Transcript Proliferation Kinetics [Torado GJ, Green H, JCB, 17, 299

Therapeutic Peptides for
Cardiovascular Disease and Cancer
Cam Patterson, MD, MBA, FACC, FAHA
Ernest and Hazel Craige Distinguished Professor
of Cardiovascular Medicine
Chief, Division of Cardiology
Director, Carolina Cardiovascular Biology Center
University of North Carolina at Chapel Hill
Anka N. Veleva, PhD, MA
Stuart L. Cooper, PhD
Department of Chemical and
Biomolecular Engineering
North Carolina State University
Department of Chemical and
Biomolecular Engineering
Ohio State University
Endothelial Progenitor Cells (EPC)
from Biology to Treatment
□
In 1997, EPC were first identified in adult
human peripheral blood
□
EPC are immature cells capable of
differentiating into mature endothelial cells
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EPC can play an important role in the
formation of new blood vessels
- mobilization from the bone marrow
- migration through the circulation
- incorporation into blood vessels
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Clinically, the number and function of EPC
have been positively linked with improved
endothelial function and regeneration
Rosenzweig A., NEJM, 348, 581 (2003).
Phage Display Technology to Identify Peptides
Specific for Endothelial Progenitor Cells
Veleva A. et al., Biotechnology and Bioengineering, 98, 306 (2007).
Peptides Immobilized on a Biomaterial Scaffold to
Improve Cyto- and Blood- compatibility of Implants
□ Stimulating endothelialization at the implant
surface will restore vascular homeostasis
early in the healing process
Veleva A. et al., Biomaterials, 29, 3656 (2008).
New Functional Tools to Target Tumor Vasculature
□ Tumor angiogenesis has a
critical role in promoting the
growth of most carcinomas
□ EPC play an important role in
angiogenesis-mediated tumor
progression
□ To utilize endogenous EPC as natural vectors to deliver
diagnostic and therapeutic reagents to tumors
Market Potential
□ Regenerative Medicine
- cell separations
- production of pure cell populations for allogeneic stem cell therapies
□ Medical Implant Technologies
to treat cardiovascular diseases, “off-the-shelf” products
- innovative intravascular stent systems
- small diameter vascular grafts
- pacemakers
- heart valve repair
- arterial septal repair implants
□ Oncology -
targeting of tumor-associated blood vessels
- non-invasive detection of small cancer tissue, primary tumors & metastases
- targeted therapeutics, development of highly specific drug delivery systems
- personalized medicine, monitoring efficacy of therapies