Transcript Gut Inflammation - ACIM Connect > Home

Gut-Brain Regeneration:
The microbiome as a new avenue for
therapeutic management
Zach Bush, MD
Internal Medicine, Endocrinology and Metabolism
Founder, Director of Clinical Affairs
Revolution Health Center
Scottsville, VA
Founder, CEO
Biomic Sciences
Disclosure
• I discovered carbon-based bacterial metabolites that
have the potential to function as Redox signaling
molecules
• I am founder and CEO of Biomic Sciences that has
brought to market RESTORE, the first Carbon-based
redox molecule supplement, and my team has created a
new paradigm of cell signaling science
• I am the founder and President of Revolution Health
Center
• My clinical and basic science operations and experience
that I share with you today produce all of my income
USA Ranks 49th in health outcomes
1st World Epidemics
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Autism 1:68
Attention Deficit 1:10 (70% medicated)
Asthma 1:10
Allergy 1:4
Diabetes 1:4
Obesity 1:3
Major Depression 1:2
Cancer 1:2
Dementia 1:1
1st World Epidemics
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Autism 1:68
Attention Deficit 1:10 (70% medicated)
Asthma 1:10
Allergy 1:4
Diabetes 1:4
Obesity 1:3
Major Depression 1:2
Cancer 1:2
Dementia 1:1
1st World Epidemics
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•
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Autism 1:68
Attention Deficit 1:10 (70% medicated)
Asthma 1:10
Allergy 1:4
Diabetes 1:4
Obesity 1:3
Major Depression 1:2
Cancer 1:2
Dementia 1:1
Root Cause
of Aging
and Disease
Root Cause
of disease?
Inflammation is the root of all
chronic disorder and disease
Autism
Oxidative Stress
• Acute inflammation can save our lives
– Injury Repair
– Infection control
• Chronic inflammation
– oxidative stress = positive charge/acid
– Shutdown/overwhelm of the antioxidant system
chronic inflammation = loss of communication
What is the
RootRoot
Cause
of Aging
and Disease
Cause
of Inflammation?
Ecosystem News
• Bacterial population patterns in the human gut
predict occurrence of chronic inflammatory disease
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–
Obesity/Diabetes
Asthma
Autoimmunity
Cancers
Dementia
Autism
The GALT
• Gastrointesinal Associated Lymphatic Tissue
GALT: 80% of the
antibodies in your
body are made here
Gut Inflammation
Food Sensitivity
Asthma/Eczema
Allergy
Autoimmune
Intercellular Tight Junctions
Firewalls of Defense
Gut/Brain Axis
• Gut injury: Gluten, Glyphosate,
Lipopolysaccharides
• Zonulin goes systemic
• Tight junction injury
– Gut
– Blood/brain barrier
– Vascular system
– Kidney tubules
Gut/Brain Axis
• Leaky Brain
– Interleukin inflammatory cytokines
– Neuro transmitter dysregulation
– Neuro-hormonal stress
A catastrophic vulnerability
Bacteria
Unprotected
Membranes
Tight Junction Toxins
Bacteria
Bacterial metabolites:
Carbon-based Redox system
• Each bacterial species (30,000 species) creates a unique
subset of carbon metabolites during the digestive process
Carbon Redox
• These function as an interspecies molecular
communication network that allows for coordinated cell
protection, injury response, and repair
www.restore4life.com
What are your bacteria saying?
• Dysbiosis: broken ecosystem
– Monoculture
Antibiotics, pesticides, chemicals, processed foods
• Weeds grow up: E.Coli, Klebsiela, Psudomonas, Candida
Probiotics – 3 - 24 species, $30 Billion monoculture
Monoculture = limited vocabulary = limited defense
• Optimal bowel ecology = 20,000 species
Biodiversity = fluid communication = strong defenes
Leaky Gut/Brain Leak Gut
GLYPHOSATE
BACTERIAL/YEAST
OVERGROWTH
GLUTEN
Toxic Peptides
CXCR3
Enzymes
ENZ
Chronic Inflammation
Inflammation
Leaky Gut
TJ breakdown
ZONULIN
Vagal Nerve Stimulation and
CNS inflammation
Functional Gut Barrier
www.restore4life.com
Leaky Gut in real time
CONTROL
Gluten in 1 slice of pizza
www.restore4life.com
Bacterial Communication
Frontlines of Defense
TIGHT JUNCTIONS
TEER ohms/cm2
Bacterial communication impacts
tight junction function
www.restore4life.com
CONTROL
GLUTEN and RESTORE
www.restore4life.com
RESTORE
GLUTEN
Bacterial communication induces
differential
Mitochondrial ROS Activity
ROS production
ROS assay RT- PCR
HEALTHY
DAMAGED
(MCF-7)
1
3
5
10
60
Minutes
www.restore4life.com
Bacterial communication impacts
Stem Cell Activation
Urine CD133
Urine CD133
www.restore4life.com
1st and 2nd birth of our children
HUMAN
70 Trillion Cells
25,000 Genes
Bacteria
BACTERIA
20,000 Species
1.4 Quadrillion Cells
2 Million Genes
www.restore4life.com
Epigenetics / Micro RNA
• Which genes turn on/off is determined by your
environment
• Micro RNA are non-coding sequences in the
genome that turn on and off gene pathways at
the DNA level
• 15% of the micro RNA that is circulating in your
blood stream today are from the bacteria in your
gut
– Bacterial genome is turning on and off the human
genes
www.restore4life.com
USA Ranks 49th in health outcomes
www.restore4life.com
The natural history of neurologic injury
• Children are being born into an ever more narrow bacterial
ecosystem (vulnerability)
• Breast milk and food/drink thereafter is contaminated with
glyphosate-based herbicides
• Gluten, polyunsaturated oils, and other refined foods
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(leaky gut/leaky brain occurs)
Exposure to antibiotics, NSAIDS, Alcohol, invasive bacteria,
parasites
Leaky Gut/Leaky Gut Brain – Toxins accumulate
(accelerating neurologic injury)
Widespread immune dysfunction (invasive bacteria, chronic
viremia – HPV, HSV, HepC, HIV)
Shutdown of the antioxidant system (chronic inflammation)
System overwhelm (Autism to Alzheimers, CVD to Cancer)
Leaky Gut - Leaky Brain
Inflammation cascade from birth to
death
Colic
Sensory processing defects
Attention Deficit
Anxiety Disorders
Major Depression
Disordered Sleep
Insulin resistance
Infertility
Diabetes
Vascular Disease
Cancer
Dementia
Gut/Brain Injury
What can we do about it?
