Transcript Environmental Toxicology - chulabhorn graduate institute

1
Program Management Committee
Assoc. Prof. Dr. Jutamaad Satayavivad
Chairperson
2
Program Management Committee
Dr. Panida Navasumrit
Dr. Daam Settachan
Dr. Nuchanart Rangkadilok
Dr. Piyajit Watcharasit
Dr. Jantamas Kanitwithayanun
Environmental Toxicology Overview
4
ET Curriculum - credits
Diploma
(credits)
M.S.
(credits)
Ph. D.
(credits)
Required Courses
12*
9
12
Elective Courses
12
15
12
-
12
36
24
36
60
2 years
2-3 years
3-4 years
Thesis
Total
Duration
*
Basic science (3) + Environmental Toxicology (9) = 12
5
ET Curriculum – core courses
•
•
•
•
Principles of Toxicology (3 credits)
Environmental Toxicology (2 credits)
Seminar in Environmental Toxicology (2 credits)
Environmental and Health Risk Assessment and
Management of Toxic Chemicals (2 credits)
• Detection of Environmental Pollutants and
Monitoring of Health Effects (3 credits)
6
Nature of Courses/Teaching
Traditional lectures – highly technical, i.e. mechanistic:
Principles of Toxicology; Immunotoxicology & Reproductive
Toxicology; Environmental Toxicology
Lectures with practical component:
Detection of Environmental Pollutants and Monitoring of
Health Effects
Lectures that include policy components:
Environmental and Health Risk Assessment and Management
of Toxic Chemicals; Health, Development & Environment
Others:
- Seminar in Environmental Toxicology
- Case Studies in Applied Biosciences
7
ET Research Goals
• Elucidate mechanisms through which chemical,
physical & biological agents in the environment
induce toxicity & pathogenesis, including cancer
• Understand effects of environmental pollutants &
industrial chemicals as modifiers of physiological
& pathological status, & influence of host factors
such as nutritional status & disease states on
toxicity & carcinogenicity of chemicals
• Develop new methods for detection of
environmental toxicants
• Understand gene-environment interactions
8
Examples of ET Research
• Exposure & health impacts of urban air pollution,
particularly carcinogenic compounds such as PAHs,
benzene and 1,3-butadiene
• Cellular responses to chronic arsenic exposure in
Southern Thailand
• Effects of vitamin B deficiency on toxicity of
benzene
• Biomarkers of exposure, effects & susceptibility in
environmentally & occupationally exposed people
• Detection of environmental toxicants by
dielectrophoresis
9
Research Interests
Researcher
Research Interests
• Metals and Pesticides: Effects on
Environment & Health
• Non-neuronal cholinergic functions:
Immunotoxicological aspects
• Nutraceuticals
Assoc. Prof. Dr. Jutamaad
Satayavivad
Head, Laboratory of
Pharmacology, CRI
• Pharmacological and Toxicological Studies of
Selected Medicinal Plants
10
Research Interests
Researcher
Research Interests
• Molecular mechanisms of environmental
pollutants
Dr. Panida Navasumrit
Laboratory of
Environmental Toxicology,
CRI
• Molecular epidemiology
11
Research Interests
Researcher
Research Interests
• Neurodegenerative diseases
• Cell Signaling
Dr. Piyajit Watcharasit
Laboratory of Pharmacology,
CRI
12
Research Interests
Researcher
Research Interests
• Development and refinement of whole-effluent
toxicity testing with local indicator species as a
monitoring tool for wastewater effluent quality
Dr. Daam Settachan
Laboratory of
Environmental
Toxicology, CRI
• Rodent models for inhalation toxicity testing to
determine health effects from exposure to
environmental toxicants
13
Research Interests
Researcher
Research Interests
• Contamination of toxic metals & pesticides
in food & environmental samples
• Phytochemical analysis & pharmacological
Dr. Nuchanart Rangkadilok effects of selected medicinal plants
Laboratory of Pharmacology,
CRI
14
Research Interests
Researcher
Research Interests
• Potential human health effects from exposure
to environmental pollutants and industrial
chemicals
• Evaluation of biomarkers of exposure, human
health effects & individual susceptibility to
carcinogenic pollutants
Dr. Jantamas Kanitwithayanun • Protective effects of selected medicinal plants
Laboratory of Pharmacology, against environmental pollutant-induced toxicity
CRI
15
16
CB, ABS & ET
• ET is relatively narrow in focus - measuring
exposures and effects, & understanding
mechanisms of action & modifying factors
• ABS focuses on disease & covers other factors,
including influence of environmental factors,
e.g. climate change, etc…
• Drug development pulls all programs together
– understanding target disease (ABS) to drug
discovery (CB) to drug testing (ET)
17
Chemical
Biology
MS
Core: 15
Elective: 9
Thesis: 12
Total: 36
PhD
15
9
36
60
• Principles of Applied
Biosciences
• Experimental Strategies
for Biological Problems
• Case Studies in Applied
Biosciences
• Advanced Organic
Chemistry
• Spectroscopic Methods
for Organic Compounds &
Biomolecules
• Drug Discovery &
Development
Applied Biological
Sciences:
Environmental Health
Environmental
Toxicology
MS
Core: 13
Elective: 11
Thesis: 12
Total: 36
MS
Core:
9
Elective: 15
Thesis: 12
Total:
36
PhD
13
11
36
60
• Principles of Applied
Biosciences
• Experimental Strategies
for Biological Problems
• Case Studies in Applied
Biosciences
• Pathobiology & Analysis
of Disease at the Organism
Level
• Pathobiology & Analysis
of Disease at the
Population Level
PhD
12
12
36
60
• Principles of Toxicology
• Environmental Toxicology
• Seminar in
Environmental Toxicology
• Detection of
Environmental Pollutants
& Monitoring of Health
Effects
• Environmental & Health
Risk Assessment &
Management
18