Transcript Down`s Syndrome and Infection

Down’s Syndrome and
Infection
 Known
high mortality (1960-71)
– Respiratory diseases
– Infectious diseases
– Cardiac diseases
– Malignancies
x62
x12
x6
x?
Down’s Syndrome and
Infection
 Predisposition
to Infection
– Structural
»Cardiac disease
»ENT anatomy
– Immunological
»Primary
»Secondary
Down’s Syndrome and
Infection
 Predisposition
to Infection
– Primary
»Cellular
»Humoral
– Secondary
»Diabetes
»Coeliac disease
Down’s Syndrome and
Infection
 Evidence
for immune dysfunction
 Rate of infections
 Production of antibodies after
immunisation (variable)
 Cellular function (variable)
Down’s Syndrome and
Immunisation - 1
 All
routine
 Influenza
 Pneumococcal
 ?Hepatitis B
 Special consideration when abroad
Down’s Syndrome and
Immunisation - 2
 So
many unknowns therefore
 ?multicentre trial
– usual immunisations
– pneumococcal
– influenza
– ?hepatitis B
»monitor immunological responses
»monitor infection rates