Transcript PowerPoint Presentation - Week 8: Infectious Changes

Week 8: Infectious Changes
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Stem cell theory
Interleukins
Neutrophilia
Monocytosis
Neutropenia
Leukoerythroblastic rxn
Shift to the left
MGP and CGP
Toxic changes
LAP
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Lymphocytosis
Reactive lymphocyte
Turk cell
Plasma cell
Immunoblast
IM (EBV)
Protein ELP
Eosinophilia
Basophilia
Leukocyte Development
Stem cell theory
 Proliferation
 Differentiation
 Maturation
 Leukocyte precursors
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Bacterial infection
Neutrophilia with shift to the left
 Toxic changes
 Leukoerythroblastic reaction
 Monocytosis with chronic infection (eg,
TB)
 Neutropenia with overwhelming infection
 High LAP score
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Leukocytosis
Shift to the Left
Neutrophilia
Mobilization of cells in the marginal
granulocyte pool (MGP) to circulating
granulocyte pool (CGP)
 Bone marrow activity leads to leukemoid
reaction
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Toxic Changes
Toxic granulations: 1o granules persisting to
the older stages
 Dohle bodies: RNA
 Vacuoles, not related to storage in EDTA
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Toxic Changes in Neutrophils
Viral Infection
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Lymphocytosis
 Beware of pediatric reference ranges
 Distinguish from CLL
Reactive lymphocytes (ATL, virocytes)
 Downey classes and Turk cell
 Immunoblast
 EBV associated with IM: do serology
 Broad g increase in protein ELP
Lymphocytosis and
Reactive Lymphocytes
Serum Protein
Electrophoresis
Parasitic Infection and Allergy
Eosinophilia in parasitic infection
 Eosinophilia and basophilia in allergy
 Note basophilia in CML
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