Transcript Porous Si Photonic Crystals

The Uses of Nanosensors: From
Smart Dust to Nano “Mother Ships”
Jack Ealy Workshop
La Jolla, CA July 2006
Professor Michael J. Sailor
UC San Diego
Dept. of Chemistry and Biochemistry
[email protected]
http://chem-faculty.ucsd.edu/sailor/
Death on the Danube
The Economist, 2/15/00
Environmental sampling
Lab
Field
Smart Dust
Kris Pister, UCB (1996)
Available:
•wireless radios
•data processing
•networking
protocols
Smart Dust
Kris Pister, UCB (1996)
Need:
•sensors
•power sources
Silicon vapor sensors
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Making a silicon nanostructure
20 mm
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Electrochemical machining
of nanopores
Silicon nanostructures mimic the
Calloodes grayanus
beetle shell
chitin
multilayer
2 mm
n = 1.73
n = 1.40
Chitin multilayer
Silicon nanostructures mimic the
beetle shell
Silicon multilayer
Silicon Microsensors
William R. Freeman, M.D.
and Lingyun Cheng, M.D.
Jacobs Retina Center
UCSD
Mother-Ships for Nanotherapies
Porous silicon
micro-particle in
the eye
color changes when
particle releases drug
Targeted Nanomachines
Diagnostic
Targeting
Self-Destruct
Activation
Sensor
UCSD Moores Cancer Center
NIH nanoTUMOR center
Erkki Ruoslahti, Burnham Inst.
Sangeeta Bhatia, MIT
Michael Sailor, UCSD
Therapeutic
Ruoslahti, Cancer Cell, 2002
Backup slides
Hazards of nanotechnology
Asbestos fibers (Nikon, inc)
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University of Wisconsin, Madison Asbestos Management Program
Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997January 1998)
As with any new technology, reasonable concerns about
potential hazards are appropriate.
Hazards of nanotechnology
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Shvedova, A. A. et al. Exposure to carbon
nanotube material: assessment of nanotube
cytotoxicity using human keratinocyte cells. J.
Toxicol. Environ. Health A 66, 1909-1926
(2003).
Derfus, A., Chan, W. & Bhatia, S. N. Probing the
Cytotoxicity of Semiconductor Quantum Dots.
Nano Lett. (2004).
5 nm CdSe
(A. Paul Alivisatos, UC
Berkeley)
Making a silicon nanostructure
20 mm
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Encoded particles self-assemble
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alkylated
oxidized
Magnetic manipulation of microparticles
30 nm magnetite
nanoparticles
[O]
Nature Mater. 2004, 3, 896-899.