Soil/Gut Communication Supplementation:
• Tight Junction firewall up and running
• Direct toxin antidote – glyphosate, gluten
• Promote eco-diversity in the gut and beyond
• Increase bacterial breakdown of toxins
• Increase bio-availabilty of food nutrients
Maximize the Biome:
Get out in nature – breathe biodiversity
Grow your own food
Eat from the bottom of the food chain
Stop Dairy (high glyphosate, highly acidic)
Fermented foods:
Miso Soup, Sauerkraut, etc
www.restore4life.com
What’s in Restore?
• Carbon-based redox molecules extracted from fossil soil
in the South West United States
• Trace micronutrients – minerals and amino acids with
concentration profiles similar to that of a sweet potato
skin
• Unprecedented results in cellular safety studies
– Gold-standard Renal Tubule Toxicity studies – No LD50, extends
life of cell lines at every concentration
– Even at 100% concentrations
Restore Logistics
• 1 tsp to 1 TBL three times daily before or with
meals
• For very sensitive kids:
– 2-5 drops by mouth – plain or
with non-chlorinated water/juice
– Slowly increase to 1 tsp three times daily
• Once on restore you can stop probiotics and
digestive enzymes to speed recovery of natural gut
biome diversity and healthy digestive processes
• No drug-drug interactions
References
1.
Centers for Disease Control and Prevention (CDC), Key Findings: Trends in the
Parent-Report of Health Care Provider-Diagnosis and Medication Treatment for
ADHD: United States, 2003-2011 the National Survey of Children's Health (NSCH)
2.
Ellwood P, Williams H, Aït-Khaled N, Björkstén B, Robertson C, ISAAC Phase III
Study Group. Translation of questions: The International Study of Asthma and
Allergies in Childhood (ISAAC) experience. Int J Tuberc Lung Dis. September 2009;
13(9): 1174-1182
3.
Massey JT, Moore TF, Parsons VL, Tadros W. Design and estimation for the
National Health Interview Survey, 1985–1994. National Center for Health Statistics.
Vital Health Stat 1989;2(110)
4.
Botman SL, Moore TF, Moriarity CL, Parsons VL. Design and estimation for the
National Health Interview Survey, 1995–2004. National Center for Health Statistics.
Vital Health Stat 2000;2(130)
5.
Centers for Disease Control and Prevention. National Diabetes Statistics Report:
Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US
Department of Health and Human Services; 2014
References
6.
Janeway, CA Jr.; et al. (2001). "The mucosal immune system". Immunobiology. New
York: Garland Science. 10-13
7.
Salminen S, Bouley C, Boutron-Ruault MC, et al. (1998). "Functional food science
and gastrointestinal physiology and function". British Journal of Nutrition 80 (S1):
S147–S171
8.
Moriame G; et al. Viral Suppression and Immune Restoration in the Gastrointestinal
Mucosa of HIV Type 1-Infected Patients Initiating Therapy during Primary or Chronic
Infection Journal of Virology, August 2006, p. 8236-8247, Vol. 80, No. 16
9.
Abbas A.B.; Lichtman A.H. (2009). "Ch.2 Innate Immunity". In Saunders (Elsevier).
Basic Immunology. Functions and disorders of the immune system (3rd ed.)
10. Eming, S. A.; Krieg, T.; Davidson, J. M. (2007). "Inflammation in wound repair:
molecular and cellular mechanisms". Journal of Investigative Dermatology 127 (3):
514–525
11. Van Dorpe, S; et al. (2012). "Brainpeps: The blood–brain barrier peptide database".
Brain structure & function 217 (3): 687–718
12. Schneider, Stefan W.; et al. (March 2004). "Glioblastoma cells release factors that
disrupt blood–brain barrier features". Acta Neuropathologica 107 (3): 272–276
References
13. H Chen; EE Konofagou. Journal of Cerebral Blood Flow &
Metabolism (2014) 34, 1197–1204
14. H Matsui ; et al. (2011). The pathophysiology of non-steroidal antiinflammatory drug (NSAID)-induced mucosal injuries in stomach
and small intestine J Clin Biochem Nutr. 2011 Mar; 48(2): 107–111
15. Eadon MT; et al. Endotoxemia alters tight junction gene and protein
expression in the kidney (2012). Am J Physiol Renal Physiol. 2012
Sep 15; 303(6): F821–F830