Transcript Presentation Title

Cloud-computing HPC simulation tools within
biopharmaceutical industry
Drago Kuzman, Matjaž Oven
Sandoz Biopharmaceuticals Mengeš
Lek Pharmaceuticals d.d., Slovenia
Novartis & Google partnership
...“information about blood sugar levels, which is
particularly useful for people with diabetes, could
be uploaded to smartphone devices and used by
doctors and patients to monitor the data almost in
real time“...
http://www.nytimes.com/2014/07/16/business/international
Apple step into Healthcare
...“The app for mobile devices will track statistics for
health or fitness, like a user’s footsteps, heart rate and
sleep activity“....
Mesi Simplifying Diagnostics, Slovenia
among top 10 finalists for $10 M XPRIZE
“Mesi's wristband continuously monitors patient activity
and vital signs, while modules called "shield," "to see," "to
hear," and "pee" provide additional information used to
make diagnoses. The system aggregates the data in a
smartphone app. “
http://www.mddionline.com/article/qualcomm-names-10-finalists-tricorder-xprize-mesi-simplifying-diagnostics
Opportunity for Slovenian pharmaceutical and IT industry
Partners on a project „Cloud-computing HPC simulation
tools within biopharmaceutical industry“
Biologics are more complex than small molecules and are
produced from living organisms
Modify host cells
(e.g., bacteria,
mammalian yeast) to
produce recombinant
proteins
Grow cells
under controlled
conditions
(fermentation)
Extract, refold,
purify
(downstream) –
generate drug
substance
Formulate to
stable finished
drug product (vial,
syringe, cartridge)
Biosimilar development costs are US$ 800 millions, development time is 8 years.
.
Goal of the project
Goal of the project is an introduction of the latest IT technologies (e.g.
high performance computing) into pharmacy in order to:
•
•
•
shorten development time (e.g. faster scale-ups)
improve success rate of process transfers (e.g. from pilot to
production scale)
improve production robustness by further process understanding
and on-line process monitoring
Cloud computing and big-data analytics
High performance computing in service of bioinformatics is a key
factor for the success of the project. Biopharmaceuticals are derived
by cell cultures, meaning that the production process understating
depends on big data analysis enabling insight into cellular processes.
Analysis will include cluster and cloud computing, big-data analytics,
graph theoretical approaches and mechanistical modeling.
http://ocw.mit.edu/courses/biology/7-343-network-medicineusing-systems-biology-and-signaling-networks-to-createnovel-cancer-therapeutics-fall-2012/
TurboInstitut
Conclusions
Contributions into SPS priorities:
•
•
»Health« priority: faster and cheaper development of
biomedicines and their production technologies
»Smart usage of resources« priority:
substantially
reduction of the resources (e.g. energy, human, materials)
by development of new tools for process development
and process monitoring
Developed tools and principles will have also wider
applicability for other industries like chemical,
environmental and food industries and will enable
novel opportunities in IT sector including startups like
Mesi!
Thank You
Drago Kuzman, Matjaž Oven
Biopharmaceuticals, Lek Pharmaceuticals d.d., Slovenia
[email protected]
[email protected]
www.lek.si