Transcript Moisture Transfer between Formulation Components in a

Drug Formulation / Drug Delivery
Raj Suryanarayanan (Sury)
Department of Pharmaceutics
College of Pharmacy
[email protected]
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Faculty Research Areas
 Biological Pharmaceutics (Pharmacokinetics,
Pharmacodynamics, Metabolism)
Elmquist, Fairbanks, Sawchuk, Zimmerman
 Physical Pharmaceutics (Materials Science)
Suryanarayanan, Sun
 Drug Delivery
Kandimalla, Prabha, Panyam, Siegel, Wiedmann
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Center for Translational Drug Delivery
Developing collaborative relationships with
pharmaceutical companies in the area of drug
delivery
Raj Suryanarayanan(Sury), Pharmaceutics
[email protected]
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Goals and missions of the Center
 Bring together faculty with interest in drug
delivery
 Leverage our comprehensive expertise in drug
delivery – develop collaborations with
pharmaceutical companies
 Work with the different administrative units to
expedite legal and contractual issues
 Serve as a platform for training grants and program
project grants that are focused on drug delivery
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AeroCore
Supporting research and product
development through inhalation
drug delivery
Core Activities
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Aerosol generation
Characterization of aerosol particles (output/particle
size distributions)
Exposure of rodents to aerosol particles or vapors
Measurement of chemicals deposited in the
respiratory tract and accumulation in blood of rodents
Gross and microscopic examinations of rodents
Disease induction in animal models (e.g. cancer)
1. Drug solubilization through engineering solid form
(nanocaging, solid dispersion, cocrystallization, salt
formation, etc.)
2. Tablet formulation and manufacturing process
understanding and control
3. Structure-mechanical property relationship in
organic crystals and powders
C.C. Sun
The aqueous solubility of poorly soluble drugs is significantly improved by
nanocaging.
Kandimalla lab drug delivery
projects
Design of nanotheranostics for the diagnosis
and treatment of cerebrovascular diseases.
Elucidation of biophysical properties of
endogenous macromolecules and their transport
across the cellular barriers, particularly the blood
brain barrier.
Development of novel drug delivery approaches
to disrupt bacterial biofilms.
Strategies to evaluate and enhance oxidative
stability of natural carrier oils.
Prabha Research Interests
Oral formulations to improve bioavailability of
poorly soluble drugs
Anti-angiogenic therapy for ovarian cancer
Sustained protein/gene delivery for chronic wounds
Photodynamic therapy for treating microbial
infections in chronic wounds
Panyam Research Interests
Targeted Antibiotic Delivery for Chlamydial Infections
NIAID/NIH
Magnetic Hyperthermia for Lung Cancer
Department of Defense
Polymeric Systems for Cancer Prevention/Treatment
NCI/NIH
Targeting Cancer Stem Cells
Randy Shaver Foundation
SIEGEL LAB
• Polymeric Drug Delivery Systems, Hydrogels
• Microfabricated Sensors (e.g. temperature, pH,
glucose)
• Intranasal Delivery of Low Solubility, Fast Acting Drugs
DZP in
Bloodstream
Diazepam (DZP)
prodrug administered
with converting
enzyme
“Crystallization” Horse
Unabsorbed DZP
Cleared in
Nasopharynx
“Absorption”
Horse
Application:
Canine Epilepsy
Starting Line
Finish Line