Transcript Drug form taxonomy

Drug Forms
Peter Johnson
SCHIN, Newcastle, UK
Work done in Prodigy 3 project
By Chris Wroe,
Medical Informatics Group,
Manchester University, UK
Motivation
• Decision support
• Chronic disease management guidelines
• Computer needs to be able to answer questions
such as :• “Is this patient on an inhaled steroid for asthma?”
• “on a sustained release tablet for angina?”
• Implies machine has explicit categorisation of
drugs by Indication, Chemical structure, Route of
admin, Form, etc.
Patient on
• Becodisks
• Dry powder for inhalation,
disks containing 8 blisters
of beclometasone dipropionate
• 100 micrograms/blister
Forms proposed
Spray
. Dermal Spray
. Inhalant
. . Inhalant Powder
. . . Inhalant Powder Capsule
. . Nasal Inhalant
. . Oral Inhalant
. Nasal Spray
. Spray with Adaptor
. Powder Spray
. . Inhalant Powder
. . . Inhalant Powder Capsule
Inhaled steroid for asthma
Route –
implies some forms
Aerosol, Dry powder
Drug class
Indication
‘Form’ in reality
Route of administration
Physical Form
+ Administration Action
+ Administration Device
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Inhaled
Powder
Form for chewing
Delivered by applicator
Route taxonomy
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topical to conjunctiva
topical to ear
topical to nose
topical to skin
topical to scalp
topical to oral mucosa
. buccal
sublingual
topical to teeth
oral (passing through oral cavity)
rectal
vaginal
intravenous
intrathecal
intraperitoneal
inhaled to lung
. inhaled to lung via nose
. inhaled to lung via mouth
Drug form taxonomy
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aerosol
bar
cake
disk
foam
gel
. jelly
gum
liniment
liquidEmulsion
lotion
ointment
particulate
. bead
. crystal
. flake
. granule
. pellet
. powder
. suppository
. paste
. patch
. pillShaped
. . caplet
. . capsule
. . tablet
. . . lozenge
. . . pastille
. . troche
. semiSolidEmulsion
. . cream
. solution
. . aqueous
. . . elixir
. . . syrup
. . oil
. stick
. suspension
. wafer
Device taxonomy
. spray device
. drug applicator
. drug dropper device
Process/Action taxonomy
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Douching
Rinsing
Irrigating
Spraying
Liquid installing
. Infusing
. Irrigating
Chewing
Inhaling
Ingesting
4 hierarchies of ‘form’
By Route
By Physical Form
. 'inhaled to lung form'
. . 'Inhalation Solution'
. . 'Nasal Inhalant'
. . 'Oral Inhalant'
. . 'Inhalant Powder'
. . . 'Inhalant Powder Capsule‘
. 'Solid'
. . 'Powder'
. . . 'Powder Spray'
. . . . 'Inhalant Powder'
. . . . . 'Inhalant Powder Capsule'
. . . 'Powder for Reconstitution‘
By Action
By Device
'Sustained Release Buccal Tablet'
Intermediate Representation :
MAIN tablet
HAS_PHARMACOKINETICS
sustained release
HAS_ROUTE buccal
'Sustained Release Buccal Tablet'
First parent : Form classification
Form classification:
From form taxonomy:
'Solid‘
. 'Pill‘
. . 'Tablet‘
. . . 'Sustained Release Buccal
Tablet'
pillShaped
. . caplet
. . capsule
. . tablet
. . . lozenge
. . . pastille
. . troche
'Sustained Release Buccal Tablet’
second parent : Route classification
Route classification
From route taxonomy
. 'oral mucosa form'
. . 'buccal form'
Route
. topical to conjunctiva
. topical to ear
. topical to nose
. topical to skin
. topical to scalp
. topical to oral mucosa
. . .'Sustained Release Buccal Tablet'
. . buccal
n.b. Pharmacokinetics – sustained release
is another classification concept
Where now?
• Preliminary work
• Quick classification of the leaf terms supplied
• Intermediate nodes from Prodigy work
Chris Wroe [[email protected]]
http://www.cs.man.ac.uk/mig/people/wroec/index.html