Transcript Slide 1

The Liver
Glc
Glc
Glc  Glc6P  glycogen G1P G6P Glc
Glycerol
Lactate
Alanine
Fatty Acids
(Diet)
Glycerol
Lactate
Alanine
Glycolysis
Krebs
Fatty Acids
OUT
VLDL
(chol, TAG)
VLDL
(chol, TAG)
IN
Fatty Acids
(adipose)
Amino
Acids
Fatty Acids
(adipose)
Amino
Acids
AcetylCoA
Glucogenic
Ala,Ser, Cys
Gly, Thr, Trp
ketone
bodies
Pyruvate
ketone
bodies
Other glucogenic AA
Arg, Gln, Glu, Pro, His to
aKG
Ketogenic
AcetyCoA Ile, Met, Val to succCoA
Ile, Leu, Thr, Trp
(Leu, Lys, Phe, TyrAcAc Asp, Phe, Tyr to fumarate
AA1 + aKG  OAA + Glu
Asp, Arg to OAA