Transcript Slide - Indiana CTSI

Notre Dame: Drug Discovery Expertise and Resources
Chemical Structure and Synthetic Methods
Brandon Ashfeld
(brain cancer)
Paul Helquist
(antibiotics, cancer, lysosomal storage disorders)
Rich Taylor
(cancer, Alzheimer’s disease)
Biological Structure (Structure-based Design)
Shahriar Mobashery (antibiotic resistance, cancer metastasis, stroke)
Sergei Vakulenko
(antibiotics)
Olaf Wiest
(epi-genetics, lysosomal storage disorders, antibiotics)
Diagnostics and Delivery
Bradley Smith
(imaging and targeting agents, cancer, infectious disease)
Marvin Miller
(siderophore-antibiotic conjugates)
Haifeng Gao
(polymer-based nanostructures)
Basar Bilgicer
(ligand targeted liposomes)
Pre-Clinical Studies
Mayland Chang
(antibiotics, stroke and traumatic brain injury)
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Notre Dame: Drug Discovery Expertise and Resources
Chemical Structure Facilities
Nuclear Magnetic Resonance, X-ray Crystallography, Mass Spec and Proteomics
Chemical Synthesis and Drug Discovery Facility
Computer-Aided Molecular Design Facility
Biological Facilities
Genomics and Bioinformatics
Microscopy and Flow Cytometry
Integrated Imaging Facility
Institutes, Centers, and Initiatives
Harper Cancer Institute (University of Notre Dame and IUSM-South Bend)
Eck Institute for Global Health
Center for Rare and Neglected Disease
Advanced Diagnostics & Therapeutics
Analytical Sciences
Applied and Computation Mathematics
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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The number of FDA approved drugs decreased
significantly between 1996 – 2010 despite more
compounds prepared (combinatorial chemistry) and
assayed (high throughput screening).
Hit
Lead
Preclinical Studies
(Pharmacology & Tox.)
10,000 compounds 250 compounds
Clinical Trials
Phase 0, I, II, III
5 compounds
FDA Review/
Approval
1 compound
In addition to economic and bureaucratic factors, a
likely scientific cause for this trend rests in the fact
that the compounds produced and evaluated in
large pharmaceutical compounds represent a small
subset of chemical diversity space.
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The Warren Family Center for Drug Discovery
Facilitate internal cross-disciplinary collaborations by
providing chemical synthesis and medicinal chemistry
services.
Hit
Lead
Preclinical Studies
(Pharmacology & Tox.)
10,000 compounds 250 compounds
Organize the chemical products of past,
current, and future chemical synthesis
and create the Notre Dame Chemical
Compound Collection.
Promote external collaborations with regional
screening centers at Purdue, Indiana University School
of Medicine, and other academic facilities as well as Eli
Lilly, BMS and other industrial partners.
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Hit
Lead
Preclinical Studies
(Pharmacology & Tox.)
Clinical Trials
Phase 0, I, II, III
FDA Review/
Approval
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Hit
Lead
Clinical Trials
Phase 0, I, II, III
Preclinical Studies
(Pharmacology & Tox.)
FDA Review/
Approval
C
T
S
A
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The Indiana Drug Discovery Alliance (IDDA)
The Molecular Therapeutics program within the Indiana CTSI is pleased to
announce the creation of the Indiana Drug Discovery Alliance. The IDDA’s
objective is to promote and support promising early stage drug
discovery research. The IDDA will facilitate collaborative translational
research and partnerships through identification of complementary
expertise across and support for team building across diverse disciplines.
The IDDA will be a clearinghouse for drug discovery and development
resources available through Indiana-CTSI colleagues and, when
necessary, identify and fill gaps through the new, external partnerships.
The IDDA will seek to expand our current capabilities and knowledge base
by providing access to education resources to faculty and students on
translational drug discovery.
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The Indiana Drug Discovery Alliance (IDDA) Internal Advisory Committee
Yvonne Lai – Senior Scientist, Department of Psychology and Brain Sciences, Indiana UniversityBloomington
Jay McGill – Senior Director, Eli Lilly and Company and Translational Science Officer, Biocrossroads
Andrew Mesecar – Walther Professor of Cancer Structural Biology; Purdue University
Tim Ratliff – Professor of Comparative Pathobiology and Director of the Center for Cancer Research;
Purdue University
Scott Sheehan - Senior Director Molecular Design and Lead Generation Technologies, Eli Lilly and
Company
Richard Taylor – Professor of Chemistry and Biochemistry, Interim Director Warren Family Center for
Drug Discovery and Associate Vice President for Research; University of Notre Dame
Michael VanNieuwenhze – Associate Professor, Department of Chemistry, Indiana UniversityBloomington
Zhong-Yin Zhang – Harris Professor and Chairman, Department of Biochemistry and Molecular Biology,
Indiana University School of Medicine
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Call for Proposals
PROPOSAL DEADLINE; July 1, 2014
The IDDA has created a competitive program that will provide funds and/or
consultation to support early stage development of therapeutics. Small
grants will be available to support new collaborations and/or the use of core
facilities that enable the translation of fundamental discoveries related to
drug discovery. Critical research proposal feedback will be provided
from the team of experienced industry and academic experts within our
internal advisory committee as well as through ad hoc, project-specific
pharmaceutical expert reviewers. Funded projects will be developed in
consultation with the internal advisory committee.
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Call for Proposals
The IDDA currently seeks proposals through three classifications:
Type 1: Chemical Lead Development: Projects with unique chemical entities
seeking in vitro or in vivo biological screening and evaluation, molecular
target identification, computational design and medicinal chemistry services,
and/or early stage preclinical evaluation.
Type 2: Biological Target Validation: Projects with fundamental biological
targets seeking assay development, in silico screening, high-throughput
screening, hit identification, chemical synthesis and/or medicinal chemistry
services.
Type 3: Molecular Design and Library Development: Projects seeking to
utilize computational and medicinal chemistry core facilities for design and
synthesis of small molecules for placement in the CTSI chemical compound
collection.
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GENERAL GUIDELINES
1. Applicants must be full-time researchers (tenure, tenure-track, or research faculty)
within the Indiana-CTSI.
2. Funds are available up to $15,000 but budget and budget justification are not
required at this stage. Final budgets will be developed in consultation with
the internal advisory committee.
3. The proposal should be single-spaced and a maximum of two pages in length
(Arial, 11pt) with no less than 0.5 inch margins.
4. The proposal should be submitted through the CTSI Hub as a single PDF
document with naming convention, “principal investigator_IDDA_type#.pdf”.
The following must be included within the two-page limit:
1. Name, title and affiliation of applicant and co-investigators.
2. A brief background describing the drug discovery-related project emphasizing
therapeutic relevance and significance.
3. Current status of project.
4. NIH-style, 4-page biosketches for the PI and co-investigators should be included
as an appendix.
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