisol control
Cortitrol™ STRESS CONTROL FORMULA
- Health Benefits • Enhances feelings of wellbeing and
control in response to stressful situations*
• Improves performance and increased
vigor throughout the day*
• Better mental concentration and focus*
• Supports weight maintenance efforts*
Hint… CORTITROL for CORTIsol conTROL
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Proprietary Stress Control Formula
• Comprehensive formula addresses both direct cortisol
modulation and stress control
• Scientifically-validated ingredients in clinically
significant dosages
• Magnolia Bark (2% Honokiol), Ashwagandha, Passion Flower
• Epimedium (6:1 water extract), Garlic
• L-Theanine (70:1 all-natural extract)
• Phosphatidylserine
• Beta-sitosterol
Scientific Substantiation
Magnolia Bark
• anti-stress effects; non-sedating
Epimedium
• reduces cortisol levels during high stress; promotes
energy levels
L-Theanine
• increase alpha brain wave production; promotes relaxed
alertness and concentration; non-sedating
Phosphatidylserine
• reduces cortisol levels following strenuous exercise;
improves mental function
Beta-sitosterol
• balances cortisol:DHEA ratio; supports immune function
*References available from Pharmanex, LLC
Competitive Advantage
• First patent-pending dietary supplement that
supports healthy cortisol levels*
• Proprietary blend + Comprehensive Approach
• Modulates cortisol levels
• Helps combat stress
• Improves mental function
• Contains a proprietary, all-natural form of theanine
extracted from green tea leaves
• Manufactured according to the Pharmanex® 6S®
Quality Process
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Recommended Usage
• Everyone should use Cortitrol!
• Frequently confronted with stressful situations
• Getting less than 8 hours of sleep every night
• Generally feel run down, lack mental focus
• Limiting caloric intake to lose weight
• Combine with LifePak® Family
• Vitamin C, B vitamins, calcium, magnesium
Directions for Use
Take 2 capsules with your evening meal. For optimal
results take an additional (1) capsule with your morning
meal.
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