Transcript Essential Bioinformatics and Biocomputing (LSM2104

CZ5225: Modeling and Simulation in Biology
Introduction about the module
Prof. Chen Yu Zong
Tel: 6874-6877
Email: [email protected]
http://xin.cz3.nus.edu.sg
Room 07-24, level 7, SOC1,
National University of Singapore
What is expected:
• To learn from case studies how to develop models
of biological systems
• To learn the fundamentals in proteins, drugs,
sequence analysis, drug-protein interaction
modeling
• To develop models for predicting drug resistance
mutations, and pharmacognetic response to drugs
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Labs, Exams and Textbook:
Projects:
• Development of drug resistance mutation
predictors (25%).
• Development of predictors of pharmacogenetic
response to drugs (25%).
Final Exams (50%)
Textbook and web:
http://bidd.nus.edu.sg/group/teach/cz5225/cz5225.htm
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Topics covered:
•
Lecture 1: Introduction
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Lecture 2: Proteins
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Lecture 3: Sequence alignment methods
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Lecture 4: Practical use of sequence alignment methods and introduction of
projects
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Lecture 5: Drugs
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Lecture 6: Drug resistance mutations and model developments
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Lecture 7: Protein structure and structural modeling
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Lecture 8: Protein structural prediction methods
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Lecture 9: Pharmacogenetics and individual variation of drug response
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Lecture 10: Prediction system for pharmacogenetic response to drugs
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Lecture 11: Other modeling and simulation methods in biology
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